Prevalência de alérgenos nos produtos dermatológicos brasileiros

• Ano de defesa: 2014
• Autor(a) principal: Vanessa Barreto Rocha
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Minas Gerais; UFMG
• Palavras-chave em Português: Dermatite alérgica de contato; Aditivos; Conservantes farmacêuticos; em cosméticos; Dermatite de contato; Alérgenos/classificação; Brasil; Bases de dados factuais; Aditivos em cosméticos; Medicina; Sistemas de informação; Terminologia como assunto
• Link de acesso: http://hdl.handle.net/1843/BUBD-9VZK3E

INTRODUCTION: Many preservatives and fragrances with well known sensitization potential are commonly found in vehicles of dermatological products. In Brazil a database that classifies Brazilian dermatological products through the presence of this kind of allergen does not exist. OBJECTIVES: To assess the presence and prevalence of selected vehicles in Brazilian dermatological products and to create Brazilian database that allows the classification of dermatological products in relation to the absence of these allergens, in order to make it available for physicians consultation. MATERIALS AND METHODS: From the contents of the labels and bulls, the composition of 921 Brazilian dermatological products were analized, divided into cosmeceuticals, moisturizers, soaps and cleansing lotions, shampoos, "brand" topical drugs and generic topical drugs, injectable drugs and sunscreens. For this analysis, twenty-one allergens were selected. No chemical analysis was made. RESULTS: Lists of products without the allergens were created. The most prevalent one was fragrance (61.5%), and the most common preservative was propylene glycol (37.6%), followed by phenoxyethanol (33%) and parabens (32.2%). Eighty-eight percent of products had at least one of the allergens. The average number of allergens per product was 2.89, with a standard deviation of 1.95 and a median of three. The class of products with the highest number of allergens was sunscreens. CONCLUSION: All 21 allergens were identified in dermatological products. A database has been created, called Programa para Pesquisa de Alérgenos de Contato (PPAC), available at www.ppac.com.br, where lists of dermatological products without the presence of certain allergens can be consulted. The availability of data to query the class dermatological will permit ready identification of products which these allergens are present, optimizing prescription and avoiding potential damage to patients that are allergic to dermatological vehicles.