Análise da influência do nível de atividade física com o polimorfismo do gene FTO, e a relação com a modulação autonômica cardíaca em estudantes de uma escola pública de São Luís do MA.

• Ano de defesa: 2023
• Autor(a) principal: RABÊLO, Luís Gustavo Dias
• Orientador(a): MOSTARDA, Cristiano Teixeira
• Banca de defesa: MOSTARDA, Cristiano Teixeira , DIAS FILHO, Carlos Alberto Alves , PIRES, Flávio de Oliveira , SOARES JUNIOR, Nivaldo de Jesus Silva
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal do Maranhão
• Programa de Pós-Graduação: PROGRAMA DE PÓS-GRADUACAO EM EDUCAÇÃO FÍSICA
• Departamento: DEPARTAMENTO DE EDUCAÇÃO FÍSICA/CCBS
• País: Brasil
• Palavras-chave em Português: Polimorfismo do gene FTO; Variabilidade da frequência cardíaca; Nível de atividade física
• Palavras-chave em Inglês: FTO gene polymorphism; Heart rate variability; Level of physical activity
• Área do conhecimento CNPq: Fisiologia Comparada
• Link de acesso: https://tedebc.ufma.br/jspui/handle/tede/4904

Objective: To analyze the influence of physical activity level with FTO gene polymorphism, and its relationship with cardiac autonomic modulation in students from a public school in São Luís, MA. Materials and methods: A descriptive, quantitative, and cross-sectional field research was conducted with 288 students of both sexes, aged between 11 and 18 years old, enrolled in the public school system in the city of São Luís, MA. They were divided into four groups (AA+AT act, AA+AT sed, TT act, and TT sed), taking into account the genotypes AA, AT, and TT. Physical activity level, body mass index, anthropometric measurements, oral cell collection, DNA extraction, and PCR to identify the FTO gene polymorphism, blood pressure recording, and heart rate variability recording were evaluated. Data were analyzed using the JAMOVI program. The statistical treatment consisted of the Shapiro-Wilk Normality test, one-way ANOVA with Tukey's post-hoc test. Data were considered statistically significant when the pvalue was less than <0.05, at a 95% confidence interval. In addition, the ChiSquare test was used to analyze allelic distribution. Results: There were no significant differences between groups for SBP, DBP, and HR variables. For weight, TT sed individuals compared to TT act group (53.50 ± 9.61) showed a statistically significant difference and a higher mean value than all other groups. Regarding BMI, there were no significant differences in any group. CC showed significantly higher results for TT sed group compared to TT act (68.19 ± 6.89). For NAF, sedentary individuals, both AA+AT and TT (370.16 ± 169.78) and (341.87 ± 152.79) obtained significant differences compared to active groups, demonstrating a lower level of physical activity (p<0.001). Regarding heart rate variability, the results showed no statistically significant differences between groups for time-domain variables [RR(ms), RMSSD(ms), SDNN(ms), PNN50(ms)] and frequency-domain variables [BF(ms2), AF(ms2), BF (%), AF(%) and BF/AF]. Conclusion: The research demonstrated that the physical activity level in students who have the FTO gene polymorphism does not affect cardiac autonomic modulation.