ANESTESIA COM CETAMINA S(+) ASSOCIADA À ATROPINA E XILAZINA EM CÃES: AVALIAÇÃO CARDÍACA E BIOQUÍMICA SÉRICA

• Ano de defesa: 2008
• Autor(a) principal: FRANCO, Leandro Guimarães
• Orientador(a): SILVA, Luiz Antônio Franco da
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Goiás
• Programa de Pós-Graduação: Mestrado em Ciência Animal
• Departamento: Ciências Agrárias - Veterinaria
• País: BR
• Palavras-chave em Português: creatinoquinase-MB, ecocardiograma, isquemia, miocárdio, quetamina
• Palavras-chave em Inglês: creatine kinase MB, echocardiogram, ischemia, ketamine, myocardium
• Área do conhecimento CNPq: CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA::PATOLOGIA ANIMAL::PATOLOGIA CLINICA ANIMAL
• Link de acesso: http://repositorio.bc.ufg.br/tede/handle/tde/895

Changes in physiological parameters of electrocardiography, echocardiography and biochemistry markers were evaluated in dogs anesthetized with different associations of atropine, xylazine and S-ketamine. Twenty three healthy female dogs randomly distributed in four groups named as GI-6, GII-6, GIII-6 and GIV-5 were treated respectively with atropine and S-ketamine (0,04mg/kg; 10 mg/kg); S-ketamine (10 mg/kg); atropine, xylazine and S-ketamine (0,04mg/kg; 1,1 mg/kg; 10 mg/kg) and xylazine and S-ketamine (1,1 mg/kg; 10 mg/kg). Ten minutes after induction, 5mg/kg of S-ketamine was administered to animals from all groups. Measurements of electrocardiogram, echocardiogram and serum activity of aspartate aminotransferase (AST), creatine kinase (CK) and creatine kinase MB isoenzyme (CK-MB) were evaluated for 36 hours. Concerned to electrocardiography, the proposed anesthetic protocols showed significant changes especially in atrioventricular conduction period (PR interval) and systole period (QT interval), mostly in GIV. In relation to echocardiography, the main alterations happened in following variables, final stroke volume, ejection fraction and cardiac output, predominantly in GIV. In serum biochemistry analysis, it was observed alterations in CK and CK-MB values in all groups, which maintained changed for a longer time in GIII and GIV. Thus, under conditions of this study, it can be conclude that atropine, xylazine and S-ketamine association (GIII) determined lower effects on heart, while marking alterations occurred in animals from GIV