Detalhes bibliográficos
| Ano de defesa: |
2020 |
| Autor(a) principal: |
Alves, Ana Gabriella Pereira
 |
| Orientador(a): |
Silva, Maria Sebastiana
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| Banca de defesa: |
Silva, Maria Sebastiana,
Hadler, Maria Claret Costa Monteiro,
Guillo, Lídia Andreu,
Santos, Renata Carvalho dos,
Martins, Karine Anusca |
| Tipo de documento: |
Tese
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| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
Universidade Federal de Goiás
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| Programa de Pós-Graduação: |
Programa de Pós-graduação em Ciências da Saúde (FM)
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| Departamento: |
Faculdade de Medicina - FM (RMG)
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| País: |
Brasil
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| Palavras-chave em Português: |
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| Palavras-chave em Inglês: |
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| Área do conhecimento CNPq: |
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| Link de acesso: |
http://repositorio.bc.ufg.br/tede/handle/tede/12640
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Resumo: |
Introduction: Vitamin D plays a role in several metabolic pathways, including cell diferentiation and proliferation, hormonal control, modulation of inflammation and immune system regulation. Since vitamin D receptors are presented in different tissues and organs, it is related to many diseases, such as obesity, hipertension and dyslipidemia. Objective: To evaluate the serum levels and the effect of cholecalciferol supplementation on body composition and metabolic profile in of children. Methods: A randomized, placebo-controlled, triple-blind, crossover study was conducted with 62 children, 4 to 11 years old, from a public educational institution, that met the selection criteria. Sociodemographic, economic and sunscreen use data were collected from a specific questionnaire; the body area daily exposed to the sun was evaluated by a questionnaire with a representative figure of the body percentage; a specific questionnaire was used to evaluate physical activity and sedentary behavior; anthropometry (body mass and height) and body composition (waist circumference, body fat percentage, fat-free mass, triceps and subscapular skinfolds) were obtained using a stadiometer, electronic scale, anthropometric tape, tetrapolar bioimpedance and adipometer; blood pressure was measured using an automatic digital monitor; 25-hydroxyvitamin D [25(OH)D], fasting glucose and lipid profile were analysed from blood collection; and food intake data was evaluated through the 24-hour recall. In the intervention study, the two groups, supplemented and placebo, received 5 drops of cholecalciferol (1000 IU/day) and 5 drops of sunflower oil (placebo), respectively, for 12 weeks, separated by 10-week washout period. Results: Among children with sufficient serum vitamin D (≥ 75 nmol/L), who participated in the baseline study, no difference was found in sex, self-reported race, physical activity, age, anthropometry, body composition, biochemical parameters and blood pressure between children with 25(OH)D 75-99 and ≥ 100 nmol/L, in addition to the non-association of 25(OH)D with body composition and metabolic profile. In the crossover study, conducted with hypertriglyceridemic children, cholecalciferol supplementation reduced serum total cholesterol (TC) (p < 0.001), LDL-c (p < 0.001), non HDL-c (p < 0.001), TC/HDL-c (p = 0.001) and LDL-c/HDL-c (p < 0.001) ratio, when compared to placebo group. Conclusions: Serum vitamin D was not associated with body composition and metabolic profile among children with 25(OH) ≥ 75 nmol/L, and 1000 IU/day of cholecalciferol supplementation, for 90 days, in hypertriglyceridemic children without 25(OH)D serum deficiency, was able to improve lipid profile. |
