Detalhes bibliográficos
| Ano de defesa: |
2014 |
| Autor(a) principal: |
Naves, Letícia Nasser
 |
| Orientador(a): |
Marreto, Ricardo Neves
|
| Banca de defesa: |
Marreto, Ricardo Neves,
Martins, Rodrigo Molina,
Diniz, Danielle Guimarães Almeida |
| Tipo de documento: |
Dissertação
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| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
Universidade Federal de Goiás
|
| Programa de Pós-Graduação: |
Programa de Pós-graduação em Ciências Farmacêuticas (FF)
|
| Departamento: |
Faculdade Farmácia - FF (RG)
|
| País: |
Brasil
|
| Palavras-chave em Português: |
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| Palavras-chave em Inglês: |
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| Área do conhecimento CNPq: |
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| Link de acesso: |
http://repositorio.bc.ufg.br/tede/handle/tede/5571
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Resumo: |
Inflammatory bowel diseases are chronic conditions that affect different portions of the gastrointestinal tract. The treatment of these conditions aims to induce and maintain the remission of the symptoms, controlling recurrences. The clinical efficacy of the treatment can be enhanced using colon-specific drug release systems, since they allow topical treatment, lower systemic drug absorption and therefore increase the safety of therapy. The use of time-dependent polymers, such as ethylcellulose, and/or polymers that can be degraded by colonic bacteria, such as pectin, are both strategies used to develop colonic drug delivery systems. The association of these strategies has been performed in order to further increase the efficiency of the systems. Thus, the aim of the present work was develop pellets and matricial tablets containing different amounts of ethylcellulose and pectin for colon-specific release of prednisone. Pellets were obtained by extrusion-spheronization method and were evaluated for wet mass processability, sphericity, size distribution, flowability and drug content. Hydroethanolic mixtures and alcoholic or aqueous dispersions (Surelease®) of ethylcellulose were tested as granulation liquid. The release profiles of prednisone from pellets were determined using the apparatus III of the United States Pharmacopoeia, simulating the path of the dosage form through the gastrointestinal tract. The drug release from the pellets seems to be dependent on the ethylcellulose dispersion in the matrix, which was defined by the production method used. The addition of ethylcellulose in ethanol gave rise to a prednisone sustained release profile, whereas its incorporation as a dry powder resulted in rapid drug release. The use of ethylcellulose aqueous dispersion (Surelease®) resulted in an intermediate release performance. Furthermore, the amount of granulation liquid and its ethanol concentration have affected the shape of the pellets. Lower ethanol concentration (24%) impaired the spheronization of extrudates. Granulation liquid prepared with 40% ethanol enabled the formation of spherical pellets, but with reduced mechanical stability. The appropriate amount of solution prepared with 35% ethanol resulted in formulations with spherical shape and adequate mechanical strength. The sphericity of the pellets affected their flowability. In addition, tablets containing pectin and ethylcellulose were prepared by wet granulation or direct compression. The average weight, content uniformity and in vitro release from the tablets were evaluated. The tablets obtained by direct compression have provided better control release compared to those prepared by wet granulation. The reduction of particle size of the ethylcellulose in the tablets prepared by direct compression was critical to increasing the efficiency of the system. Thus, tablets prepared with ethylcellulose finer fraction (diameter <180μm), containing 20% pectin showed the highest efficiency of colon-specific drug release. These systems may represent a simple option for the control of inflammatory bowel disease. |
