Detalhes bibliográficos
| Ano de defesa: |
2017 |
| Autor(a) principal: |
Gomes, Filipe Augusto Sales
 |
| Orientador(a): |
Martins, Danieli Brolo
|
| Banca de defesa: |
Martins, Danieli Brolo,
Paes, Paulo Ricardo de Oliveira,
Souza, Luiz Augusto de,
Vulcani, Valcinir Aloisio Scalla,
Araújo, Eugênio Gonçalves de |
| Tipo de documento: |
Tese
|
| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
Universidade Federal de Goiás
|
| Programa de Pós-Graduação: |
Programa de Pós-graduação em Ciência Animal (EVZ)
|
| Departamento: |
Escola de Veterinária e Zootecnia - EVZ (RG)
|
| País: |
Brasil
|
| Palavras-chave em Português: |
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| Palavras-chave em Inglês: |
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| Área do conhecimento CNPq: |
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| Link de acesso: |
http://repositorio.bc.ufg.br/tede/handle/tede/7951
|
Resumo: |
Chitosan based materials are a class in development because they possess excellent characteristics for use in the biomedical sciences. Regarding chitosan suture, few studies have been performed and no studies have evaluated its response to systemic inflammation and mechanical resistance. Therefore, the aim of this thesis is to analyze the possible systemic inflammatory reactions in adult rats subjected to laparorrhaphy with chitosan suture by means of the electrophoretic analysis of polyacrylamide gel (SDS-PAGE) and its relation with the hematological findings and biochemical. In addition, investigate the mechanical resistance of the abdominal wall, the probable local inflammatory changes and the formation of collagen, through the tensiometric and histopathological analyzes. To that end, 54 adult rats (Rattus norvegicus) were divided into three groups, basel group (without surgery), chitosan and polydioxanone (gold standard), evaluated at three, seven, 14 and 21 days after laparorrhaphy. The result was that the chitosan and polydiaxonone wires have similar behaviors in the systemic and local inflammatory response, although the polydioxanone thread has a more intense response. In the evaluation of resistance, they also presented similar results, and with polydioxanone, resistance was better on the twenty-first day, with the conclusion that chitosan suture, despite the small number of researches, is a promising thread. With this, perspectives are opened for the use of chitosan suture in surgeries in veterinary medicine. However, as this is a new product, other studies should be carried out, even in different areas, as well as in other species / tissues and at different evaluation periods. |
