Proteínas de fase aguda em cães com diferentes escores corporais

• Ano de defesa: 2013
• Autor(a) principal: Carneiro, Letícia Furtado Rodrigues
• Orientador(a): Fioravanti, Maria Clorinda Soares
• Banca de defesa: Fioravanti, Maria Clorinda Soares, Brunetto, Marcio Antonio, Duque, Celina Tie Nishmori
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Goiás
• Programa de Pós-Graduação: Programa de Pós-graduação em Ciência Animal (EVZ)
• Departamento: Escola de Veterinária e Zootecnia - EVZ (RG)
• País: Brasil
• Palavras-chave em Português: Avaliação nutricional; Eletroforese; Fibrinogênio; Imunoturbidimetria; Obesidade
• Palavras-chave em Inglês: Nutritional assessment; Electrophoresis; Fibrinogen; Immunoturbidimetric; Obesity
• Área do conhecimento CNPq: CIENCIAS AGRARIAS::MEDICINA VETERINARIA
• Link de acesso: http://repositorio.bc.ufg.br/tede/handle/tede/3659

Acute phase proteins contribute to homeostasis, limit bacterial growth and, more recently, have been used as biochemical markers of nutritional status. This study aimed to determine the concentrations of acute phase proteins in dogs with different body condition scores (BCS). We used a 1-9 scale to determine the body condition score, established by inspection and palpation. We evaluated 60 dogs of different breeds and ages, being 20 lean animals (10 males and 10 females – BCS 3), 20 with ideal body score (10 males and 10 females – BCS 4 to 6), and 20 obese animals (10 males and 10 females - BCS 7 to 9). The animals fasted for 12 hours before blood sample collection for laboratory evaluation. We measured CBC, fibrinogen quantification, glucose, total protein, albumin, globulin, urea, cholesterol, triglycerides, iron, iron binding capacity (IBC), transferrin saturation index (STI), transferrin, ferritin determination, and serum protein electrophoretic fractionation on agarose gel. Leukocytes, fibrinogen, glucose, total protein, globulin, cholesterol, triglycerides, iron, IST, transferrin, alpha-1, alpha-2, beta-2 and gamma globulin showed significant difference among groups (p < 0.05). Regarding acute phase proteins, we concluded that obesity in dogs determines an increase in fibrinogen and alpha-2, beta-2 and gamma globulin fractions, indicating chronic inflammation. Higher values of leukocytes, total protein, globulin, iron, IST, glucose, cholesterol and triglycerides are expected in hematological and metabolic profile in obese dogs.