Expressão de proteínas de adesão (e-caderina e β - catenina) e proliferação celular (ki-67) no fronte de invasão tumoral de Carcinomas Espinocelular e Escamoso Basalóide

• Ano de defesa: 2014
• Autor(a) principal: Pereira, Carlos Henrique
• Orientador(a): Mendonça, Elismauro Francisco de
• Banca de defesa: Mendonça, Elismauro Francisco de, Batista, Aline Carvalho, Oton-Leite, Angélica Ferreira
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Goiás
• Programa de Pós-Graduação: Programa de Pós-graduação em Odontologia (FO)
• Departamento: Faculdade de Odontologia - FO (RG)
• País: Brasil
• Palavras-chave em Português: Carcinoma Espinocelular; Carcinoma Escamoso Basalóide; Proteína Ki-67; E-Caderina; β–catenina
• Palavras-chave em Inglês: Squamous Cell Carcinoma; Basaloid Squamous Cell Carcinoma; Ki-67 protein; E-cadherin; β-catenin
• Área do conhecimento CNPq: CIENCIAS DA SAUDE::ODONTOLOGIA
• Link de acesso: http://repositorio.bc.ufg.br/tede/handle/tede/5158

Objective: Investigate, on a comparative basis, the expression of the adhesion molecules E-cadherin (E-cad), β-catenin (β-cat) and the proliferation index (Ki-67) at the invasive tumor front (ITF) in Squamous Cell Carcinoma (SCC) and basaloid squamous cell carcinoma (BSCC). Material and Methods: Thirty-five SCC and 16 BSCC cases were evaluated by immunohistochemistry. Clinico-pathological data and survival data were evaluated and compared. Results: There was a low expression of E-cad in the cytoplasmic membrane (p = 0.50) as well as in the nucleus (p = 0.31) for both SCC and BSCC. A high expression of E-cad was seen in the cytoplasm for the SCC group (80%) when compared to the BSCC group (25%) (p<0.01). The expression of β-cat in the cytoplasmic membrane (p = 0.28) and in the cytoplasm (p = 0.44) was low in both SCC and BSCC groups. Both types of carcinoma presented low expressions of β-cat in the nucleus (p = 0.03). The Ki-67 expression was low irrespective of tumor variant. The high expression of E-cad in the cytoplasm was associated with T3/T4 tumors (p = 0.04) in the SCC group and there was no significant association of E-cad, β-cat, Ki-67 with the other clinical variables. In terms of disease-free survival and overall survival, there were no significant differences between SCC and BSCC. Conclusion: The E-cad-β-cat system was found to be dysregulated in both oral SCC and oral BSCC. The Ki-67 cell proliferation index was extremely low in the cases investigated and consequently had no prognostic value.