ESTUDO DO POTENCIAL MUTAGÊNICO E ANTIMUTAGÊNICO DA Solanum paniculatum L. PELO TESTE DO MICRONÚCLEO EM CAMUNDONGOS

Detalhes bibliográficos
Ano de defesa: 2008
Autor(a) principal: VIEIRA, Pabline Marinho lattes
Orientador(a): CHEN, Lee Chen lattes
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal de Goiás
Programa de Pós-Graduação: Mestrado em Biologia
Departamento: Ciências Biolóicas
País: BR
Palavras-chave em Português:
Palavras-chave em Inglês:
Área do conhecimento CNPq:
Link de acesso: http://repositorio.bc.ufg.br/tede/handle/tde/1278
Resumo: Solanum paniculatum L., popularly known as jurubeba, is a widespread plant species used in Brazilian folk medicine as a tonic, antifever agent, colagogue, bitter, and eupeptic to treat liver and gastric dysfunctions. The chemical composition of Solanum paniculatum has long been studied and many substances have been isolated from the entire plant, including alkaloids, resins, glucids and saponins. The aim of this study was to evaluate the mutagenic, antimutagenic and cytotoxic effects of jurubeba s ethanolic leaf and fruits extracts using micronucleus test in mice bone marrow. The experimental procedure was performed according Schimid (1975). Swiss mice were orally treated with three different concentrations (100, 200 or 300 mg/kg) of leaf or fruit extracts of S. paniculatum. To evaluate the antimutagenic activity were used the same doses of the extract simultaneously with a single dose of Mitomicin C (4mg/kg) i.p. Cytotoxicity was evaluated by the polychromatic and normochromatic erythrocytes ratio. Our results have indicated that the ethanolic leaf extract of S. paniculatum did not exhibit mutagenic effect in mice, but it showed antimutagenic effects in this extract towards MMC. The cytotoxicity was strongly demonstrated specially for higher doses. Meanwhile, the ethanolic fruit extract of S. paniculatum was mutagenic only in dose of 200 mg/Kg at time of 48 hours. It was showed the cytotoxic activity for higher doses. However, no antimutagenic effect was evidenced by fruit extract.