Detalhes bibliográficos
| Ano de defesa: |
2014 |
| Autor(a) principal: |
Ribeiro, Andrea Alves
 |
| Orientador(a): |
Santos, Silvia Helena Rabelo dos
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| Banca de defesa: |
Santos, Silvia Helena Rabelo dos,
Fiaccadori, Fabíola Souza,
Val, Izabel Cristina Chulvis do,
Alves, Rosane Ribeiro Figueiredo,
Derchain, Sophie Françoise Mauricette |
| Tipo de documento: |
Tese
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| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
Universidade Federal de Goiás
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| Programa de Pós-Graduação: |
Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP)
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| Departamento: |
Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
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| País: |
Brasil
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| Palavras-chave em Português: |
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| Palavras-chave em Inglês: |
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| Área do conhecimento CNPq: |
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| Link de acesso: |
http://repositorio.bc.ufg.br/tede/handle/tede/6827
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Resumo: |
Sexually transmitted infections are considered (STIs) pose a major public health problem. Adolescents and young adults are more likely to get Human papillomavirus (HPV) infection for two main reasons: sexual behavior and biological vulnerability. Some risk factors such as parity and number of children as well as Chlamydia trachomatis (CT) infection are co-factors associated with HPV infection responsible for precursor lesions and cervical cancer. OBJETIVE: Estimate the prevalence of HPV types and CT in adolescents and young adult females and to relate to the detection of cytological abnormalities, with sociodemographic and habits related to sexual risk factors. MATERIALS AND METHODS: This cross-sectional study included 276 adolescents and young adult females sexually active aged 15-24 years. Conventional cytology was performed to detect HPV DNA by PCR using the primers PGMY09/PGMY11 and genotyping by reverse dot blot hybridization. Detection of CT was performed by PCR using primers directed to the region encoding the cryptic plasmid. The population was stratified into two age groups: Group I (15-19 years) and Group II (20-24 years). It was conducted univariate analysis considering a p <0.20 for inclusion in the multivariate analysis to calculate the odds ratio (OR), confidence interval of 95% and significance level of <0.05. RESULTS: The prevalence of HPV infection was 47.1% (CI 95% 41.0–53.2). The HPV 16 was the most prevalent, present in 27.7% (36/129) of cases, followed by HPV 68 (8.5%; 11/130), HPV 52 (6.2 %; 8/130) e HPV 39 (4.6%; 6/130). The prevalence of HPV in the cytologic diagnosis of ASC-US was 66.7% in adolescents and 77.8% in young adult females. In diagnosis of LSIL HPV infection that present in 87.5% of adolescents and 75% of young adults females. The cytologic diagnosis of HSIL were detected only in adolescents with 100% prevalence of HPV infection. The total prevalence of CT infection was 9.1% (IC 95% 5.61–12.4). Among adolescents, the prevalence was 68% (17/25) and among young adults was 32% (8/25). The association with HPV infection related to behavioral and sociodemographic risk factors was statistically significant in the single marital status and had more than four sexual partners. Cytological abnormalities present among adolescents and young adults were associated with HPV and CT infection. CONCLUSION: HPV and CT infections are prevalent in adolescents and young adults, especially those with cytologic abnormalities. Sexual habits have a relationship with HPV infection, corroborating two of the risk factors for single marital status, the number of sexual partners. CT infection increases the risk for acquisition of cytologic abnormalities. |
