Variação da espessura retiniana por meio da tomografia de coerência óptica após aplicação de triancinolona sub-tenoniana e terapia fotodinâmica na degeneração macular relacionada a idade

• Ano de defesa: 2006
• Autor(a) principal: Japiassú, Ricardo Miguel
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Programa de Pós-graduação em Ciências Médicas; Ciências Médicas
• Palavras-chave em Português: Degeneração macular relacionada a idade; Terapia fotodinâmica; Triancinolona; MEDICINA; CIÊNCIAS MÉDICAS; Neovascularização retiniana; Tomografia de coerência óptica; Fotoquimioterapia; Age-related macular degeneration; Photodynamic therapy; Triamcinolone; OCT; Choroidal neovascularization; CNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA
• Link de acesso: https://app.uff.br/riuff/handle/1/18454

PURPOSE: Evaluate retinal thickness variation, measured by OCT, on four distinct moments, after combined PDT and PSTA, in exudative age-related macular degeneration patients, and compare these results to the same variation on four moments in patients treated by PDT as monotherapy, already described in literature. METHODS: This study was a prospective, noncomparative case series. Combined treatment with PSTA and PDT was performed on thirty-four eyes of thirty consecutive patients who presented with subfoveal CNV due to age-related macular degeneration, and serial evaluation with OCT was performed two days before PDT, when PSTA was made, immediately one hour after PDT, and then at 1 week and 1 month. RESULTS: A significant variation in retinal thickness was seen through time (p=0,0001). An increase in retinal thickness was seen from moment 1 to moment 2; a significant decrease from moment 2 to moments 3 and 4 was seen too. When we compare these results, we observe that the 4 moments graphic of PDT as a monotherapy show a thicker retinal-subretinal complex in moment 2, and a minor decrease of the graphic curve until moment 4. CONCLUSION: There was significant variation in retinal thickness, measured by OCT, in four distinct moments, after combined PSTA and PDT in exudative agerelated macular degeneration patients, mostly between moment 1 (before PDT) and moment 2 (1 hour after PDT), and between moments 2 and 3, and 2 and 4 (1 week and 1 month after treatment, respectively). When we compare these results with serial OCT analysis in four moments, performed in patients with exudative age-related macular degeneration, treated by PDT as a monotherapy, already discussed in previous literature, we can see a minor peak on moment 2 and smaller values on moments 3 and 4. This fact suggests that retinal thickness variation values can be closer to a physiological curve when we perform combined PSTA and PDT, when compared to PDT as a monotherapy.