Influência da exposição aguda à fumaça de cigarro sobre parâmetros bioquímicos gasométricos e desempenho físico em ratos

• Ano de defesa: 2014
• Autor(a) principal: Souza, Gisela Vicentini de
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal do Espírito Santo; BR; Mestrado em Educação Física; Centro de Educação Física e Desportos; UFES; Programa de Pós-Graduação em Educação Física
• Palavras-chave em Português: Smoking; Performance Evaluation; Blood Gas Analysis; Hypoxia; Tabagismo; Avaliação de Desempenho; Gasometria; Hipóxia; Fumo - Vício; Aptidão física - Avaliação; Educação Física; 796
• Link de acesso: http://repositorio.ufes.br/handle/10/7258

Introduction. The smoke causes the development of diseases, promotes increased risk of cardiovascular diseases and can cause even sudden death. Smokers are exposed to high carbon monoxide concentrations present in cigarette smoke, promoting the reduction in oxygen in muscle tissues with the potential to cause loss of aerobic capacity and hypoxia. Objective. To investigate the time course of blood gas biochemical changes and assess whether the biochemical changes induced by EFC are associated with physical performance of rats submitted to physical test of swimming. Methodology. Male Wistar rats were divided into two groups: control (C, n=8) and acutely exposed to cigarette smoke (EFC), divided in three groups Mo 1 (0-30min post EFC, n=11), Mo 2 (30 -60min post EFC, n=14) and Mo 3 (60-120min post EFC, n=10), for eight consecutive days. All animals were weighed before and after the trial period, and subjected to performance evaluation for swimming physical test and hemogasometric analysis of arterial, blood samples were obtained by catheterization of the carotid artery. Results. Found reduction in body weight of the animals EFC compared to control animals (C=524.6± 12,1g; Mo 1=463.3±10,9g; Mo 2=482.8±9.2g; Mo 3=499.3±9,8g). The values of hemogasometric analysis is presented with a significant increase for the concentration of carboxyhemoglobin (C=0.0±0.0%; Mo 1=25.4±0.6%; Mo 2=13.6±0.5%; Mo 3=8.2± 0.7%), with statistical difference between groups (p=0.001); For Methemoglobin (C=0.1±0.1%; Mo 1=1.9±0.3%; Mo 2=0.4±0.1%; Mo 3=0.3±0.1%) was no statistical difference between Mo 1 group compared to the C group (p=0.001); The Oxygen Saturation (C=78.2 ± 1.5%; Mo 1=91.4±2.0%; Mo 2=87.1±1.8%; Mo 3=84.5±2.9%) had statistical difference between Mo 1 and Mo 2 groups compared to C group (p=0.003); For deoxy-hemoglobin (C=21.90±1.5%; Mo 1=6.33±1.5%; Mo 2=11.31±1.5% and Mo 3=15.25±2.4%) was reduced significant among Mo 1 and Mo 2 groups compared to C group (p=0.001); For Lactate (C=1.71±0,2mmol/L; Mo 1=2.62±0,2mmol/L; Mo 2=1.79±0,1mmol/L; Mo 3=1.54±0,0mmol/L), a significant increase between Mo 1 group compared with C group (p=0.012). For the evaluation of performance in physical exhaustion test in swimming, there was no statistical difference in the animals time EFC compared to control animals (C=373.0±39,8s; Mo 1=273.0±15,9s; Mo 2=298.5±23,0s; Mo 3=318.4±24,2s). We note the significant association EFC animals (p=0.001, r-0.886) between higher value carboxyhemoglobin with shorter blood collection. Conclusion. Acute exposure to cigarette smoke causes changes in blood gas and biochemical parameters affect the transport of oxygen. In the model acute exposure to cigarette smoke used in this work, we found impairment in physical performance in EFC rats subjected to physical exhaustion test in swimming.