Desenvolvimento uterino em cadelas do nascimento aos seis meses de idade:análise histomorfométrica

• Ano de defesa: 2012
• Autor(a) principal: Ramos, José Leonardo Gualberto
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal do Espírito Santo; BR; Mestrado em Ciências Veterinárias; Centro de Ciências Agrárias e Engenharias; UFES; Programa de Pós-Graduação em Ciências Veterinárias
• Palavras-chave em Português: Endometrial glands; Uterus; Development; Histology; Bitch; Glândulas endometriais; Útero; Desenvolvimento; Histologia; Cadela; Ginecologia veterinária; Endométrio; Glândulas; Histologia veterinária; Medicina Veterinária
• Link de acesso: http://repositorio.ufes.br/handle/10/5852

The development of research aimed at better understanding the formation and functioning of the female reproductive system as a basis for development of contraceptive methods has become increasingly relevant. Furthermore, characterization of uterine development, mainly endometrial glands in dogs has not yet the description as observed in other species. The objective of this study was to evaluate the chronology of the uterine development in prepubertal bitches (endometrium, myometrium and perimetrium) with emphasis on the development of endometrial glands. We evaluated uteri of 32 bitches with a prepubertal and 180 days postnatal (DPN). These animals were divided into eight groups of four animals each: G1 = 1DPN, G2 = 15DPN, G3 = 30DPN, 45DPN = G4, G5 = 60DPN, 90DPN = G6, G7 and G8 = 120DPN = 180DPN. We evaluated the type of epithelium, the presence of endometrial glands and quantity, the measurement of the total thickness of the uterine wall (mM), thickness of the myometrium (mM), endometrial thickness (mM), diameter (mm) and number (n°/mm2) of endometrial glands. The histoarchitecture uterus with 1 DPN revealed rudimentary feature supported with simple cubic cells in the stroma in organization, with lamina propria devoid of glands, with 15 DPN observed presence of rudimentary structures, starting from invaginations (endometrial folding) from 30 to 45 days was observed discrete branching glands that became more evident; DPN at 60 and from this period, there was an increase of glandular development in an ongoing process until the last period evaluated (180 DPN). All structures evaluated had low coefficient of variation (<10%) demonstrating homogeneity of data evaluated, as well as significant correlations (P <0.0001) between all variables with age animal [total uterine wall (R2 = 97, 4%), endometrial total (R2 = 99.4%), total myometrium (R2 = 95.8%), number of endometrial glands (R2 = 92.3%); diameters of endometrial glands (R2 = 94.1% ) and epithelial height (R2 = 72.2%). We conclude that the uterus of bitches is devoid of endometrial glands at birth and they begin continuous development from birth to 15 days and 60 days after birth are already fully formed