Doença pulmonar por micobactérias não-tuberculosas : vinte e cinco anos de experiência no Espírito Santo, Brasil

• Ano de defesa: 2024
• Autor(a) principal: Miossi, Rubia
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal do Espírito Santo; BR; Mestrado em Doenças Infecciosas; Centro de Ciências da Saúde; UFES; Programa de Pós-Graduação em Doenças Infecciosas
• Palavras-chave em Português: Micobactérias não Tuberculosas (MNT); Doença Pulmonar; Epidemiologia; Desfecho de Tratamento; Toxicidade; Mycobacterium kansasii; Mycobacterium abscessus; Doenças Infecciosas e Parasitárias
• Link de acesso: http://repositorio.ufes.br/handle/10/18245

Diseases caused by Non-Tuberculous Mycobacteria (NTM) are on the rise. This retrospective and observational study analyzed 111 cases of NTM Pulmonary Disease treated at HUCAM-UFES between June 1998 and September 2023. The study revealed a significant increase in cases from 2017 onwards, with 50% of cases occurring after this period. The average age of patients was 60 years, with no gender predominance, and most had comorbidities (70.3%). Productive cough and weight loss were common symptoms, with a prolonged disease course prior to diagnosis. Chest radiographs showed patterns like tuberculosis. The most frequent species were M. abscessus (33.3%), M. kansasii (30.6%), and M. intracellulare (15.3%). The species M. kansasii were more frequent in urbanized areas. The M. abscessus group had the highest treatment failure rate (40.5%) and the most significant toxicity (56.8%). Future studies should focus on treatment and toxicity to further understand these emerging infections