Tratamento precoce com o trans-4-metoxi-beta-nitroestireno previne o desenvolvimento da hipertensão arterial pulmonar induzida por monocrotalina em ratos

Detalhes bibliográficos
Ano de defesa: 2020
Autor(a) principal: Silva, Jussara Matyelle Rodrigues da
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Não Informado pela instituição
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Link de acesso: http://www.repositorio.ufc.br/handle/riufc/56804
Resumo: Pulmonary arterial hypertension (PAH) is a severe and progressive disease of the small pulmonary arteries. In this context, the aim of this study was to study the preventive effect of trans-4-methoxy-beta-nitrostyrene (T4MN), a substance that stimulates the nitric oxide / guanylate cyclase soluble / cyclic guanosine monophosphate pathway (NO / sGC/ GMPc), in the experimental model of PAH in rats. For that, Wistar rats were used that received subcutaneous injection of 60 mg / kg of monocrotaline (MCT) on day zero (D0). After 1h, treatment by gavage route with T4MN at doses of 18.75 and 37.5 mg/kg and mg / kg was started. After the treatment period for 28 consecutive days, the experiments were carried out. Treatment with T4MN was unable to improve some rates of cardiac hypertrophy. However, treatment with this nitroderivative caused a significant improvement of pulmonary hypertrophy. The results from hemodynamic studies showed that T4MN significantly reduces right ventricular systolic pressure (RVSP) in PAH and improves endothelium-dependent vascular relaxation, in addition to reducing the vasoconstrictor effect induced by phenylephrine, an alpha1-adrenergic agent. Therefore, in the experimental conditions of the present study, T4MN exhibited potential activity in the early treatment of pulmonary arterial hypertension.