Perfil anatomopatológico dos carcinomas ductais em um serviço de referência de Fortaleza de 2005 : correlação com a idade e com as metástases axilaresa 2014

• Ano de defesa: 2016
• Autor(a) principal: Aquino, Ranniere Gurgel Furtado de
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Palavras-chave em Português: Neoplasias da Mama; Gradação de Tumores; Carcinoma Ductal de Mama; Distribuição por Idade
• Link de acesso: http://www.repositorio.ufc.br/handle/riufc/24116

Breast cancer is the most common cancer in women worldwide, and its morphological characteristics, despite the current molecular classification, also provide important information about the pattern of this disease. In order to standardize the morphological classification of breast cancer and to refine the clinical applicability of anatomopathological reports, the histological grade of Scarff-Bloom-Richardson (SBR) system was proposed, which, later was modified by Nottingham group, in which tumors are graded 1, 2 and 3 according to the structural and cellular findings. In 1991, its prognostic value was demonstrated for the first time and, since then, several studies have validated it, which has made it a classification system recommended worldwide. The aim of this study was to understand the pathological profile of ductal carcinomas of the Maternidade Escola Assis Chateubriant, correlating with age and with axillary metastases. They studied 302 cases of ductal carcinoma patients from Mastology service of Universidade Federal do Ceará - UFC in the period 2005-2014, aged ≤ 50 years and above 50 years. The following morphological characteristics were analyzed: larger diameter of the tumor, axillary metastasis and histological grade. It was determinate histological grade, tubular grade, nuclear grade and mitotic index in axillary metastasis to compare with primary tumor. The average age of patients was 55.6 years. The average tumor size was 3.4 cm. 40 % of the tumors have diameter ≤ 2cm and 60% > 2cm. According to the histological grade, 23.7 % were grade 1, 32.1 % grade 2 and 42% grade 3. 66 % of the cases showed axillary metastasis and 34 % didn’t show. Women with age ≤ 50 years had fewer tumors grade 1 (p = 0.002) compared to grades 2 and 3. Women older than 50 years had more grade 3 tumors (p = 0.002) and more tumors larger than 2 cm of diameter (p <0.001). The presence of metastasis predominated in both age groups when analyzed alone (p < 0.001). When compared to the primary tumor, the axillary metastases showed a higher frequency of histological grade 3 (66,7%), tubular grade 3 (85,5%), nuclear grade 3 (58%) and mitotic index 2 (58%). The tubular formation was minor in axillary metastasis (p=0,04). Based on the above, it is concluded that women older than 50 years had larger and more undifferentiated tumors and women aged ≤ 50 years had less well-differentiated tumors. There was no difference in morphology between these two groups when compared each other. The axillary implants revealed a more disorganized tissue morphology, which formed a lower number of tubules when compared to the breast primary tumors.