Contribuição ao conhecimento químico de Croton pedicellatus Kunth

Detalhes bibliográficos
Ano de defesa: 2012
Autor(a) principal: Lopes, Elton Luz
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Tese
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Não Informado pela instituição
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Link de acesso: http://www.repositorio.ufc.br/handle/riufc/11554
Resumo: The present work describes for the first time the chemical investigation from leaves of Croton pedicellatus Kunth. (Euphorbiaceae), a shrub, native to South America and popularly known as “velame”, name given to several Croton species. The ethanol extract from leaves was subjected to classical chromatographic procedures including high performance liquid chromatography (HPLC), resulting in the isolation of 15 secondary metabolites: two sesquiterpenes known as blumenol A and roseosídeo; five clerodane furan diterpenes: 12,20:15,16-diepoxy-3-hydroxy-7,20-dioxocleroda-13(16),14-dien-18,2-olide; methyl-12,20: 15,16-diepoxy-2,8-dihydroxy-3-acetoxy-7,20-dioxocleroda-13(16),14-dien-18-oate; methyl-12.20:15,16-diepoxy-2-hydroxy-3-acetoxy-7,20-dioxocleroda-13 (16),14-dien-18-oate; methyl-12,20:15,16-diepoxy-3,8- dihydroxy-2-acetoxy-7,20 -dioxocleroda-13(16),14-dien-18-oate; methyl-12,20:15,16-diepoxy-3-hydroxy-2-acetoxy-7,20-dioxocleroda-13(16),14-dien-18-oate, and six flavonoids: alpinumisoflavone, kaempferol, quercetin-3-glucoside, Kaempferol-3-β-D-(6-trans-p-coumaroyl)glucopyranoside (tiliroside), kaempferol-3-β-D-(6-trans-pcoumaroyl)galactopyranoside and kaempferol-3’-methoxy-3-β-D-(6-trans-pcoumaroyl)glucopyranoside, besides the steroids β-sitosterol and its derivative 3-glucosylated. The structure determination of all secondary metabolites isolated was performed by spectrometric techniques such as hydrogen-1 and carbon-13 nuclear magnetic resonance (1H NMR and 13C one/two- dimensional), infrared spectrometry (IR), high resolution mass spectrometry and comparison with literature data.