Análise computacional de sintases da quitina de fungos basidiomicetos

• Ano de defesa: 2010
• Autor(a) principal: Diniz, Marcelo Vera Cruz
• Orientador(a): Góes-Neto, Aristóteles
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Estadual de Feira de Santana
• Programa de Pós-Graduação: Mestrado Acadêmico em Biotecnologia
• Departamento: DEPARTAMENTO DE CIÊNCIAS BIOLÓGICAS
• País: Brasil
• Palavras-chave em Português: sintase da quitina; Basidiomycota; filogenia; redes complexas; biotecnologia
• Palavras-chave em Inglês: chitin synthase; phylogeny; complex networks; biotechnology
• Área do conhecimento CNPq: CIENCIAS BIOLOGICAS
• Link de acesso: http://tede2.uefs.br:8080/handle/tede/1186

One of the main components of the fungal cell wall is the polysaccharide chitin, which is synthesized by the enzyme chitin synthase. Our work aimed to carry out an integrated in silico study of protein sequences of basidiomycotan chitin synthases using methods of comparative analysis of profiles and patterns, phylogenetic analyses, and complex network approach. Initially, we construct a relational database The following products were generated at the end of the project: (I) a relational database containing all complete or partial protein sequences of chitin syntases of Basidiomycota, constructed and validated; (II) identification and characterization of conserved domains of protein sequences; (III) phylogenetic trees of protein sequences; and (IV) complex networks protein sequences of basidiomycotan chitin synthases. The results will subsidize the development, by molecular modelling, of new compounds or chemical modifications of pré-existent compounds, addressed to the inhibition of the chitin synthesis in the cell wall of phytopathogenic Basidiomycota.