TERAPIA TRANSCRANIANA COM LED NOS COMPRIMENTOS DE ONDA 630NM E 904NM NO MODELO DE ACIDENTE VASCULAR ENCEFÁLICO (AVE)

• Ano de defesa: 2021
• Autor(a) principal: Fonseca, Eliane Gonçalves de Jesus
• Orientador(a): Carraro, Emerson
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Estadual do Centro-Oeste
• Programa de Pós-Graduação: Programa de Pós-Graduação em Ciências Farmacêuticas (Doutorado)
• Departamento: Unicentro::Departamento de Farmácia
• País: Brasil
• Palavras-chave em Português: acidente vascular encefálico; LED 630nm; LED 904nm; neurogênese; comportamento motor
• Palavras-chave em Inglês: stroke; 630nm LED; 904nm LED; neurogenesis; motor behavior
• Área do conhecimento CNPq: CIENCIAS DA SAUDE::FARMACIA
• Link de acesso: http://tede.unicentro.br:8080/jspui/handle/jspui/1766

Introduction: The cerebrovascular accident (CVA) is one of the main causes of death worldwide, as well as motor, cognitive and sensory sequelae. Several interventions have been proposed in recent years, as a way to prevent and mainly treat stroke. In this context, the treatment with Photobiomodulation (FBM) through LED (Light Emitting Diode) stands out, which indicates promising results, as it stimulates cell metabolism, increasing cell regenerative potential and promoting neurogenesis. Objective: This study aimed to evaluate the effects of 630nm LED and 904nm LED in animals submitted to ischemic stroke, analyzing the neurogenesis and motor behavior of these animals. Methodology: This is an experimental study with controlled intervention that included a sample of 75 Rattus norvegicus, Wistar, males, divided into 3 groups: a control group consisting of 15 animals without treatment, a group treated with 630nm LED and a group treated with 904nm LED , composed of 30 animals in each treated group. All animals underwent stereotaxic surgery for electrode implantation and subsequent electrolyte injury, and the results were compared at 3, 7 and 21 days of treatment after surgery. Results: In the apprehension, open field and suspension tests show improvement in the motor behavior where there was an increase in strength, endurance, locomotion and functionality and neurogenesis of the animals in both evaluated treatments, as well as histological and immunohistochemical analysis. Conclusion: The present study suggests that the treatments with 630nm LED and 904nm LED favored greater motor response and that they can be promising therapies because they are simple, inexpensive and easy to apply techniques.