Detalhes bibliográficos
| Ano de defesa: |
2014 |
| Autor(a) principal: |
PEREIRA, RICARDO APARECIDO
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| Orientador(a): |
MALFATTI, CARLOS RICARDO MANECK
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| Banca de defesa: |
Não Informado pela instituição |
| Tipo de documento: |
Dissertação
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| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
Universidade Estadual do Centro-Oeste
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| Programa de Pós-Graduação: |
Programa de Pós-Graduação em Ciências Farmacêuticas (Mestrado / Associação Ampla com UEPG)
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| Departamento: |
Unicentro::Departamento de Farmácia
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| País: |
Brasil
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| Palavras-chave em Português: |
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| Palavras-chave em Inglês: |
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| Área do conhecimento CNPq: |
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| Link de acesso: |
http://tede.unicentro.br:8080/jspui/handle/jspui/667
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Resumo: |
Introduction: In recent years diabetes has been gaining major, standing out as a worldwide epidemic. It is a disorder characterized by hyperglycemia and is associated with several complications, dysfunction and failure of various organs. May result from defects in secretion and/or insulin action involving specific pathogenic processes. Due to the large number of cases , the disease causes a huge burden on the public purse. In this sense , special attention has been given to the different levels of disease prevention. To this end, several plant species have been used to treat and or combat the symptoms of diabetes mellitus . The present study utilized methanol extract of Baccharis dracunculifolia popularly known as broom or rosemary - of - field , is widely used in folk medicine . The infusion of the leaves is used for liver problems, stomach disorders and how antiinflammatory. Methods: 24 adult Wistar rats treated for 28 days were used. The animals were divided into 4 groups as follows: CS - Saline Control (treated with a solution of "Tween 80" and distilled water) CP - Control plant (treated with the extract of B. dracunculifolia); DS - Diabetic Saline (induced diabetes , treated with a solution of "Tween 80" and distilled water), SD - diabetic Plant (induced diabetes treated with extract of B. dracunculifolia) . The induction of diabetes was performed by administering 50 mg / kg streptozotocin (STZ). The animals were evaluated for weight gain. At 14◦ day of treatment the animals underwent OGTT, drop of blood flow. At the end of the treatment the animals were euthanized for withdrawal of blood samples and tissues for determination of biochemical parameters, hormonal and preparation of histological slides and quantification of TBARS via malondialdehyde in renal and hepatic tissue. Results and Discussion: There was statistical difference for the DS and DP groups parameters for creatinine (p <0,05) , urea (p < 0.01), and triglycerides (p < 0:01). For creatinine and triglycerides analytes DP was considered statistically equal to the nondiabetic groups (CS and CP). Plasma insulin was statistically significant (p < 0.01), between the diabetic groups, with higher concentrations for the DP . DP on the OGTT , fasting , was statistically comparable with nondiabetic controls (CP and CS) , the following measurements SD was statistically different from all groups , with intermediate values between diabetic nondiabetic groups (CP and CS) and the control group (SD) . The PD group showed a significant reduction in lipid peroxidation when compared to the DS group, this reduction comparable to the non-diabetic groups . The diabetic group treated with extract showed less severe tissue damage when compared to the DS group. Groups of non-diabetic animals (CS and CP) had normal histology. Conclusion: The methanol extract of Baccharis dracunculifolia promoted the decrease of capillary glucose levels of fasting rats induced by STZ diabetes , a decreased value of triglycerides , creatinine and urea STZ -induced animals , the plant extract showed protection from damage to organs (liver , kidneys and pancreas ) induced diabetic animals ; occurred statistical difference in insulin release in diabetic animals where treated animals had higher concentrations. |
