Associa????o entre os polimorfismos BsmI e FokI do gene VDR, n??veis s??ricos de 25(OH)D e susceptibilidade ?? osteoporose em idosas

• Ano de defesa: 2016
• Autor(a) principal: Ramos, Rafaela
• Orientador(a): Vila??a, Karla Helena Coelho
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Cat??lica de Bras??lia
• Programa de Pós-Graduação: Programa Strictu Sensu em Gerontologia
• Departamento: Escola de Sa??de e Medicina
• País: Brasil
• Palavras-chave em Português: Osteoporose; Gerontologia
• Área do conhecimento CNPq: CIENCIAS DA SAUDE
• Resumo em Inglês: Osteoporosis (OP) is a common osteometabolic disease among the elderly and may be associated with genetic components that influence bone metabolism. Due to regulatory action of vitamin D in osteomineral physiology, the expression of the vitamin D receptor gene (VDR) in bone tissue, it is able to influence the genetic determinants of bone mineral density (BMD) and the OP. Studies report the existence of polymorphisms related to the pathogenesis of OP, which can lead to changes in the mechanisms of the action of vitamin D. The BsmI and FokI polymorphisms were associated with changes in BMD suggesting thus a higher incidence and prevalence of fractures due to bone fragility. The objective of this study was to associate the presence of BsmI and FokI polymorphisms located in VDR gene, serum levels of 25(OH)D and susceptibility to OP for elderly women. It was observed that 58% of the study sample had levels of 25(OH)D below the threshold considered sufficient and 62% showed changes in BMD values consistent with the diagnosis of osteopenia or osteoporosis. For elderly women, vitamin D levels are not related to the reduction of BMD and presence of polymorphisms. In the evaluation of polymorphic sites it was found that, in this sample, 28% were positive for FokI polymorphism and 10% were positive for BsmI. The described results show that in elderly women, the BsmI polymorphisms FokI and are not related to vitamin D and osteoporosis.
• Link de acesso: https://bdtd.ucb.br:8443/jspui/handle/tede/2171

Osteoporosis (OP) is a common osteometabolic disease among the elderly and may be associated with genetic components that influence bone metabolism. Due to regulatory action of vitamin D in osteomineral physiology, the expression of the vitamin D receptor gene (VDR) in bone tissue, it is able to influence the genetic determinants of bone mineral density (BMD) and the OP. Studies report the existence of polymorphisms related to the pathogenesis of OP, which can lead to changes in the mechanisms of the action of vitamin D. The BsmI and FokI polymorphisms were associated with changes in BMD suggesting thus a higher incidence and prevalence of fractures due to bone fragility. The objective of this study was to associate the presence of BsmI and FokI polymorphisms located in VDR gene, serum levels of 25(OH)D and susceptibility to OP for elderly women. It was observed that 58% of the study sample had levels of 25(OH)D below the threshold considered sufficient and 62% showed changes in BMD values consistent with the diagnosis of osteopenia or osteoporosis. For elderly women, vitamin D levels are not related to the reduction of BMD and presence of polymorphisms. In the evaluation of polymorphic sites it was found that, in this sample, 28% were positive for FokI polymorphism and 10% were positive for BsmI. The described results show that in elderly women, the BsmI polymorphisms FokI and are not related to vitamin D and osteoporosis.