Detalhes bibliográficos
| Ano de defesa: |
2012 |
| Autor(a) principal: |
Barros, Edilberto dos Santos
 |
| Orientador(a): |
C??rdova, Cl??udio Olavo de Almeida
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| Banca de defesa: |
Não Informado pela instituição |
| Tipo de documento: |
Dissertação
|
| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
Universidade Cat??lica de Bras??lia
|
| Programa de Pós-Graduação: |
Programa Strictu Sensu em Educa????o F??sica
|
| Departamento: |
Escola de Sa??de e Medicina
|
| País: |
Brasil
|
| Palavras-chave em Português: |
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| Área do conhecimento CNPq: |
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| Resumo em Inglês: |
Background: The number of elderly (60 years or more) grows all over the world, for two reasons: increased life expectancy and reducing fertility rates. Furthermore, cardiovascular diseases, particularly atherosclerosis, are the major cause of death in the elderly people. Aging causes changes in the immune system that contribute to a higher incidence of infectious diseases and chronic degenerative diseases. Increased basal levels of cytokines, represent a systemic chronic inflammatory state known Inflammation. In the elderly, the redistribution of tissue calcification is different from the predictive value of coronary artery calcification. Thus, the association of comorbidities caused by aging prevents the extrapolation of knowledge gained in younger populations. Main: To investigate the relantionship between serum levels of cytokines: TNF- , IL-10 and C-Reactive Protein (CRP) with coronary calcification in the very elderly. Materials and methods: Individuals aged between 80 and 102 years (n = 178). Was evaluated plasma cytokines, acute phase proteins, intima-media thickness (IMT), presence of plaques in the carotid arteries by ultrasound and coronary artery calcification (CAC) by computed tomography. Results: There was no association between CAC and carotid plaques(p = 0.8),maximum(p = 0.06) or mean IMT (p = 0.2). No association was found between the presence of carotid plaques and CRP (p = 0.4),TNF- (p = 0.8)orIL-10(p = 0.2).Likewise, individuals in the first three quartiles for CRP, TNF- or IL-10 had similar values of CAC, mean and maximum IMT. In contrast, individuals above the 75 th percentile for CRP or for TNF- had enhanced maximum IMT (p = 0.017and p < 0.0001) and CAC (p = 0.026 and p = 0.01) and subjects with IL-10 levels above the 75th percentile had lower maximum IMT (p = 0.027) and CAC (p = 0.006) as compared with those below this percentile. There was no difference in mean IMT for individuals above or below the 75th percentile for CRP, TNF-A or IL-10. Conclusion: In very old individuals, CAC and maximum IMT were positively associated with systemic inflammatory activity only in those above the 75th percentile. |
| Link de acesso: |
https://bdtd.ucb.br:8443/jspui/handle/tede/2188
|
Resumo: |
Background: The number of elderly (60 years or more) grows all over the world, for two reasons: increased life expectancy and reducing fertility rates. Furthermore, cardiovascular diseases, particularly atherosclerosis, are the major cause of death in the elderly people. Aging causes changes in the immune system that contribute to a higher incidence of infectious diseases and chronic degenerative diseases. Increased basal levels of cytokines, represent a systemic chronic inflammatory state known Inflammation. In the elderly, the redistribution of tissue calcification is different from the predictive value of coronary artery calcification. Thus, the association of comorbidities caused by aging prevents the extrapolation of knowledge gained in younger populations. Main: To investigate the relantionship between serum levels of cytokines: TNF- , IL-10 and C-Reactive Protein (CRP) with coronary calcification in the very elderly. Materials and methods: Individuals aged between 80 and 102 years (n = 178). Was evaluated plasma cytokines, acute phase proteins, intima-media thickness (IMT), presence of plaques in the carotid arteries by ultrasound and coronary artery calcification (CAC) by computed tomography. Results: There was no association between CAC and carotid plaques(p = 0.8),maximum(p = 0.06) or mean IMT (p = 0.2). No association was found between the presence of carotid plaques and CRP (p = 0.4),TNF- (p = 0.8)orIL-10(p = 0.2).Likewise, individuals in the first three quartiles for CRP, TNF- or IL-10 had similar values of CAC, mean and maximum IMT. In contrast, individuals above the 75 th percentile for CRP or for TNF- had enhanced maximum IMT (p = 0.017and p < 0.0001) and CAC (p = 0.026 and p = 0.01) and subjects with IL-10 levels above the 75th percentile had lower maximum IMT (p = 0.027) and CAC (p = 0.006) as compared with those below this percentile. There was no difference in mean IMT for individuals above or below the 75th percentile for CRP, TNF-A or IL-10. Conclusion: In very old individuals, CAC and maximum IMT were positively associated with systemic inflammatory activity only in those above the 75th percentile. |
