Efeitos do treinamento resistido sobre o estresse oxidativo no fígado de ratas ovariectomizadas

Detalhes bibliográficos
Ano de defesa: 2011
Autor(a) principal: Rodrigues, Maria Fernanda Cury
Orientador(a): Perez, Sergio Eduardo de Andrade lattes
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal de São Carlos
Programa de Pós-Graduação: Programa Interinstitucional de Pós-Graduação em Ciências Fisiológicas - PIPGCF
Departamento: Não Informado pela instituição
País: BR
Palavras-chave em Português:
Palavras-chave em Inglês:
Área do conhecimento CNPq:
Link de acesso: https://repositorio.ufscar.br/handle/20.500.14289/1343
Resumo: Estrogen deficiency is associated with increased oxidative stress (OS), which in turn is involved in the physiopathology of diseases such as fatty liver disease (NAFLD). Resistance training (RT) may reduce the oxidative damage by promoting an up-regulation in the antioxidant defence system. Therefore, this study aimed to assess the effects of RT on OS markers in the liver of ovariectomized rats (Ovx). Adult Sprague-Dawley rats were divided into four groups (n = 8 per group): sham-operated sedentary (Sham-Sed), ovariectomized sedentary (Sed-Ovx), sham-operated resistance training (Sham-Rt) and ovariectomized resistance training (Ovx-Rt). During a 10-week RT period, the animals climbed a 1.1 m vertical ladder with weights attached to their tails; the sessions were performed three times a week, with 4-9 climbs and 8-12 dynamic movements per climb. The OS was measured by levels of reduced glutathione (GSH) and oxidized glutathione (GSSG), the enzymatic activity of catalase (CAT) and superoxide dismutase (SOD), the lipid peroxidation (LP), the concentration of vitamin E and gene expression of glutathione peroxidase (GSH-Px). The estrogen deficiency associated with Ovx decreased in the GSH/GSSG ratio (28%), vitamin E concentration (45%), and gene expression of GSH-Px (49%). Moreover, the training induced negative changes in the hepatic anti-oxidative/oxidative balance, as evidenced by the increased TBARS levels (30%), as well as decreased GSH/GSSG ratio (19%) and vitamin E concentration (35%). These data indicate that the RT program adopted did not reverse the hepatic oxidative damage caused by Ovx; indeed, it increased hepatic OS.