Avaliação do papel da proteína STAT3 na infecção Vírus Sincicial Respiratório e resposta de células T CD8 de memória

• Ano de defesa: 2016
• Autor(a) principal: Becker, André Luiz
• Orientador(a): Renato Tetelbom, Renato Tetelbom
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Pontifícia Universidade Católica do Rio Grande do Sul
• Programa de Pós-Graduação: Programa de Pós-Graduação em Medicina/Pediatria e Saúde da Criança
• Departamento: Faculdade de Medicina
• País: Brasil
• Palavras-chave em Português: VIROSES; MEMÓRIA; PEDIATRIA; MEDICINA
• Área do conhecimento CNPq: CIENCIAS DA SAUDE::MEDICINA
• Link de acesso: http://tede2.pucrs.br/tede2/handle/tede/7145

Introduction: The formation of memory T cells is critical in adaptive immunity, when re-exposure to an antigen, it allows immediate response in this new challenge. This condition is very important in infections, vaccines and cancer. CD8 T cells present specific characteristics among the other lymphocytes regarding the formation of its memory cell populations. Recently the complex mechanism of cytokines and transcription factors that direct to the different phenotypic outcomes has been studied. A relevant factor in this process is the activation of signal transducers to the nucleus (STATs), which activate the transcription of DNA. From this group STAT3 (Signaling Transducer and Activator of Transcription 3) seems to have a crucial role in the formation of memory CD8 T cells. Objectives: To deepen the knowledge about the formation of memory T cells, mostly CD8 T cell, through STAT3 protein in this process. Also to review the literature and expand with original experiments the clinical and laboratory approach of immunity to RSV regarding the CD8-STAT3 relationship. Methods: Review article: A search was made in the database using Boolean operators in PUBMED platform on the relationship between STAT3 and development of CD8 memory T cell subsets. The selected articles were analyzed and summarized. Original article: In vitro experiments were performed to analyze the effect of RSV in STAT3 and its relationship with the different memory CD8 T cell profiles. Results: STAT3 is an important part in defining the profile of memory CD8 T cells and undergoes significant changes during RSV infection. Conclusion: STAT plays a central role in the outcome of the memory CD8 T cell development. STAT3 activation and expression are indeed influenced by RSV infection in human and murine models, which suggests new possibilities for therapeutical interventions.