Detalhes bibliográficos
| Ano de defesa: |
2014 |
| Autor(a) principal: |
Zaparte, Aline
 |
| Orientador(a): |
Bauer, Moisés Evandro |
| Banca de defesa: |
Não Informado pela instituição |
| Tipo de documento: |
Dissertação
|
| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
Pontifícia Universidade Católica do Rio Grande do Sul
|
| Programa de Pós-Graduação: |
Programa de Pós-Graduação em Biologia Celular e Molecular
|
| Departamento: |
Faculdade de Biociências
|
| País: |
Brasil
|
| Palavras-chave em Português: |
|
| Área do conhecimento CNPq: |
|
| Link de acesso: |
http://tede2.pucrs.br/tede2/handle/tede/6228
|
Resumo: |
Crack is a cocaine-‐derived substance that acts as a stimulant of the central nervous system. It is characterized by low cost, quick action and high power dependency. Little is known about effects at the cellular level caused by the crack and body resilience of body during period of abstinence. Studies have shown an increased production of reactive oxygen species (ROS) after administration of cocaine. Oxidative stress occurs when there is an imbalance between the production of ROS and the ability of the antioxidant defense in combat or prevent its action. This condition can be harmful to cells, causing damage to biomolecules such as DNA, lipids and proteins. Aiming to better understand the action of crack and abstinence in redox state, this study enrolled thirty patients of program for detoxification and thirty volunteers who did not use drugs taken as control group. Blood samples were collected after 4th and the 18th day of treatment and plasma was used for biochemical analysis. Quantifications were performed oxidants markers such as protein carbonyl and protein thiols, both demonstrate protein modifications by ROS, and antioxidant markers such as glutathione peroxidase and superoxide dismutase and non-‐enzymatic markers such reduced glutathione (GSH) and total reactive antioxidant potential (TRAP).Psychological variables were assessed through the scores obtained Cocaine Selective Severity Assessment, Fagerstrom Tolerance Questionnaire, Beck Depression Inventory version II (BDI-‐II) and Addiction Severity Index. After four days of abstinence we observe observed an increase in oxidative markers compared to end of the treatment. After eighteen days of abstinence there is a recovery of antioxidant defenses. Also, we observed e a positive correlation between protein carbonyls and psychological variables and a negative correlation between the levels of TRAP levels and psychological variables. Thus, our results suggest that abstinence period may provide a recovery of antioxidant defenses, thereby reducing propensity for oxidative damage. |
