Detalhes bibliográficos
| Ano de defesa: |
2015 |
| Autor(a) principal: |
Fernandes, Bruna |
| Orientador(a): |
Santos, Marlise Araújo dos
 |
| Banca de defesa: |
Não Informado pela instituição |
| Tipo de documento: |
Dissertação
|
| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
Pontifícia Universidade Católica do Rio Grande do Sul
|
| Programa de Pós-Graduação: |
Programa de Pós-Graduação em Biotecnologia Farmacêutica
|
| Departamento: |
Faculdade de Farmácia
|
| País: |
Brasil
|
| Palavras-chave em Português: |
|
| Área do conhecimento CNPq: |
|
| Link de acesso: |
http://tede2.pucrs.br/tede2/handle/tede/6150
|
Resumo: |
Several companies wordwide produce kits with 99mTc labelling for diagnosing neuroendocrine tumors. Aiming at producing this kind of product in Brazil, a formulation was proposed, based on the methodology developed by Guggenberg et ul, using HYNIC-TOC, SnCl2, EDDA, tricine, mannitol and ascorbic acid. For labelling the cold kit, metastable radionuclide technetium (99mTc), produced by a 99Mo generator was used. The product was stored at temperatures of 0 to 8°C and at 25°C before labelling. After the product was labelled, it was kept at room temperature for up to 4 hours. The time of exposure was sufficient to observe the shelf life of the product for each storage method. Considering a radiochemical purity (RCP) of 80%, the product remained stable during the eight-month storage at 0 to 8°C before labelling and up to 4 hours after labelling. Therefore, the use of this product is possible in centers of nuclear medicine for a longer period during the day. |
