Comparação e associação de marcadores inflamatórios, do metabolismo redox e gasto calórico entre idosos com e sem déficit cognitivo

• Ano de defesa: 2014
• Autor(a) principal: Nogueira, Guilherme Marcos
• Orientador(a): Gottlieb, Maria Gabriela Valle
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Pontifícia Universidade Católica do Rio Grande do Sul
• Programa de Pós-Graduação: Programa de Pós-Graduação em Gerontologia Biomédica
• Departamento: Instituto de Geriatria e Gerontologia
• País: BR
• Palavras-chave em Português: MEDICINA; GERONTOLOGIA; GERIATRIA; COGNIÇÃO; INFLAMAÇÃO; ATIVIDADES MOTORAS; EXERCÍCIOS FÍSICOS - IDOSOS
• Área do conhecimento CNPq: CNPQ::CIENCIAS DA SAUDE::MEDICINA
• Link de acesso: http://tede2.pucrs.br/tede2/handle/tede/2730

Introduction: the cognitive decline (DC) has a multifactorial etiology. Some studies have suggested that inflammation, oxidative stress and physical activity are associated with the DC. However, evidence of this issue are still controversial. Objective: to compare and verify the association of inflammatory, redox metabolism markers and caloric expenditure between older people with and without cognitive deficit assisted by the Family Health Strategy of the municipality of Porto Alegre. Methods: Cross-sectional study. The sample consisted of 424 older adults (224 with normal cognitive function and 220 with cognitive impairment) patients of the Family Health Program in Porto Alegre, Rio Grande do Sul, Brazil. The variables investigated were: sociodemografia, biochemical markers, inflammatory (CRP, IL - 6) and oxidation (TBARS, AOPP and FRAP), energy expenditure and cognitive function. The instruments used were the following: for the assessment of physical activity was used the Minnesota Leisure Time Physical Activity Questionnaire and the measurement of energy expenditure (METs) Compendium of physical activities was used: classification of energy costs of human physical activities, and used for final analysis of the converted values in Kcal. For the assessment of cognitive ability Bateira one of neuropsychiatric instruments was applied. Results: significant statistical differences were observed between the groups with respect to biochemical, (except to HDL-C, p=0,006) inflammatory, oxidative and antioxidant power markers investigated. Statistical differences were found in age (p=0,002), IL-6 (p=0,020) and time spent in physical activity (< 0.001) with respect to energy expenditure in the elderly. No association was found between caloric expenditure and cognition (p=0,282). To do so, when considering the statistical treatment using logistic regression, this study showed only association of cognitive impairment with age and HDL-C. Conclusions: the results suggest that biochemical (except to HDL-C), inflammatory, oxidative, antioxidant power markers and energy expenditure are not associated with cognitive deficits in the older individuals. Only age and HDL-C were associated with cognitive impairment in this sample.