Detalhes bibliográficos
| Ano de defesa: |
2016 |
| Autor(a) principal: |
Medeiros, Filipe Mello
 |
| Orientador(a): |
Mestriner, Régis Gemerasca
|
| Banca de defesa: |
Não Informado pela instituição |
| Tipo de documento: |
Dissertação
|
| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
Pontifícia Universidade Católica do Rio Grande do Sul
|
| Programa de Pós-Graduação: |
Programa de Pós-Graduação em Biologia Celular e Molecular
|
| Departamento: |
Faculdade de Biociências
|
| País: |
Brasil
|
| Palavras-chave em Português: |
|
| Área do conhecimento CNPq: |
|
| Link de acesso: |
http://tede2.pucrs.br/tede2/handle/tede/6909
|
Resumo: |
Suffer traumatic experiences are a risk factor for developing neuropsychiatric movement disorders. In the present study, we test the hypothesis that aversive, resistant to extinction memories could impair skilled walking performance and change neuron and glia densities as well as neuron-glia ratio in medial amygdala in male Wistar rats. Thus, we established a major trauma protocol able to induce a resistant to extinction memory followed by testing its effects on skilled walking performance and medial amygdala histophysiology. Footshocks exposure reduces skilled walking performance 3 days after the hit (P<0.0001). Additionally, the adoption of a “safety behavior” in the plus maze test was associated with worse ladder walking performance (P<0.001). Statistical trend of significance were founded for changing glia (P=0.10) and neuron-glia ratio (P=0.08) in medial amygdala as well as for their correlation with sensorimotor performance (P=0.06). Therefore, suffering traumatic experiences able to generate resistant to extinction memories could result in long-term impairment of gait control, which affects the walking ability. |
