Uso de surfactante em modelo experimental de Síndrome de Aspiração de Mecônio

• Ano de defesa: 2009
• Autor(a) principal: Colvero, Mauricio Obal
• Orientador(a): Fiori, Humberto Holmer
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Pontifícia Universidade Católica do Rio Grande do Sul; Porto Alegre
• Palavras-chave em Português: MEDICINA; SURFACTANTES PULMONARES; LAVAGEM BRONCOALVEOLAR; RECÉM-NASCIDO; NEONATOLOGIA; ASPIRAÇÃO DE MECÔNIO
• Link de acesso: http://hdl.handle.net/10923/4637

Introduction: although it is becoming less frequent, meconium aspiration syndrome is still a common cause of severe respiratory distress in term neonates. Meconium has an inhibitory effect over the surfactant system and the bronchoalveolar lavage and surfactant replacement have been studied in recent years. Objective: to evaluate the effect of bronchoalveolar lavage with diluted surfactant followed by a supplementary dose of surfactant in a piglet model of meconium aspiration syndrome. Methods: 25 newborn piglets were used in the study. The animals were artificially ventilated with fixed settings throughout the study. After istillation of 5ml/kg of meconium diluted to 20% in isotonic saline, the piglets were randomized in the following groups: group I (n=9) - control; group II (n=6) - bronchoalveolar lavage with diluted surfactant (15ml/kg); group III (n=5) - bronchoalveolar lavage with diluted surfactant (15ml/kg) followed by a supplementary dose of surfactant (Curosurf® 100mg/kg); and group IV (n=5) – dose of surfactant without bronchoalveolar lavage. Arterial blood gases sample were obtained 30 minutes and 3 hours after the inhalation of meconium. Results: values for PaO2 were significantly higher at 30 min after meconium aspiration in the animals from group III compared to group I [ PaO2 44+27 and 10+11 respectively (p=0,005)]. Three hours after the intervention, the oxygenation in group III was also better then in the control group [ PaO2 69+65 e 12+21, respectively (p=0,03)]. Conclusion: bronchoalveolar lavage with diluted surfactant followed by a supplementary dose of surfactant improves oxygenation in experimental piglet model of meconium aspiration syndrome.