Angiogênese de ferida cirúrgica em língua de rato: análise por meio de microscopia eletrônica de varredura de modelo vascular

• Ano de defesa: 2006
• Autor(a) principal: Verli, Flaviana Dornela
• Orientador(a): Souza, Maria Antonieta Lopes de
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Pontifícia Universidade Católica do Rio Grande do Sul; Porto Alegre
• Palavras-chave em Português: ODONTOLOGIA; CICATRIZAÇÃO (ODONTOLOGIA); MICROSCOPIA ELETRÔNICA; LÍNGUA (ODONTOLOGIA)
• Link de acesso: http://hdl.handle.net/10923/577

The vascular corrosion cast technique associated with SEM (Scanning Electron Microscopy) is a suitable method to define the angioarchitecture of different organs and to verify the development of intussusceptive angiogenesis. The capillary lumen is casted with resin and the surrounding tissues are corroded with alkaline solution. The aim of this study was to describe the vascular pattern of the tongue ventral surface from Wistar rats submitted or not to a surgery in the region and to verify the development of sprouting and intussusceptive angiogenesis during wound healing in different postsurgical periods. Tongue’s ventral surface from control rats showed a loose net with small mesh as a superficial capillary plexus and anatomical variations of the confluent vessels of the ranina veins. Rats subjected to surgery showed, on the first postsurgical day, sectioned capillary vein and artery extremities to be conically and round respectively. A process of intussusceptive and sprouting angiogenesis involving the blood vessels of the wound healing was observed on the second day following surgery. On the third postsurgical day the same process of the angiogenesis was observed in the granulation tissue. On the seventh postsurgical day, a complete vascularization of the wound capillary bed was achieved, showing parallel running blood vessels perpendicular to the superficial capillary plexus. On the fourteenth postsurgical day, the central blood capillary vessels presented a radial arrangement from the center of the wound. On day twenty-one after surgery the pattern of the superficial vasculature has not achieved previous pre surgical pattern of blood vessels. Intussusceptive and sprouting angiogenesis occurs more frequently on the root end of surgical wound in the tongue and mainly in the second and third postsurgical days.