An??lise dos efeitos do laser de baixa pot??ncia relacionados ao estresse oxidativo de ratos idosos submetidos ao treinamento aer??bio

Detalhes bibliográficos
Ano de defesa: 2014
Autor(a) principal: Guaraldo, Simone Adriana lattes
Orientador(a): Carvalho, Paulo de Tarso Camillo de lattes
Banca de defesa: Carvalho, Paulo de Tarso Camillo de lattes, Uchiyama, Tatiana de Sousa da Cunha lattes, Leal Junior, Ernesto Cesar Pinto lattes
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Nove de Julho
Programa de Pós-Graduação: Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o
Departamento: Sa??de
País: Brasil
Palavras-chave em Português:
Palavras-chave em Inglês:
Área do conhecimento CNPq:
Link de acesso: http://bibliotecatede.uninove.br/handle/tede/1350
Resumo: Purpose: The aim of the present study was to determine whether low-level laser therapy (LLLT), when used in conjunction with aerobic training, interferes with the oxidative stress, thereby influencing the performance of old rats participating in swimming. Materials and Methods: A total of 30 Wistar rats (norvergicos albinus) were used for this study: 24 aged rats, and 6 young rats. The older animals were randomly divided into 4 groups designated as follows: Aged-Control, Aged-Exercise, Aged-LLLT, Aged-LLLT/Exercise group and. Young-Control animals. Aerobic capacity (VO2 0.75max) was analyzed after and before the training period. The Aged-Exercise and Aged-LLLT/Exercise groups were trained for 6 weeks. LLLT laser was applied at 808 nm and 4 joules of energy to the indicated groups throughout training. The rats were euthanized, and muscle tissue were collected for analysis the index of lipid peroxidation (TBARs), glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) activity. Results: Statistically significant differences in VO2 0.75max values were observed for the Aged-LLLT/Exercise group compared to the baseline older group (p <0.01) and compared with LLLT and exercise group (p <0.05).. The results indicate that the activity of antioxidant enzymes catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) was superior and statistically significant (p <0.05) in the association of LLLT and exercise when compared to the LLLT group and group exercise. Was also observed that young animals presented for the activity of antioxidant enzymes smaller and statistically significant values the Aged group. The LLLT plus exercise and only the LLLT and training (exercise group) was also able to mitigate the concentration of TBARS with (p> 0.05). Conclusion: These results suggest that laser therapy in conjunction with aerobic training may provide a therapeutic approach for reducing oxidative stress, as well as the increase in VO2 0.75max allometric, indicating along with increasing speed media improved performance in aged animals treated with LLLT associated with aerobic training by swimming.