Detalhes bibliográficos
| Ano de defesa: |
2008 |
| Autor(a) principal: |
Santos, Alecsandra Aparecida dos
 |
| Orientador(a): |
Silva, Carlos Alberto |
| Banca de defesa: |
Ferrari, Raquel Agnelli Mesquita
,
Pontako, Fernanda |
| Tipo de documento: |
Dissertação
|
| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
Universidade Nove de Julho
|
| Programa de Pós-Graduação: |
Programa de P??s-Gradua????o em Ci??ncias da Reabilita????o
|
| Departamento: |
Sa??de
|
| País: |
BR
|
| Palavras-chave em Português: |
|
| Palavras-chave em Inglês: |
|
| Área do conhecimento CNPq: |
|
| Link de acesso: |
http://bibliotecatede.uninove.br/tede/handle/tede/806
|
Resumo: |
The increased expression of matrix metalloproteinases (MMPs) is considered to be a key factor in the development of COPD. We performed this study to quantify the expression of MMP-2 and MMP-9 in saliva of COPD patients and healthy controls, and to evaluate feasibility of saliva compounds as a biological material source for the study of biomarkers in COPD. Methods: COPD patients (n=16) and healthy controls (n=9) were selected. In the both group spirometry test was performed and saliva samples were obtained from each subject. The saliva levels of MMP-2 and MMP-9 were determined by Western Blot. Results: MMP-2 and MMP-9 were significantly higher in COPD patients than in control subjects. MMP-2 concentration was correlated negatively with forced expiatory volume in one second (FEV1) (r= -0,582; p= 0,014) in COPD patients. Conclusion: The current findings open new perspectives to study specific biomarkers in saliva to predict and monitor airway obstruction in COPD patients |
