Detalhes bibliográficos
| Ano de defesa: |
2021 |
| Autor(a) principal: |
Pinto, Walter Pereira
 |
| Orientador(a): |
Dalboni, Maria Aparecida
|
| Banca de defesa: |
Dalboni, Maria Aparecida
,
Elias, Rosilene Motta
,
Correia, Marilia de Almeida
,
Grabulosa, Caren Cristina
,
Custódio, Melani Ribeiro
|
| Tipo de documento: |
Tese
|
| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
Universidade Nove de Julho
|
| Programa de Pós-Graduação: |
Programa de Pós-Graduação em Medicina – Ciências da Saúde
|
| Departamento: |
Saúde
|
| País: |
Brasil
|
| Palavras-chave em Português: |
|
| Palavras-chave em Inglês: |
|
| Área do conhecimento CNPq: |
|
| Link de acesso: |
http://bibliotecatede.uninove.br/handle/tede/3333
|
Resumo: |
Introduction: Chronic kidney disease (CKD) is now recognized as a public health. The presence of uremic toxins that are not fully dialyzed by HD induces greater synthesis of inflammatory cytokines and oxidative stress, which contribute to muscle catabolism, leading to loss of muscle mass. The loss of muscle mass in this population has been associated with greater morbidity and mortality. Hemodiafiltration (HDF) has been described as a dialysis modality that promotes greater clearance of uremic toxins. Thus, the aim of this study was to evaluate the effect of HDF on uremic toxins, inflammatory mechanism and its impact on muscle mass in elderly patients with CKD incident on HDF. Methods: Thirty-one elderly patients ≥65 years old who were undergoing HD treatment and were transferred to HDF, evaluated at baseline and 6 months after HDF, were selected for convenience. We evaluated: C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), interleukin-10 (IL-10), serum muscle mass markers: myostatin and irisin, by ELISA, and the uremic toxins indoxyl sulfate (IS), p-cresyl sulfate (PCS) and indole acetic acid (IAA) by high-performance chromatography (HPLC). Results: Six months after starting HDF, we observed a significant reduction in serum IS levels (p < 0.01). We did not observe significant differences in serum concentrations of IL-6, IL-10, TNF-α, CRP, myostatin and irisin after 6 months of HDF. Conclusion: This was the first study to show that after 6 months of HDF there was a reduction in the serum concentration of IS in elderly patients with CKD. However, this result had no influence on inflammation and muscle mass biomarkers. The impact of this finding in the medium and long term must be evaluated in a future study. |
