Reprodutibilidade da pressão arterial, rigidez arterial e modulação autonômica cardíaca em pacientes com doença de Parkinson

Detalhes bibliográficos
Ano de defesa: 2023
Autor(a) principal: Lima, Verônica de Fátima Souza lattes
Orientador(a): Dias, Raphael Mendes Ritti lattes
Banca de defesa: Dias, Raphael Mendes Ritti lattes, Silva, Soraia Micaela lattes, Batista, Carla da Silva lattes
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Nove de Julho
Programa de Pós-Graduação: Programa de Pós-Graduação em Ciências da Reabilitação
Departamento: Saúde
País: Brasil
Palavras-chave em Português:
Palavras-chave em Inglês:
Área do conhecimento CNPq:
Link de acesso: http://bibliotecatede.uninove.br/handle/tede/3272
Resumo: Parkinson's disease (PD) is a neurodegenerative disease and presents non-motor alterations such as cardiovascular ones. The reproducibility of cardiovascular measurements in PD has not yet been investigated. Thus, we verified the reproducibility of blood pressure (BP) and cardiac autonomic modulation (MAC) in patients with PD. For this purpose, 20 male patients with PD (65±7 years old) were evaluated in three visits. Systematic error was obtained by 1way ANOVA, reliability by intraclass correlation coefficient (ICC) and agreement by BlandAltman limits of agreement. P<0.05 was considered significant. The minimum detectable difference was calculated. Heart rate (Polar V800 monitor), brachial and central blood pressure (auscultatory method and pulse wave analysis), MAC (heart rate variability) and arterial stiffness (pulse wave velocity) were obtained. There was a systematic error in the measurement of visit 1 compared to visit 2 (122±3 vs 116±4, p<0.05) of brachial and aortic systolic BP. The ICC ranged from 0.89 to 0.92 (for aortic and brachial BP), mean differences and Bland-Altman limits of agreement were lower when comparing visits 2 and 3. Regarding MAC and arterial stiffness there was a greater variation of measurements with low reliability. Regarding PWV, there was an ICC of 0.89. In conclusion, brachial and aortic BP seem to represent a reproducible measurement at rest in men with PD and the other measurements, in this study, showed a wide range of measurements, with less reproducible data.