Detalhes bibliográficos
Ano de defesa: |
2008 |
Autor(a) principal: |
Freitas, Olavo de Carvalho
 |
Orientador(a): |
Cipullo, José Paulo
 |
Banca de defesa: |
Martin, Jose Fernando Vilela
,
Ramires, Jose Antonio Franchini
,
Braile, Domingo Marcolino
,
Chagas, Antonio Carlos Palandri
,
Ayoub, Jose Carlos Aidar
 |
Tipo de documento: |
Tese
|
Tipo de acesso: |
Acesso aberto |
Idioma: |
por |
Instituição de defesa: |
Faculdade de Medicina de São José do Rio Preto
|
Programa de Pós-Graduação: |
Programa de Pós-Graduação em Ciências da Saúde::123123123123::600
|
Departamento: |
Medicina Interna; Medicina e Ciências Correlatas::123123123123::600
|
País: |
BR
|
Palavras-chave em Português: |
|
Área do conhecimento CNPq: |
|
Link de acesso: |
http://bdtd.famerp.br/handle/tede/52
|
Resumo: |
The renin-angiotensin system activation has been regarded as more and more important, namely interaction with obesity, by accumulation of visceral adipose tissue, a major risk for hypertension development. Obesity is associated with several abnormalities, such as sodium retention, renal hyperfiltration, left ventricular hypertrophy and microalbuminuria. Objective: To evaluate kidney and heart remodeling, following pharmacological double blockade of the renin-angiotensin system, in spontaneously hypertensive rats, and in normotensive and spontaneously hypertensive obese-induced adult rats. Material and Method: Forty spontaneously hypertensive Wistar rats were subdivided into 4 groups of 10, as follows: 10 animals were treated with pharmacological double blockade of the renin-angiotensin system, and received enalapril and losartan for 4 weeks; 10 non-blocked; 10 rats rendered obese in adult life by means of a hypercaloric diet without block, and 10 hypertensive obese-induced, blocked animals. Forty normotensive rats (controls) were subdivided into 4 groups of 10 animals, as follows: 10 normal rats; 10 normal and blocked; 10 obese-induced without block and 10 obese-induced, blocked. Blood pressure, heart and kidney weights (relatively to body weight), heart and kidney collagen levels, and proteinuria, were evaluated in all animals. Results: Increased heart and kidney weight/body weight and tissue collagen and proteinuria levels were found in hypertensive and obese-hypertensive rats. Pharmacological double blockade of the renin-angiotensin system brought significant reduction (CI 95 %) in heart weight/body weight in obese-hypertensive rats, and reduction of renal collagen levels and proteinuria in hypertensive and obese-hypertensive rats. The normotensive obese rats increased renal collagen levels and proteinuria. Such changes were significantly reduced (CI 95 %) by means of renin-angiotensin system blocked. Conclusions: Pharmacological double blockade of the renin-angiotensin system brings benefits, particularly, to kidney remodeling, with reduction of the proteinuria in hypertensive, hypertensive-obese and normotensive-obese rats. |