Avaliação do bloqueio duplo do sistema renina-angiotensiva e remodelações cardíaca e renal, em ratos espontaneamente hipertensos, obesos e não obesos

• Ano de defesa: 2008
• Autor(a) principal: Freitas, Olavo de Carvalho
• Orientador(a): Cipullo, José Paulo
• Banca de defesa: Martin, Jose Fernando Vilela , Ramires, Jose Antonio Franchini , Braile, Domingo Marcolino , Chagas, Antonio Carlos Palandri , Ayoub, Jose Carlos Aidar
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Faculdade de Medicina de São José do Rio Preto
• Programa de Pós-Graduação: Programa de Pós-Graduação em Ciências da Saúde::123123123123::600
• Departamento: Medicina Interna; Medicina e Ciências Correlatas::123123123123::600
• País: BR
• Palavras-chave em Português: Renina-Angiotensina; Obesidade
• Área do conhecimento CNPq: CNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA::CARDIOLOGIA::123123123123::600
• Link de acesso: http://bdtd.famerp.br/handle/tede/52

The renin-angiotensin system activation has been regarded as more and more important, namely interaction with obesity, by accumulation of visceral adipose tissue, a major risk for hypertension development. Obesity is associated with several abnormalities, such as sodium retention, renal hyperfiltration, left ventricular hypertrophy and microalbuminuria. Objective: To evaluate kidney and heart remodeling, following pharmacological double blockade of the renin-angiotensin system, in spontaneously hypertensive rats, and in normotensive and spontaneously hypertensive obese-induced adult rats. Material and Method: Forty spontaneously hypertensive Wistar rats were subdivided into 4 groups of 10, as follows: 10 animals were treated with pharmacological double blockade of the renin-angiotensin system, and received enalapril and losartan for 4 weeks; 10 non-blocked; 10 rats rendered obese in adult life by means of a hypercaloric diet without block, and 10 hypertensive obese-induced, blocked animals. Forty normotensive rats (controls) were subdivided into 4 groups of 10 animals, as follows: 10 normal rats; 10 normal and blocked; 10 obese-induced without block and 10 obese-induced, blocked. Blood pressure, heart and kidney weights (relatively to body weight), heart and kidney collagen levels, and proteinuria, were evaluated in all animals. Results: Increased heart and kidney weight/body weight and tissue collagen and proteinuria levels were found in hypertensive and obese-hypertensive rats. Pharmacological double blockade of the renin-angiotensin system brought significant reduction (CI 95 %) in heart weight/body weight in obese-hypertensive rats, and reduction of renal collagen levels and proteinuria in hypertensive and obese-hypertensive rats. The normotensive obese rats increased renal collagen levels and proteinuria. Such changes were significantly reduced (CI 95 %) by means of renin-angiotensin system blocked. Conclusions: Pharmacological double blockade of the renin-angiotensin system brings benefits, particularly, to kidney remodeling, with reduction of the proteinuria in hypertensive, hypertensive-obese and normotensive-obese rats.