Desenvolvimento de um modelo experimental clássico para o estudo da fisiopatologia da PAIR

• Ano de defesa: 2005
• Autor(a) principal: Mioto, Cristiane Sampaio
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade de Franca; Brasil; Pós-Graduação; Programa de Mestrado em Promoção de Saúde; UNIFRAN
• Palavras-chave em Português: Fonoaudiologia - Perda auditiva induzida por ruido (PAIR); Pair (fisiopatologia) - Modelo experimental - Estudo; Emissão otoacústica por produto de distorção (EOAPD); CNPQ::CIENCIAS DA SAUDE::FONOAUDIOLOGIA
• Link de acesso: https://repositorio.cruzeirodosul.edu.br/handle/123456789/528

Noise-Induced Hearing Loss (PAIR), although poorly understood in its pathophysiological aspects, can currently be considered as one of the most common causes of hearing loss in adult humans, however, we do not yet have an established experimental model for this disease. For several authors, the susceptibility to PAIR characterizes a marked inter and intra-individual variation. The variability of PAIR has been reported to be due to numerous factors such as: individual variations of the ear for the transmission of sound, structural properties, nutritional and blood supply, stress, age, effect of drugs on the cochlea and melanic pigmentation. Therefore, the objective of this work was to evaluate the development of experimental deafness in guinea pigs (Chinchillas) with normal hearing exposed to intense noise and to compare them to a control group. 20 ears of ten guinea pigs from the Otoacoustic Emission test (EOA) per distortion product (EOAPD) will be evaluated for representing a more specific cochlear response at each frequency. These guinea pigs were carefully selected, initially evaluated through the Preyer reflex and EOAPD under general anesthesia and, if normal, after seven days stimulated in 1095 dBA with white noise continuously for 2 hours, for a second and immediate evaluation through the EOAPD; then a third assessment was made one week later. The results were compared to those found in the control group, composed of 20 ears of ten guinea pigs, submitted to the same procedure with the exception of noise exposure. After the experiment in guinea pigs, we concluded that it was successful in causing a typical PAIR deafness, similar to that found in humans, and that this method is easy to apply and with great potential for future experiments that may in the future bring answers to countless open questions about this important nosological entity, which continues to grow rapidly in our country, despite tireless and laborious preventive efforts.