A ativação imunológica materna na gênese do comportamento autista: aspectos comportamentais e neuroquímicos

• Ano de defesa: 2014
• Autor(a) principal: Soares, Evandro da Cruz Cittadin
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Palavras-chave em Português: Barreira hematoencefálica; Autismo; Ativação imune materna; Neuroinflamação
• Link de acesso: https://repositorio.animaeducacao.com.br/handle/ANIMA/3147

The Autistic Spectrum Disorder (ASD) is a neuropsychiatric disorder developed in early childhood, characterized by severe and pervasive impairment in the domains of development areas relevant to social interaction, communication, behavior and interests. It has an estimated global prevalence of 0.62% and its dianóstico remains exclusively based on clinical observation, without yet no supplementary exam available to support it. In recent years, environmental interferences have been identified as possible causes for the development of ASD since clinical evidence demonstrating a correlation between the disorder and the incidence of maternal infections or autoimmune diseases in the perinatal period. Animal models of autism using prenatal infections point to the importance of immune activation in the developing brain. Rats exposed to lipopolysaccharide (LPS) in the prenatal period have reduced play behavior and decreased social interaction when youth and adults. The aim of this study was to investigate the inflammatory response in the offspring of rats submitted to an animal model of autism induced by LPS in the prenatal period, where pregnant females were given LPS intraperitoneally at a dose of 100 mg / kg to 9.5 days of gestation. The results showed that prenatal exposure to LPS was able to induce autistic behavior in offspring, altering the permeability of brain barrier, elevate the levels of cytokines in brain structure, and increase the levels of malondialdehyde and decrease antioxidant defenses. Taken together, these results suggest that prenatal insult is able to interfere in the development and activity of the nervous system of the pups in the long term, producing behavioral and neurochemical changes similar to those found in ASD.