A nefrotoxicidade da polimixina B
Gardado en:
| Autor Principal: | |
|---|---|
| Data de Publicación: | 2022 |
| Formato: | Bachelor thesis |
| Idioma: | por |
| Fonte: | Repositório Institucional da UPF |
| Download full: | https://repositorio.upf.br/handle/123456789/7432 |
Summary: | Polymyxin B is part of an ancient class of antimicrobials used to fight infections originating from multidrug-resistant gram-negative bacteria. Despite being a great treatment option, it has a cytotoxic profile that affects renal cells, with nephrotoxicity being one of the most limiting adverse events due to the dose and the worsening of the clinical condition of affected patients, triggering acute kidney injury in the vast majority of cases. . In this context, an integrative review was carried out, with the objective of evaluating the scientific literature on the nephrotoxicity of polymyxin B and the consequences caused to individuals who are affected by kidney damage after the use of the antibiotic. Scientific articles were selected from the PUBMED database, using “Polymyxin B AND nephrotoxicity” as descriptors and with a time span of 5 years. From the review, it was found that acute kidney injury induced by polymyxin B nephrotoxicity generates significant impact on adult or pediatric patients, such as longer hospitalization, long-term consequences and increased risk of mortality. Discontinuing the antimicrobial proved to be the most effective option to manage kidney damage, but, in fact, the best way to preserve the integrity of kidney function is to avoid toxic events through follow-up, strict assistance to individuals and not using concomitant polymyxin B to other nephrotoxic agents during this period. In pediatric patients, the incidence of nephrotoxicity is high and therefore treatment with polymyxin B should be an option in last cases with intense monitoring. |
| _version_ | 1871607639941578752 |
|---|---|
| author | Mezzomo, Regina |
| author_browse | Mezzomo, Regina |
| author_facet | Mezzomo, Regina |
| author_role | author |
| collection | Repositório Institucional da UPF |
| dc.contributor.author.fl_str_mv | Mezzomo, Regina |
| dc.contributor.none.fl_str_mv | Grando, Luciana Grazziotin Rossato |
| dc.date.none.fl_str_mv | 2022-12-12 2025-05-10T22:24:00Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.uri.fl_str_mv | MEZZOMO, Regina. A nefrotoxicidade da polimixina B. 2022. 28 f. Trabalho de Conclusão de Curso (Farmacêutico). Curso de Farmácia. Universidade de Passo Fundo, Passo Fundo, 2022. https://repositorio.upf.br/handle/123456789/7432 |
| dc.language.iso.fl_str_mv | por |
| dc.publisher.none.fl_str_mv | Universidade de Passo Fundo Instituto de Ciências Biológicas - ICB Brasil UPF |
| dc.rights.driver.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:Repositório Institucional da UPF instname:Universidade de Passo Fundo (UPF) instacron:UPF |
| dc.subject.por.fl_str_mv | Farmácia Polimixina B Lesão renal Manejo Nefrotoxicidade |
| dc.title.none.fl_str_mv | A nefrotoxicidade da polimixina B |
| dc.type.driver.fl_str_mv | info:eu-repo/semantics/bachelorThesis |
| dc.type.status.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Polymyxin B is part of an ancient class of antimicrobials used to fight infections originating from multidrug-resistant gram-negative bacteria. Despite being a great treatment option, it has a cytotoxic profile that affects renal cells, with nephrotoxicity being one of the most limiting adverse events due to the dose and the worsening of the clinical condition of affected patients, triggering acute kidney injury in the vast majority of cases. . In this context, an integrative review was carried out, with the objective of evaluating the scientific literature on the nephrotoxicity of polymyxin B and the consequences caused to individuals who are affected by kidney damage after the use of the antibiotic. Scientific articles were selected from the PUBMED database, using “Polymyxin B AND nephrotoxicity” as descriptors and with a time span of 5 years. From the review, it was found that acute kidney injury induced by polymyxin B nephrotoxicity generates significant impact on adult or pediatric patients, such as longer hospitalization, long-term consequences and increased risk of mortality. Discontinuing the antimicrobial proved to be the most effective option to manage kidney damage, but, in fact, the best way to preserve the integrity of kidney function is to avoid toxic events through follow-up, strict assistance to individuals and not using concomitant polymyxin B to other nephrotoxic agents during this period. In pediatric patients, the incidence of nephrotoxicity is high and therefore treatment with polymyxin B should be an option in last cases with intense monitoring. |
| eu_rights_str_mv | openAccess |
| format | bachelorThesis |
| id | UPF_ae9bbcfedb9d5c7c0e90c6d62e4e19b5 |
| identifier_str_mv | MEZZOMO, Regina. A nefrotoxicidade da polimixina B. 2022. 28 f. Trabalho de Conclusão de Curso (Farmacêutico). Curso de Farmácia. Universidade de Passo Fundo, Passo Fundo, 2022. |
| instacron_str | UPF |
| institution | UPF |
| instname_str | Universidade de Passo Fundo (UPF) |
| language | por |
| network_acronym_str | UPF |
| network_name_str | Repositório Institucional da UPF |
| oai_identifier_str | oai:repositorio.upf.br:123456789/7432 |
| publishDate | 2022 |
| publishDateSort | 2022 |
| publisher.none.fl_str_mv | Universidade de Passo Fundo Instituto de Ciências Biológicas - ICB Brasil UPF |
| reponame_str | Repositório Institucional da UPF |
| repository.mail.fl_str_mv | jucelei@upf.br||biblio@upf.br |
| repository.name.fl_str_mv | Repositório Institucional da UPF - Universidade de Passo Fundo (UPF) |
| repository_id_str | 1610 |
| spelling | A nefrotoxicidade da polimixina BFarmáciaPolimixina BLesão renalManejoNefrotoxicidadePolymyxin B is part of an ancient class of antimicrobials used to fight infections originating from multidrug-resistant gram-negative bacteria. Despite being a great treatment option, it has a cytotoxic profile that affects renal cells, with nephrotoxicity being one of the most limiting adverse events due to the dose and the worsening of the clinical condition of affected patients, triggering acute kidney injury in the vast majority of cases. . In this context, an integrative review was carried out, with the objective of evaluating the scientific literature on the nephrotoxicity of polymyxin B and the consequences caused to individuals who are affected by kidney damage after the use of the antibiotic. Scientific articles were selected from the PUBMED database, using “Polymyxin B AND nephrotoxicity” as descriptors and with a time span of 5 years. From the review, it was found that acute kidney injury induced by polymyxin B nephrotoxicity generates significant impact on adult or pediatric patients, such as longer hospitalization, long-term consequences and increased risk of mortality. Discontinuing the antimicrobial proved to be the most effective option to manage kidney damage, but, in fact, the best way to preserve the integrity of kidney function is to avoid toxic events through follow-up, strict assistance to individuals and not using concomitant polymyxin B to other nephrotoxic agents during this period. In pediatric patients, the incidence of nephrotoxicity is high and therefore treatment with polymyxin B should be an option in last cases with intense monitoring.A polimixina B faz parte de uma antiga classe de antimicrobianos utilizados para combater infecções originadas de bactérias gram-negativas multirresistentes. Apesar de ser uma ótima opção de tratamento, possui perfil citotóxico que acomete as células renais, sendo a nefrotoxicidade um dos eventos adversos mais limitantes em função da dose e do agravamento do quadro clínico de pacientes afetados, desencadeando lesão renal aguda na grande maioria dos casos. Nesse contexto, foi realizada uma revisão integrativa, com o objetivo de avaliar a literatura científica sobre a nefrotoxicidade da polimixina B e as consequências ocasionadas aos indivíduos que são acometidos pelo dano renal após o uso do antibiótico. Os artigos científicos foram selecionados na base de dados PUBMED, utilizando “Polymyxin B AND nephrotoxicity”, como descritores e com abrangência temporal de 5 anos. A partir da revisão, constatou-se que a lesão renal aguda induzida pela nefrotoxicidade da polimixina B gera impacto significativo nos pacientes adultos ou pediátricos, como maior tempo de hospitalização, consequências a longo prazo e maior risco de mortalidade. A suspensão do antimicrobiano demonstrou ser a opção mais eficaz para manejar dano renal, mas, de fato, a melhor forma de preservar a integridade da função renal é evitar eventos tóxicos por meio de acompanhamento, assistência rigorosa aos indivíduos e não utilização da polimixina B concomitante a outros agentes nefrotóxicos durante esse período. Em pacientes pediátricos, a incidência de nefrotoxicidade é alta e por isso o tratamento com polimixina B deve ser uma opção em últimos casos com monitoramento intenso.Universidade de Passo FundoInstituto de Ciências Biológicas - ICBBrasilUPFGrando, Luciana Grazziotin RossatoMezzomo, Regina2025-05-10T22:24:00Z2022-12-12info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisapplication/pdfMEZZOMO, Regina. A nefrotoxicidade da polimixina B. 2022. 28 f. Trabalho de Conclusão de Curso (Farmacêutico). Curso de Farmácia. Universidade de Passo Fundo, Passo Fundo, 2022.https://repositorio.upf.br/handle/123456789/7432porinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UPFinstname:Universidade de Passo Fundo (UPF)instacron:UPF2025-12-30T20:05:04Zoai:repositorio.upf.br:123456789/7432Repositório InstitucionalPRIhttp://repositorio.upf.br/oai/requestjucelei@upf.br||biblio@upf.bropendoar:16102025-12-30T20:05:04Repositório Institucional da UPF - Universidade de Passo Fundo (UPF) |
| spellingShingle | A nefrotoxicidade da polimixina B Mezzomo, Regina Farmácia Polimixina B Lesão renal Manejo Nefrotoxicidade |
| status_str | publishedVersion |
| title | A nefrotoxicidade da polimixina B |
| title_full | A nefrotoxicidade da polimixina B |
| title_fullStr | A nefrotoxicidade da polimixina B |
| title_full_unstemmed | A nefrotoxicidade da polimixina B |
| title_short | A nefrotoxicidade da polimixina B |
| title_sort | A nefrotoxicidade da polimixina B |
| topic | Farmácia Polimixina B Lesão renal Manejo Nefrotoxicidade |
| url | https://repositorio.upf.br/handle/123456789/7432 |