The scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 opening
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| Hovedforfatter: | |
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| Publication Date: | 2015 |
| Andre forfattere: | , , , |
| Format: | Article |
| Sprog: | eng |
| Source: | Repositório Institucional da UnB |
| Download full: | http://repositorio.unb.br/handle/10482/23891 https://dx.doi.org/10.1371/ journal.pone.0128578 |
Summary: | We identified Tf2, the first β-scorpion toxin from the venom of the Brazilian scorpion Tityus fasciolatus. Tf2 is identical to Tb2-II found in Tityus bahiensis.We found that Tf2 selectively activates human (h)Nav1.3, a neuronal voltage-gated sodium (Nav) subtype implicated in epilepsy and nociception. Tf2 shifts hNav1.3 activation voltage to more negative values, thereby opening the channel at resting membrane potentials. Seven other tested mammalian Nav channels (Nav1.1-1.2; Nav1.4-1.8) expressed in Xenopus oocytes are insensitive upon application of 1 μM Tf2. Therefore, the identification of Tf2 represents a unique addition to the repertoire of animal toxins that can be used to investigate Nav channel function. |
Lignende værker: The scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 opening
- Caracterização eletrofisiológica da toxina TF1a purificada da peçonha do escorpião Tityus fasciolatus
- Estrutura primária e atividade sobre canais KV e CaV do peptídeo TfTx, isolado da peçonha do escorpião Tityus fasciolatus
- Identification and phylogenetic analysis of Tityus pachyurus and Tityus obscurus novel Putative Na+-Channel scorpion toxins
- Identification and phylogenetic analysis of Tityus pachyurus and Tityus obscurus novel putative Na+-channel scorpion toxins
- Caracterização parcial de duas toxinas isoladas da peçonha do escorpião Tityus mattogrossensis (Borelli, 1901)
- Prospecção da peçonha do escorpião Tityus fasciolatus sob a perspectiva proteômica e transcritômica, e caracterização biológica de peptídeos moduladores de canais de Na+