Enterolobin induces rat paw oedema independently of PAF-Acether

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Hlavní autor:	Faria Neto, Hugo Caire de Castro
Datum vydání:	1991
Další autoři:	Cordeiro, Renato Sergio Balao, Martins, Marco Aurélio, Silva, A. C. V. Correira da, Bozza, Patricia Torres, Sousa, Marcelo Valle de, Morhy, Lauro
Médium:	Article
Jazyk:	eng
Zdroj:	Repositório Institucional da UnB
Download full:	http://repositorio.unb.br/handle/10482/9587
Shrnutí:	The potential participation of PAF-acether (PAF) on the paw oedema triggered by enterolobin was investigated. Intraplantar injections of enterolobin (5-20 µg/paw) yielded a dose response curve for oedema which appeared after 30 min, peaked in the interval between 2-4 h and faded after 24 h. The pre-treatment with BN 52021, but not with other PAF antagonists such as PCA 4248 or WEB 2086, significantly blocked enterolobin-induced oedema. To clarify better the discrepant results obtained with the PAF antagonists, desensitization to PAF was perfomed. The oedema triggered by enterolobin was not modified in PAF desensitized animals. It was concluded that the paw inflammation induced by enterolobin does not require PAF mechanism.

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Shrnutí:	The potential participation of PAF-acether (PAF) on the paw oedema triggered by enterolobin was investigated. Intraplantar injections of enterolobin (5-20 µg/paw) yielded a dose response curve for oedema which appeared after 30 min, peaked in the interval between 2-4 h and faded after 24 h. The pre-treatment with BN 52021, but not with other PAF antagonists such as PCA 4248 or WEB 2086, significantly blocked enterolobin-induced oedema. To clarify better the discrepant results obtained with the PAF antagonists, desensitization to PAF was perfomed. The oedema triggered by enterolobin was not modified in PAF desensitized animals. It was concluded that the paw inflammation induced by enterolobin does not require PAF mechanism.

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