Prevalence of celiac disease among first degree relatives of Brazilian celiac patients
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| Main Author: | |
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| Publication Date: | 2008 |
| Other Authors: | , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositório Institucional da UnB |
| Download full: | http://repositorio.unb.br/handle/10482/20680 http://dx.doi.org/10.1590/S0004-28032008000100013 |
Summary: | Background - Several studies have shown that celiac disease, an autoimmune disorder that occurs in genetically susceptible individuals, is highly prevalent among relatives of celiac patients. Aim - To determine the prevalence of celiac disease in a group of first degree relatives of Brazilian celiac patients. Methods - First degree relatives of celiac patients attending the Brasilia University Hospital Pediatric Gastroenterology Outpatient Clinic or the Celiac Disease Investigation Center, Brasília, DF, Brazil, between March 2001 and November 2004 were invited to undergo serological screening for celiac disease applying the IgA anti-endomysium antibody test (IgA-EMA). All positive IgA-EMA sera underwent a second screening using the IgA anti-tissue transglutaminase antibodies test. Duodenal or small intestinal biopsies were performed in all subjects positive to serological testing. Biopsy samples were classified as type (O) normal, (I) infiltrative, (II) infiltrative hyperplastic, (III) flat destructive, and (IV) atrophic hypoplastic. The final diagnosis was ascertained in subjects showing positive serological tests and a grade I to III small intestinal lesion. Results - Nine new cases of celiac disease were found among the 188 first degree relatives tested (4.8%). Conclusion - The present study confirms the high prevalence of celiac disease among first degree celiac patients’ relatives and reinforces the need of extensive diagnostic screening in this specific group. |
| _version_ | 1871442532352655360 |
|---|---|
| author | Almeida, Patrícia Lopes de |
| author2 | Gandolfi, Lenora Modelli, Inês Cristina Martins, Rita de Cássia Almeida, Rodrigo Coutinho de Pratesi, Riccardo |
| author2_role | author author author author author |
| author_browse | Almeida, Patrícia Lopes de Almeida, Rodrigo Coutinho de Gandolfi, Lenora Martins, Rita de Cássia Modelli, Inês Cristina Pratesi, Riccardo |
| author_facet | Almeida, Patrícia Lopes de Gandolfi, Lenora Modelli, Inês Cristina Martins, Rita de Cássia Almeida, Rodrigo Coutinho de Pratesi, Riccardo |
| author_role | author |
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| bitstream.url.fl_str_mv | http://repositorio.unb.br/bitstream/10482/20680/1/ARTIGO_PrevalenceCeliacDisease.pdf http://repositorio.unb.br/bitstream/10482/20680/2/license.txt |
| collection | Repositório Institucional da UnB |
| dc.contributor.author.fl_str_mv | Almeida, Patrícia Lopes de Gandolfi, Lenora Modelli, Inês Cristina Martins, Rita de Cássia Almeida, Rodrigo Coutinho de Pratesi, Riccardo |
| dc.date.accessioned.fl_str_mv | 2016-06-08T15:24:31Z |
| dc.date.available.fl_str_mv | 2016-06-08T15:24:31Z |
| dc.date.issued.fl_str_mv | 2008-01 |
| dc.identifier.citation.fl_str_mv | ALMEIDA, Patrícia Lopes de et al. Prevalence of celiac disease among first degree relatives of Brazilian celiac patients. Arquivos de Gastroenterologia, São Paulo, v. 45, n. 1, p. 69-72, Mar. 2008. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032008000100013&lng=en&nrm=iso>. Acesso em: 11 maio 2016. http://dx.doi.org/10.1590/S0004-28032008000100013. |
| dc.identifier.doi.en.fl_str_mv | http://dx.doi.org/10.1590/S0004-28032008000100013 |
| dc.identifier.uri.fl_str_mv | http://repositorio.unb.br/handle/10482/20680 |
| dc.language.iso.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE; Colégio Brasileiro de Cirurgia Digestiva - CBCD; Sociedade Brasileira de Motilidade Digestiva - SBMD; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED |
| dc.rights.driver.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
| dc.subject.keyword.en.fl_str_mv | Doença celíaca Genética |
| dc.title.en.fl_str_mv | Prevalence of celiac disease among first degree relatives of Brazilian celiac patients |
| dc.type.driver.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Background - Several studies have shown that celiac disease, an autoimmune disorder that occurs in genetically susceptible individuals, is highly prevalent among relatives of celiac patients. Aim - To determine the prevalence of celiac disease in a group of first degree relatives of Brazilian celiac patients. Methods - First degree relatives of celiac patients attending the Brasilia University Hospital Pediatric Gastroenterology Outpatient Clinic or the Celiac Disease Investigation Center, Brasília, DF, Brazil, between March 2001 and November 2004 were invited to undergo serological screening for celiac disease applying the IgA anti-endomysium antibody test (IgA-EMA). All positive IgA-EMA sera underwent a second screening using the IgA anti-tissue transglutaminase antibodies test. Duodenal or small intestinal biopsies were performed in all subjects positive to serological testing. Biopsy samples were classified as type (O) normal, (I) infiltrative, (II) infiltrative hyperplastic, (III) flat destructive, and (IV) atrophic hypoplastic. The final diagnosis was ascertained in subjects showing positive serological tests and a grade I to III small intestinal lesion. Results - Nine new cases of celiac disease were found among the 188 first degree relatives tested (4.8%). Conclusion - The present study confirms the high prevalence of celiac disease among first degree celiac patients’ relatives and reinforces the need of extensive diagnostic screening in this specific group. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | UNB_d2e7dde4053dcf5e6810ea08e3ef5e13 |
| identifier_str_mv | ALMEIDA, Patrícia Lopes de et al. Prevalence of celiac disease among first degree relatives of Brazilian celiac patients. Arquivos de Gastroenterologia, São Paulo, v. 45, n. 1, p. 69-72, Mar. 2008. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032008000100013&lng=en&nrm=iso>. Acesso em: 11 maio 2016. http://dx.doi.org/10.1590/S0004-28032008000100013. |
| instacron_str | UNB |
| institution | UNB |
| instname_str | Universidade de Brasília (UnB) |
| language | eng |
| network_acronym_str | UNB |
| network_name_str | Repositório Institucional da UnB |
| oai_identifier_str | oai:repositorio.unb.br:10482/20680 |
| publishDate | 2008 |
| publishDateSort | 2008 |
| publisher.none.fl_str_mv | Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE; Colégio Brasileiro de Cirurgia Digestiva - CBCD; Sociedade Brasileira de Motilidade Digestiva - SBMD; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED |
| reponame_str | Repositório Institucional da UnB |
| repository.mail.fl_str_mv | repositorio@unb.br |
| repository.name.fl_str_mv | Repositório Institucional da UnB - Universidade de Brasília (UnB) |
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| spelling | Almeida, Patrícia Lopes deGandolfi, LenoraModelli, Inês CristinaMartins, Rita de CássiaAlmeida, Rodrigo Coutinho dePratesi, Riccardo2016-06-08T15:24:31Z2016-06-08T15:24:31Z2008-01ALMEIDA, Patrícia Lopes de et al. Prevalence of celiac disease among first degree relatives of Brazilian celiac patients. Arquivos de Gastroenterologia, São Paulo, v. 45, n. 1, p. 69-72, Mar. 2008. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032008000100013&lng=en&nrm=iso>. Acesso em: 11 maio 2016. http://dx.doi.org/10.1590/S0004-28032008000100013.http://repositorio.unb.br/handle/10482/20680http://dx.doi.org/10.1590/S0004-28032008000100013Background - Several studies have shown that celiac disease, an autoimmune disorder that occurs in genetically susceptible individuals, is highly prevalent among relatives of celiac patients. Aim - To determine the prevalence of celiac disease in a group of first degree relatives of Brazilian celiac patients. Methods - First degree relatives of celiac patients attending the Brasilia University Hospital Pediatric Gastroenterology Outpatient Clinic or the Celiac Disease Investigation Center, Brasília, DF, Brazil, between March 2001 and November 2004 were invited to undergo serological screening for celiac disease applying the IgA anti-endomysium antibody test (IgA-EMA). All positive IgA-EMA sera underwent a second screening using the IgA anti-tissue transglutaminase antibodies test. Duodenal or small intestinal biopsies were performed in all subjects positive to serological testing. Biopsy samples were classified as type (O) normal, (I) infiltrative, (II) infiltrative hyperplastic, (III) flat destructive, and (IV) atrophic hypoplastic. The final diagnosis was ascertained in subjects showing positive serological tests and a grade I to III small intestinal lesion. Results - Nine new cases of celiac disease were found among the 188 first degree relatives tested (4.8%). Conclusion - The present study confirms the high prevalence of celiac disease among first degree celiac patients’ relatives and reinforces the need of extensive diagnostic screening in this specific group.Faculdade de Medicina (FM)Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE; Colégio Brasileiro de Cirurgia Digestiva - CBCD; Sociedade Brasileira de Motilidade Digestiva - SBMD; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBEDArquivos de Gastroenterologia - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons (Attribution Non-Commercial 4.0 International ( CC BY- NC 4.0)). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032008000100013. Acesso em: 11 maio 2016.info:eu-repo/semantics/openAccessPrevalence of celiac disease among first degree relatives of Brazilian celiac patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDoença celíacaGenéticaengreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNBORIGINALARTIGO_PrevalenceCeliacDisease.pdfARTIGO_PrevalenceCeliacDisease.pdfapplication/pdf330638http://repositorio.unb.br/bitstream/10482/20680/1/ARTIGO_PrevalenceCeliacDisease.pdf6c1fad0a05608900ae016f1cea70c484MD51open accessLICENSElicense.txtlicense.txttext/plain253http://repositorio.unb.br/bitstream/10482/20680/2/license.txtf0c908e623b89da7cfc3df37a4424cabMD52open access10482/206802025-01-15 14:41:47.406open accessoai:repositorio.unb.br:10482/20680TGljZW5zZSBncmFudGVkIGJ5IENhbWlsYSAgRHVhcnRlIChjYW1pbGFkaWFzQGJjZS51bmIuYnIpIG9uIDIwMTYtMDUtMTFUMjA6MzU6MDNaIChHTVQpOgoKU3VibWlzc8OjbyBlZmV0aXZhZGEgcG9yIGludGVncmFudGUgZGEgZXF1aXBlIGRvIFJlcG9zaXTDs3JpbyBJbnN0aXR1Y2lvbmFsIGRhIFVuQiBkZSBhY29yZG8gY29tIGxpY2Vuw6dhIGNvbmNlZGlkYSBwZWxvIGF1dG9yIGUvb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzLg==Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2025-01-15T17:41:47Repositório Institucional da UnB - Universidade de Brasília (UnB) |
| spellingShingle | Prevalence of celiac disease among first degree relatives of Brazilian celiac patients Almeida, Patrícia Lopes de Doença celíaca Genética |
| status_str | publishedVersion |
| title | Prevalence of celiac disease among first degree relatives of Brazilian celiac patients |
| title_full | Prevalence of celiac disease among first degree relatives of Brazilian celiac patients |
| title_fullStr | Prevalence of celiac disease among first degree relatives of Brazilian celiac patients |
| title_full_unstemmed | Prevalence of celiac disease among first degree relatives of Brazilian celiac patients |
| title_short | Prevalence of celiac disease among first degree relatives of Brazilian celiac patients |
| title_sort | Prevalence of celiac disease among first degree relatives of Brazilian celiac patients |
| topic | Doença celíaca Genética |
| url | http://repositorio.unb.br/handle/10482/20680 http://dx.doi.org/10.1590/S0004-28032008000100013 |