Decreased phagocytic function in neutrophils and monocytes from peripheral blood in periodontal disease
Bewaard in:
| Hoofdauteur: | |
|---|---|
| Publicatiedatum: | 2012 |
| Andere auteurs: | , , |
| Formaat: | Article |
| Taal: | eng |
| Bron: | Repositório Institucional da UnB |
| Download full: | http://repositorio.unb.br/handle/10482/14210 http://dx.doi.org/10.1590/S1678-77572012000500002 |
Samenvatting: | Phagocytosis by neutrophils and monocytes constitutes the main defense mechanism against bacterial challenges in periodontitis. Phagocytosis by neutrophils has already been evaluated, whereas phagocytic function of monocytes has hardly been addressed so far. Objectives: The aim of this study was to assess phagocytosis by neutrophils and monocytes in periodontitis. Material and Methods: The sample included 30 subjects with severe periodontitis and 27 control subjects without periodontal disease. The phagocytic index (PhI) was calculated as the mean number of adhered/ingested Saccharomyces cerevisiae per phagocytozing monocyte or neutrophil multiplied by the percentage of phagocytes involved in phagocytosis. Results: A significant reduction in phagocyte functions was observed in individuals with periodontitis. The median of PhI of neutrophils using nonsensitized S. cerevisiae was 3 for the control group, and 1.5 for the periodontitis group (p=0.01, Mann-Whitney test). The median of PhI of monocytes with non-sensitized S. cerevisiae was 26.13 for the control group, and 13.23 for the periodontitis group (p=0.03, Mann Whitney test). The median of PhI of monocytes assessed with sensitized S. cerevisiae was 97.92 for the control group and 60.1 for the periodontitis group (p=0.005, t-test). Conclusion: The data demonstrated a reduction in the function of phagocytes, suggesting a decrease in immune defenses in periodontitis. |
| _version_ | 1871442505912811520 |
|---|---|
| author | Carneiro, Valéria Martins Araújo |
| author2 | Bezerra, Ana Cristina Barreto Guimarães, Maria do Carmo Machado Muniz-Junqueira, Maria Imaculada |
| author2_role | author author author |
| author_browse | Bezerra, Ana Cristina Barreto Carneiro, Valéria Martins Araújo Guimarães, Maria do Carmo Machado Muniz-Junqueira, Maria Imaculada |
| author_facet | Carneiro, Valéria Martins Araújo Bezerra, Ana Cristina Barreto Guimarães, Maria do Carmo Machado Muniz-Junqueira, Maria Imaculada |
| author_role | author |
| bitstream.checksum.fl_str_mv | 17b1ccbeb7f8b00787b39ff5fc5d59d5 487bc20c656159508a4eb246575e3d84 |
| bitstream.checksumAlgorithm.fl_str_mv | MD5 MD5 |
| bitstream.url.fl_str_mv | http://repositorio2.unb.br/jspui/bitstream/10482/14210/1/ARTIGO_DecreasedPhagocyticFunction.pdf http://repositorio2.unb.br/jspui/bitstream/10482/14210/2/license.txt |
| collection | Repositório Institucional da UnB |
| dc.contributor.author.fl_str_mv | Carneiro, Valéria Martins Araújo Bezerra, Ana Cristina Barreto Guimarães, Maria do Carmo Machado Muniz-Junqueira, Maria Imaculada |
| dc.date.accessioned.fl_str_mv | 2013-09-26T18:18:55Z |
| dc.date.available.fl_str_mv | 2013-09-26T18:18:55Z |
| dc.date.issued.fl_str_mv | 2012-09 |
| dc.identifier.citation.fl_str_mv | CARNEIRO, Valéria Martins Araújo et al. Decreased phagocytic function in neutrophils and monocytes from peripheral blood in periodontal disease. Journal of Applied Oral Science, Bauru, v. 20, n. 5, p. 503-509, set./out. 2012. Disponível em: <http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1678-77572012000500002&lng=pt&nrm=iso&tlng=en>. Acesso em: 25 set. 2013. DOI: http://dx.doi.org/10.1590/S1678-77572012000500002. |
| dc.identifier.doi.en.fl_str_mv | http://dx.doi.org/10.1590/S1678-77572012000500002 |
| dc.identifier.uri.fl_str_mv | http://repositorio.unb.br/handle/10482/14210 |
| dc.language.iso.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Faculdade de Odontologia de Bauru - USP |
| dc.rights.driver.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
| dc.subject.keyword.en.fl_str_mv | Periodontite Doença periodontal Neutrófilos Fagocitose |
| dc.title.en.fl_str_mv | Decreased phagocytic function in neutrophils and monocytes from peripheral blood in periodontal disease |
| dc.type.driver.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Phagocytosis by neutrophils and monocytes constitutes the main defense mechanism against bacterial challenges in periodontitis. Phagocytosis by neutrophils has already been evaluated, whereas phagocytic function of monocytes has hardly been addressed so far. Objectives: The aim of this study was to assess phagocytosis by neutrophils and monocytes in periodontitis. Material and Methods: The sample included 30 subjects with severe periodontitis and 27 control subjects without periodontal disease. The phagocytic index (PhI) was calculated as the mean number of adhered/ingested Saccharomyces cerevisiae per phagocytozing monocyte or neutrophil multiplied by the percentage of phagocytes involved in phagocytosis. Results: A significant reduction in phagocyte functions was observed in individuals with periodontitis. The median of PhI of neutrophils using nonsensitized S. cerevisiae was 3 for the control group, and 1.5 for the periodontitis group (p=0.01, Mann-Whitney test). The median of PhI of monocytes with non-sensitized S. cerevisiae was 26.13 for the control group, and 13.23 for the periodontitis group (p=0.03, Mann Whitney test). The median of PhI of monocytes assessed with sensitized S. cerevisiae was 97.92 for the control group and 60.1 for the periodontitis group (p=0.005, t-test). Conclusion: The data demonstrated a reduction in the function of phagocytes, suggesting a decrease in immune defenses in periodontitis. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | UNB_cee2adf04bedacb6462dd4f7c98dffe4 |
| identifier_str_mv | CARNEIRO, Valéria Martins Araújo et al. Decreased phagocytic function in neutrophils and monocytes from peripheral blood in periodontal disease. Journal of Applied Oral Science, Bauru, v. 20, n. 5, p. 503-509, set./out. 2012. Disponível em: <http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1678-77572012000500002&lng=pt&nrm=iso&tlng=en>. Acesso em: 25 set. 2013. DOI: http://dx.doi.org/10.1590/S1678-77572012000500002. |
| instacron_str | UNB |
| institution | UNB |
| instname_str | Universidade de Brasília (UnB) |
| language | eng |
| network_acronym_str | UNB |
| network_name_str | Repositório Institucional da UnB |
| oai_identifier_str | oai:repositorio.unb.br:10482/14210 |
| publishDate | 2012 |
| publishDateSort | 2012 |
| publisher.none.fl_str_mv | Faculdade de Odontologia de Bauru - USP |
| reponame_str | Repositório Institucional da UnB |
| repository.mail.fl_str_mv | repositorio@unb.br |
| repository.name.fl_str_mv | Repositório Institucional da UnB - Universidade de Brasília (UnB) |
| repository_id_str | |
| spelling | Carneiro, Valéria Martins AraújoBezerra, Ana Cristina BarretoGuimarães, Maria do Carmo MachadoMuniz-Junqueira, Maria Imaculada2013-09-26T18:18:55Z2013-09-26T18:18:55Z2012-09CARNEIRO, Valéria Martins Araújo et al. Decreased phagocytic function in neutrophils and monocytes from peripheral blood in periodontal disease. Journal of Applied Oral Science, Bauru, v. 20, n. 5, p. 503-509, set./out. 2012. Disponível em: <http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1678-77572012000500002&lng=pt&nrm=iso&tlng=en>. Acesso em: 25 set. 2013. DOI: http://dx.doi.org/10.1590/S1678-77572012000500002.http://repositorio.unb.br/handle/10482/14210http://dx.doi.org/10.1590/S1678-77572012000500002Phagocytosis by neutrophils and monocytes constitutes the main defense mechanism against bacterial challenges in periodontitis. Phagocytosis by neutrophils has already been evaluated, whereas phagocytic function of monocytes has hardly been addressed so far. Objectives: The aim of this study was to assess phagocytosis by neutrophils and monocytes in periodontitis. Material and Methods: The sample included 30 subjects with severe periodontitis and 27 control subjects without periodontal disease. The phagocytic index (PhI) was calculated as the mean number of adhered/ingested Saccharomyces cerevisiae per phagocytozing monocyte or neutrophil multiplied by the percentage of phagocytes involved in phagocytosis. Results: A significant reduction in phagocyte functions was observed in individuals with periodontitis. The median of PhI of neutrophils using nonsensitized S. cerevisiae was 3 for the control group, and 1.5 for the periodontitis group (p=0.01, Mann-Whitney test). The median of PhI of monocytes with non-sensitized S. cerevisiae was 26.13 for the control group, and 13.23 for the periodontitis group (p=0.03, Mann Whitney test). The median of PhI of monocytes assessed with sensitized S. cerevisiae was 97.92 for the control group and 60.1 for the periodontitis group (p=0.005, t-test). Conclusion: The data demonstrated a reduction in the function of phagocytes, suggesting a decrease in immune defenses in periodontitis.Faculdade de Odontologia de Bauru - USPJournal of Applied Oral Science - Todo o conteúdo do periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons - Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0). Fonte: http://www.scielo.br/scielo.php?script=sci_serial&pid=1678-7757&lng=pt&nrm=iso. Acesso em: 25 set. 2013.info:eu-repo/semantics/openAccessDecreased phagocytic function in neutrophils and monocytes from peripheral blood in periodontal diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePeriodontiteDoença periodontalNeutrófilosFagocitoseengreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNBORIGINALARTIGO_DecreasedPhagocyticFunction.pdfARTIGO_DecreasedPhagocyticFunction.pdfapplication/pdf384730http://repositorio2.unb.br/jspui/bitstream/10482/14210/1/ARTIGO_DecreasedPhagocyticFunction.pdf17b1ccbeb7f8b00787b39ff5fc5d59d5MD51open accessLICENSElicense.txtlicense.txttext/plain262http://repositorio2.unb.br/jspui/bitstream/10482/14210/2/license.txt487bc20c656159508a4eb246575e3d84MD52open access10482/142102023-05-24 20:06:03.92open accessoai:repositorio.unb.br:10482/14210TGljZW5zZSBncmFudGVkIGJ5IExlYW5kcm8gU2lsdmEgQm9yZ2VzIChsZWFuZHJvYm9yZ2VzQGJjZS51bmIuYnIpIG9uIDIwMTMtMDktMjVUMTg6NTU6MjlaIChHTVQpOgoKU3VibWlzc8OjbyBlZmV0aXZhZGEgcG9yIGludGVncmFudGUgZGEgZXF1aXBlIGRvIFJlcG9zaXTDs3JpbyBJbnN0aXR1Y2lvbmFsIGRhIFVuQiBkZSBhY29yZG8gY29tIGxpY2Vuw6dhIGNvbmNlZGlkYSBwZWxvIGF1dG9yIGUvb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzLg==Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2023-05-24T23:06:03Repositório Institucional da UnB - Universidade de Brasília (UnB) |
| spellingShingle | Decreased phagocytic function in neutrophils and monocytes from peripheral blood in periodontal disease Carneiro, Valéria Martins Araújo Periodontite Doença periodontal Neutrófilos Fagocitose |
| status_str | publishedVersion |
| title | Decreased phagocytic function in neutrophils and monocytes from peripheral blood in periodontal disease |
| title_full | Decreased phagocytic function in neutrophils and monocytes from peripheral blood in periodontal disease |
| title_fullStr | Decreased phagocytic function in neutrophils and monocytes from peripheral blood in periodontal disease |
| title_full_unstemmed | Decreased phagocytic function in neutrophils and monocytes from peripheral blood in periodontal disease |
| title_short | Decreased phagocytic function in neutrophils and monocytes from peripheral blood in periodontal disease |
| title_sort | Decreased phagocytic function in neutrophils and monocytes from peripheral blood in periodontal disease |
| topic | Periodontite Doença periodontal Neutrófilos Fagocitose |
| url | http://repositorio.unb.br/handle/10482/14210 http://dx.doi.org/10.1590/S1678-77572012000500002 |