The effectiveness of topical dimethicone together with a one health approach for the control of tungiasis in the Sanumás communities, Yanomami territory, Amazon rainforest: a real-world study
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| Autore principale: | |
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| Data di pubblicazione: | 2023 |
| Altri autori: | , , , , , , , , , , |
| Natura: | Article |
| Lingua: | eng |
| Fonte: | Repositório Institucional da UnB |
| Download full: | http://repositorio.unb.br/handle/10482/48901 https://doi.org/10.3390/tropicalmed8110489 https://orcid.org/0000-0003-3434-2669 https://orcid.org/0000-0003-1989-7412 https://orcid.org/0000-0001-8594-0015 https://orcid.org/0000-0002-9532-4854 https://orcid.org/0000-0002-3069-6884 |
Riassunto: | Background: The success of tungiasis treatment is highly dependent on adequate environmental control. Methods: This is a real-world observational cohort study designed to monitor the effectiveness of topical dimethicone together with a One Health approach for the control of tungiasis in the Sanumás communities, Amazon rainforest, Brazil. We followed up on 562 indigenous people and 81 domestic dogs for 1.5 years in a 3-month interval. A new molecular method for large-scale soil evaluation was also tested. The control of tungiasis was independently conducted by the Brazilian Ministry of Health and comprised topical dimethicone application (NYDA®) for humans, single-dose oral afoxolaner for dogs, and in-house soil fumigation with fipronil. The main outcome was the occurrence of tungiasis after the use of topical dimethicone together with the One Health approach. Results: A total of 49 of the 562 indigenous people had active tungiasis at enrollment (8.72%). Only three cases of tungiasis resulted in active lesions after the use of topical dimethicone together with the One Health approach, with two cases of recurrence. From the 6-month follow-up and after, soil infestation was not detected. Conclusions: We conclude that the use of NYDA® together with animal and environmental interventions are effective measures for the control of tungiasis. |
| _version_ | 1871442501919834112 |
|---|---|
| author | Santana, Yago Ranniere Teixeira |
| author2 | Andrade, Débora Dornelas Belchior Costa Barroso, Daniel Holanda Silva, Andressa Vieira Oliveira, Lucas Felipe Carvalho Timbó, Renata Velôzo Araújo, David Dias Andrade, Rafael Rocha de Pellegrini, Marcos Antonio Carvalho, Fabíola Christian Almeida de Martins, Luciana Pereira Freire Gomes, Ciro Martins |
| author2_role | author author author author author author author author author author author |
| author_browse | Andrade, Débora Dornelas Belchior Costa Andrade, Rafael Rocha de Araújo, David Dias Barroso, Daniel Holanda Carvalho, Fabíola Christian Almeida de Gomes, Ciro Martins Martins, Luciana Pereira Freire Oliveira, Lucas Felipe Carvalho Pellegrini, Marcos Antonio Santana, Yago Ranniere Teixeira Silva, Andressa Vieira Timbó, Renata Velôzo |
| author_facet | Santana, Yago Ranniere Teixeira Andrade, Débora Dornelas Belchior Costa Barroso, Daniel Holanda Silva, Andressa Vieira Oliveira, Lucas Felipe Carvalho Timbó, Renata Velôzo Araújo, David Dias Andrade, Rafael Rocha de Pellegrini, Marcos Antonio Carvalho, Fabíola Christian Almeida de Martins, Luciana Pereira Freire Gomes, Ciro Martins |
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| bitstream.url.fl_str_mv | http://repositorio.unb.br/bitstream/10482/48901/1/ARTIGO_EffectivenessTopicalDimethicone.pdf http://repositorio.unb.br/bitstream/10482/48901/2/license.txt |
| collection | Repositório Institucional da UnB |
| dc.contributor.affiliation.pt_BR.fl_str_mv | Universidade de Brasília, Programa de Pós-Graduação em Ciências Médicas Ministério da Saúde do Brasil, Secretaria Especial de Saúde Indígena (SESAI) Universidade de Brasília, Programa de Pós-Graduação em Saúde Coletiva Universidade de Brasília, Programa de Pós-Graduação em Ciências Médicas Universidade de Brasília, Programa de Pós-Graduação em Ciências Médicas Universidade de Brasília, Programa de Pós-Graduação em Ciências Médicas Ministério da Saúde do Brasil, Secretaria Especial de Saúde Indígena (SESAI) Universidade de Brasília, Programa de Pós-Graduação em Ciências Médicas Dimensuri Assessoria Técnica, Brasília Universidade de Brasília, Programa de Pós-Graduação em Ciências Médicas Universidade Federal de Roraima, Programa de Pós-Graduação em Ciências da Saúde Universidade Federal de Roraima, Programa de Pós-Graduação em Ciências da Saúde Universidade de Brasília, Programa de Pós-Graduação em Patologia Molecular Universidade de Brasília, Programa de Pós-Graduação em Ciências Médicas Universidade de Brasília, Programa de Pós-Graduação em Patologia Molecular |
| dc.contributor.author.fl_str_mv | Santana, Yago Ranniere Teixeira Andrade, Débora Dornelas Belchior Costa Barroso, Daniel Holanda Silva, Andressa Vieira Oliveira, Lucas Felipe Carvalho Timbó, Renata Velôzo Araújo, David Dias Andrade, Rafael Rocha de Pellegrini, Marcos Antonio Carvalho, Fabíola Christian Almeida de Martins, Luciana Pereira Freire Gomes, Ciro Martins |
| dc.date.accessioned.fl_str_mv | 2024-07-16T15:51:53Z |
| dc.date.available.fl_str_mv | 2024-07-16T15:51:53Z |
| dc.date.issued.fl_str_mv | 2023-10-25 |
| dc.identifier.citation.fl_str_mv | SANTANA, Yago Ranniere Teixeira et al. The effectiveness of topical dimethicone together with a one health approach for the control of tungiasis in the Sanumás communities, Yanomami territory, Amazon rainforest: a real-world study. Tropical Medicine and Infections Diseases, [S. l.], v. 8, n. 11, 489, 2023. DOI: https://doi.org/10.3390/tropicalmed8110489. Disponível em: https://www.mdpi.com/2414-6366/8/11/489. Acesso em: 16 jul. 2024. |
| dc.identifier.doi.pt_BR.fl_str_mv | https://doi.org/10.3390/tropicalmed8110489 |
| dc.identifier.orcid.pt_BR.fl_str_mv | https://orcid.org/0000-0003-3434-2669 https://orcid.org/0000-0003-1989-7412 https://orcid.org/0000-0001-8594-0015 https://orcid.org/0000-0002-9532-4854 https://orcid.org/0000-0002-3069-6884 |
| dc.identifier.uri.fl_str_mv | http://repositorio.unb.br/handle/10482/48901 |
| dc.language.iso.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.rights.driver.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
| dc.subject.keyword.pt_BR.fl_str_mv | Tungíase Indígenas Doenças infecciosas |
| dc.title.pt_BR.fl_str_mv | The effectiveness of topical dimethicone together with a one health approach for the control of tungiasis in the Sanumás communities, Yanomami territory, Amazon rainforest: a real-world study |
| dc.type.driver.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Background: The success of tungiasis treatment is highly dependent on adequate environmental control. Methods: This is a real-world observational cohort study designed to monitor the effectiveness of topical dimethicone together with a One Health approach for the control of tungiasis in the Sanumás communities, Amazon rainforest, Brazil. We followed up on 562 indigenous people and 81 domestic dogs for 1.5 years in a 3-month interval. A new molecular method for large-scale soil evaluation was also tested. The control of tungiasis was independently conducted by the Brazilian Ministry of Health and comprised topical dimethicone application (NYDA®) for humans, single-dose oral afoxolaner for dogs, and in-house soil fumigation with fipronil. The main outcome was the occurrence of tungiasis after the use of topical dimethicone together with the One Health approach. Results: A total of 49 of the 562 indigenous people had active tungiasis at enrollment (8.72%). Only three cases of tungiasis resulted in active lesions after the use of topical dimethicone together with the One Health approach, with two cases of recurrence. From the 6-month follow-up and after, soil infestation was not detected. Conclusions: We conclude that the use of NYDA® together with animal and environmental interventions are effective measures for the control of tungiasis. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | UNB_cc7ef9dfd13053a16fdcedbd766a0cfc |
| identifier_str_mv | SANTANA, Yago Ranniere Teixeira et al. The effectiveness of topical dimethicone together with a one health approach for the control of tungiasis in the Sanumás communities, Yanomami territory, Amazon rainforest: a real-world study. Tropical Medicine and Infections Diseases, [S. l.], v. 8, n. 11, 489, 2023. DOI: https://doi.org/10.3390/tropicalmed8110489. Disponível em: https://www.mdpi.com/2414-6366/8/11/489. Acesso em: 16 jul. 2024. |
| instacron_str | UNB |
| institution | UNB |
| instname_str | Universidade de Brasília (UnB) |
| language | eng |
| network_acronym_str | UNB |
| network_name_str | Repositório Institucional da UnB |
| oai_identifier_str | oai:repositorio.unb.br:10482/48901 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| publisher.none.fl_str_mv | MDPI |
| reponame_str | Repositório Institucional da UnB |
| repository.mail.fl_str_mv | repositorio@unb.br |
| repository.name.fl_str_mv | Repositório Institucional da UnB - Universidade de Brasília (UnB) |
| repository_id_str | |
| spelling | Santana, Yago Ranniere TeixeiraAndrade, Débora Dornelas Belchior CostaBarroso, Daniel HolandaSilva, Andressa VieiraOliveira, Lucas Felipe CarvalhoTimbó, Renata VelôzoAraújo, David DiasAndrade, Rafael Rocha dePellegrini, Marcos AntonioCarvalho, Fabíola Christian Almeida deMartins, Luciana Pereira FreireGomes, Ciro MartinsUniversidade de Brasília, Programa de Pós-Graduação em Ciências MédicasMinistério da Saúde do Brasil, Secretaria Especial de Saúde Indígena (SESAI)Universidade de Brasília, Programa de Pós-Graduação em Saúde ColetivaUniversidade de Brasília, Programa de Pós-Graduação em Ciências MédicasUniversidade de Brasília, Programa de Pós-Graduação em Ciências MédicasUniversidade de Brasília, Programa de Pós-Graduação em Ciências MédicasMinistério da Saúde do Brasil, Secretaria Especial de Saúde Indígena (SESAI)Universidade de Brasília, Programa de Pós-Graduação em Ciências MédicasDimensuri Assessoria Técnica, BrasíliaUniversidade de Brasília, Programa de Pós-Graduação em Ciências MédicasUniversidade Federal de Roraima, Programa de Pós-Graduação em Ciências da SaúdeUniversidade Federal de Roraima, Programa de Pós-Graduação em Ciências da SaúdeUniversidade de Brasília, Programa de Pós-Graduação em Patologia MolecularUniversidade de Brasília, Programa de Pós-Graduação em Ciências MédicasUniversidade de Brasília, Programa de Pós-Graduação em Patologia Molecular2024-07-16T15:51:53Z2024-07-16T15:51:53Z2023-10-25SANTANA, Yago Ranniere Teixeira et al. The effectiveness of topical dimethicone together with a one health approach for the control of tungiasis in the Sanumás communities, Yanomami territory, Amazon rainforest: a real-world study. Tropical Medicine and Infections Diseases, [S. l.], v. 8, n. 11, 489, 2023. DOI: https://doi.org/10.3390/tropicalmed8110489. Disponível em: https://www.mdpi.com/2414-6366/8/11/489. Acesso em: 16 jul. 2024.http://repositorio.unb.br/handle/10482/48901https://doi.org/10.3390/tropicalmed8110489https://orcid.org/0000-0003-3434-2669https://orcid.org/0000-0003-1989-7412https://orcid.org/0000-0001-8594-0015https://orcid.org/0000-0002-9532-4854https://orcid.org/0000-0002-3069-6884engMDPICopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).info:eu-repo/semantics/openAccessThe effectiveness of topical dimethicone together with a one health approach for the control of tungiasis in the Sanumás communities, Yanomami territory, Amazon rainforest: a real-world studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleTungíaseIndígenasDoenças infecciosasBackground: The success of tungiasis treatment is highly dependent on adequate environmental control. Methods: This is a real-world observational cohort study designed to monitor the effectiveness of topical dimethicone together with a One Health approach for the control of tungiasis in the Sanumás communities, Amazon rainforest, Brazil. We followed up on 562 indigenous people and 81 domestic dogs for 1.5 years in a 3-month interval. A new molecular method for large-scale soil evaluation was also tested. The control of tungiasis was independently conducted by the Brazilian Ministry of Health and comprised topical dimethicone application (NYDA®) for humans, single-dose oral afoxolaner for dogs, and in-house soil fumigation with fipronil. The main outcome was the occurrence of tungiasis after the use of topical dimethicone together with the One Health approach. Results: A total of 49 of the 562 indigenous people had active tungiasis at enrollment (8.72%). Only three cases of tungiasis resulted in active lesions after the use of topical dimethicone together with the One Health approach, with two cases of recurrence. From the 6-month follow-up and after, soil infestation was not detected. Conclusions: We conclude that the use of NYDA® together with animal and environmental interventions are effective measures for the control of tungiasis.Faculdade de Medicina (FM)Faculdade de Ciências da Saúde (FS)Departamento de Saúde Coletiva (FS DSC)Instituto de Ciências Biológicas (IB)Departamento de Biologia Celular (IB CEL)Programa de Pós-Graduação em Ciências MédicasPrograma de Pós-Graduação em Saúde ColetivaPrograma de Pós-Graduação em Patologia Molecularreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNBORIGINALARTIGO_EffectivenessTopicalDimethicone.pdfARTIGO_EffectivenessTopicalDimethicone.pdfapplication/pdf4504031http://repositorio.unb.br/bitstream/10482/48901/1/ARTIGO_EffectivenessTopicalDimethicone.pdfb93ff549dc9bdfe9e1e169b2bbd60fa3MD51open accessLICENSElicense.txtlicense.txttext/plain102http://repositorio.unb.br/bitstream/10482/48901/2/license.txtaed4704d04bb260d4decd80db311aaa5MD52open access10482/489012025-02-27 14:00:24.878open accessoai:repositorio.unb.br:10482/48901U3VibWlzc8OjbyBlZmV0aXZhZGEgZGUgYWNvcmRvIGNvbSBsaWNlbsOnYSBjb25jZWRpZGEgcGVsbyBhdXRvciBlL291IGRldGVudG9yIGRvcyBkaXJlaXRvcyBhdXRvcmFpcy4KRepositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2025-02-27T17:00:24Repositório Institucional da UnB - Universidade de Brasília (UnB) |
| spellingShingle | The effectiveness of topical dimethicone together with a one health approach for the control of tungiasis in the Sanumás communities, Yanomami territory, Amazon rainforest: a real-world study Santana, Yago Ranniere Teixeira Tungíase Indígenas Doenças infecciosas |
| status_str | publishedVersion |
| title | The effectiveness of topical dimethicone together with a one health approach for the control of tungiasis in the Sanumás communities, Yanomami territory, Amazon rainforest: a real-world study |
| title_full | The effectiveness of topical dimethicone together with a one health approach for the control of tungiasis in the Sanumás communities, Yanomami territory, Amazon rainforest: a real-world study |
| title_fullStr | The effectiveness of topical dimethicone together with a one health approach for the control of tungiasis in the Sanumás communities, Yanomami territory, Amazon rainforest: a real-world study |
| title_full_unstemmed | The effectiveness of topical dimethicone together with a one health approach for the control of tungiasis in the Sanumás communities, Yanomami territory, Amazon rainforest: a real-world study |
| title_short | The effectiveness of topical dimethicone together with a one health approach for the control of tungiasis in the Sanumás communities, Yanomami territory, Amazon rainforest: a real-world study |
| title_sort | The effectiveness of topical dimethicone together with a one health approach for the control of tungiasis in the Sanumás communities, Yanomami territory, Amazon rainforest: a real-world study |
| topic | Tungíase Indígenas Doenças infecciosas |
| url | http://repositorio.unb.br/handle/10482/48901 https://doi.org/10.3390/tropicalmed8110489 https://orcid.org/0000-0003-3434-2669 https://orcid.org/0000-0003-1989-7412 https://orcid.org/0000-0001-8594-0015 https://orcid.org/0000-0002-9532-4854 https://orcid.org/0000-0002-3069-6884 |