Association of serum lipid components and obesity with genetic ancestry in an admixed population of elderly women
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Publikationsdatum: | 2012 |
| Weitere Verfasser: | , , , , , , |
| Format: | Article |
| Sprache: | eng |
| Quelle: | Repositório Institucional da UnB |
| Download full: | http://repositorio.unb.br/handle/10482/11704 http://dx.doi.org/10.1590/S1415-47572012005000047 |
Zusammenfassung: | The prevalence of metabolic disorders varies among ethnic populations and these disorders represent a critical health care issue for elderly women. This study investigated the correlation between genetic ancestry and body composition, metabolic traits and clinical status in a sample of elderly women. Clinical, nutritional and anthropometric data were collected from 176 volunteers. Genetic ancestry was estimated using 23 ancestry-informative markers. Pearsons correlation test was used to examine the relationship between continuous variables and an independent samples t-test was used to compare the means of continuous traits within categorical variables. Overall ancestry was a combination of European (57.49%), Native American (25.78%) and African (16.73%). Significant correlations were found for European ancestry with body mass index (r = 0.165; p = 0.037) and obesity (mean difference (MD) = 5.3%; p = 0.042). African ancestry showed a significant correlation with LDL (r = 0.159, p = 0.035), VLDL (r = -0.185; p = 0.014), hypertriglyceridemia (MD = 6.4%; p = 0.003) and hyperlipidemia (MD = 4.8%; p = 0.026). Amerindian ancestry showed a significant correlation with triglyceride levels (r = 0.150; p = 0.047) and hypertriglyceridemia (MD = 4.5%; p = 0.039). These findings suggest that genetic admixture may influence the etiology of lipid metabolism-related diseases and obesity in elderly women. |
Ähnliche Einträge: Association of serum lipid components and obesity with genetic ancestry in an admixed population of elderly women
- New insights for statistical analysis of blood pressure response to resistance training in elderly hypertensive women
- The higher exercise intensity and the presence of allele I of ACE gene elicit a higher post-exercise blood pressure reduction and nitric oxide release in elderly women : an experimental study
- Acute exercise performed close to the anaerobic threshold improves cognitive performance in elderly females
- Uso e circulação de medicamentos em um bairro popular urbano na Ceilândia, DF
- Violência e saúde mental de mulheres idosas : uma síntese da literatura
- Evaluation of waist circumference to predict general obesity and arterial hypertension in women in Greater Metropolitan Belo Horizonte, Brazil