Transcriptional profiles of the human pathogenic fungus paracoccidioides brasiliensis in mycelium and yeast cells
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| Autore principale: | |
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| Data di pubblicazione: | 2005 |
| Altri autori: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Natura: | Article |
| Lingua: | eng |
| Fonte: | Repositório Institucional da UnB |
| Download full: | http://repositorio.unb.br/handle/10482/12393 |
Riassunto: | This work was supported by MCT, CNPq, CAPES, FUB, UFG, and FUNDECT-MS. PbGenome Network: Alda Maria T. Ferreira, Alessandra Dantas, Alessandra J. Baptista, Alexandre M. Bailão, Ana Lídia Bonato, André C. Amaral, Bruno S. Daher, Camila M. Silva, Christiane S. Costa, Clayton L. Borges, Cléber O. Soares, Cristina M. Junta, Daniel A. S. Anjos, Edans F. O. Sandes, Eduardo A. Donadi, Elza T. Sakamoto-Hojo, Flábio R. Araújo, Flávia C. Albuquerque, Gina C. Oliveira, João Ricardo M. Almeida, Juliana C. Oliveira, Kláudia G. Jorge, Larissa Fernandes, Lorena S. Derengowski, Luís Artur M. Bataus, Marcus A. M. Araújo, Marcus K. Inoue, Marlene T. De-Souza, Mauro F. Almeida, Nádia S. Parachin, Nadya S. Castro, Odair P. Martins, Patrícia L. N. Costa, Paula Sandrin-Garcia, Renata B. A. Soares, Stephano S. Mello, and Viviane C. B. Reis |
| _version_ | 1871442453712601088 |
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| author | Felipe, Maria Sueli Soares |
| author2 | Andrade, Rosângela Vieira de Arraes, Fabrício Barbosa Monteiro Nicola, André Moraes Maranhão, Andréa Queiroz Torres, Fernando Araripe Gonçalves Pereira, Ildinete Silva Fonseca, Márcio José Poças Campos, Élida Geralda Moraes, Lídia Maria Pepe de Andrade, Patrícia Albuquerque de Tavares, Aldo Henrique Fonseca Pacheco Silva, Simoneide Souza Kyaw, Cynthia Maria Souza, Diorge Paulo PbGenome Network Pereira, Maristela Jesuíno, Rosália Santos Amorim Andrade, Edmar Vaz de Parente, Juliana Alves Oliveira, Gisele Silva de Barbosa, Mônica Santiago Martins, Natália Florêncio Fachin, Ana Lúcia Cardoso, Renato Sousa Passos Júnior, Geraldo Aleixo da Silva Almeida Júnior, Nalvo Franco de Walter, Maria Emília Machado Telles Soares, Célia Maria de Almeida Carvalho, Maria José Albuquerque de Brígido, Marcelo de Macedo |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| author_browse | Almeida Júnior, Nalvo Franco de Andrade, Edmar Vaz de Andrade, Patrícia Albuquerque de Andrade, Rosângela Vieira de Arraes, Fabrício Barbosa Monteiro Barbosa, Mônica Santiago Brígido, Marcelo de Macedo Campos, Élida Geralda Cardoso, Renato Sousa Carvalho, Maria José Albuquerque de Fachin, Ana Lúcia Felipe, Maria Sueli Soares Fonseca, Márcio José Poças Jesuíno, Rosália Santos Amorim Kyaw, Cynthia Maria Maranhão, Andréa Queiroz Martins, Natália Florêncio Moraes, Lídia Maria Pepe de Nicola, André Moraes Oliveira, Gisele Silva de Parente, Juliana Alves Passos Júnior, Geraldo Aleixo da Silva PbGenome Network Pereira, Ildinete Silva Pereira, Maristela Silva, Simoneide Souza Soares, Célia Maria de Almeida Souza, Diorge Paulo Tavares, Aldo Henrique Fonseca Pacheco Torres, Fernando Araripe Gonçalves Walter, Maria Emília Machado Telles |
| author_facet | Felipe, Maria Sueli Soares Andrade, Rosângela Vieira de Arraes, Fabrício Barbosa Monteiro Nicola, André Moraes Maranhão, Andréa Queiroz Torres, Fernando Araripe Gonçalves Pereira, Ildinete Silva Fonseca, Márcio José Poças Campos, Élida Geralda Moraes, Lídia Maria Pepe de Andrade, Patrícia Albuquerque de Tavares, Aldo Henrique Fonseca Pacheco Silva, Simoneide Souza Kyaw, Cynthia Maria Souza, Diorge Paulo PbGenome Network Pereira, Maristela Jesuíno, Rosália Santos Amorim Andrade, Edmar Vaz de Parente, Juliana Alves Oliveira, Gisele Silva de Barbosa, Mônica Santiago Martins, Natália Florêncio Fachin, Ana Lúcia Cardoso, Renato Sousa Passos Júnior, Geraldo Aleixo da Silva Almeida Júnior, Nalvo Franco de Walter, Maria Emília Machado Telles Soares, Célia Maria de Almeida Carvalho, Maria José Albuquerque de Brígido, Marcelo de Macedo |
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| collection | Repositório Institucional da UnB |
| dc.contributor.author.fl_str_mv | Felipe, Maria Sueli Soares Andrade, Rosângela Vieira de Arraes, Fabrício Barbosa Monteiro Nicola, André Moraes Maranhão, Andréa Queiroz Torres, Fernando Araripe Gonçalves Pereira, Ildinete Silva Fonseca, Márcio José Poças Campos, Élida Geralda Moraes, Lídia Maria Pepe de Andrade, Patrícia Albuquerque de Tavares, Aldo Henrique Fonseca Pacheco Silva, Simoneide Souza Kyaw, Cynthia Maria Souza, Diorge Paulo PbGenome Network Pereira, Maristela Jesuíno, Rosália Santos Amorim Andrade, Edmar Vaz de Parente, Juliana Alves Oliveira, Gisele Silva de Barbosa, Mônica Santiago Martins, Natália Florêncio Fachin, Ana Lúcia Cardoso, Renato Sousa Passos Júnior, Geraldo Aleixo da Silva Almeida Júnior, Nalvo Franco de Walter, Maria Emília Machado Telles Soares, Célia Maria de Almeida Carvalho, Maria José Albuquerque de Brígido, Marcelo de Macedo |
| dc.date.accessioned.fl_str_mv | 2013-03-07T12:10:38Z |
| dc.date.available.fl_str_mv | 2013-03-07T12:10:38Z |
| dc.date.issued.fl_str_mv | 2005-07 |
| dc.identifier.citation.fl_str_mv | FELIPE, Maria Sueli Soares et al. Transcriptional profiles of the human pathogenic fungus paracoccidioides brasiliensis in mycelium and yeast cells. The Journal Of Biological Chemistry, Rockville, v. 280, n. 26, Issue of July 1, p. 24706–24714, 2005. Disponível em: <http://www.jbc.org/content/280/26/24706.full.pdf>. Acesso em: 07 mar. 2013. DOI 10.1074/jbc.M500625200 |
| dc.identifier.doi.en.fl_str_mv | DOI https://dx.doi.org/10.1074/jbc.M500625200 |
| dc.identifier.uri.fl_str_mv | http://repositorio.unb.br/handle/10482/12393 |
| dc.language.iso.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Sociedade Americana de Bioquímica e Biologia Molecular |
| dc.rights.driver.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
| dc.subject.keyword.en.fl_str_mv | Paracoccidioides brasiliensis Fungos patogênicos Micologia |
| dc.title.en.fl_str_mv | Transcriptional profiles of the human pathogenic fungus paracoccidioides brasiliensis in mycelium and yeast cells |
| dc.type.driver.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | This work was supported by MCT, CNPq, CAPES, FUB, UFG, and FUNDECT-MS. PbGenome Network: Alda Maria T. Ferreira, Alessandra Dantas, Alessandra J. Baptista, Alexandre M. Bailão, Ana Lídia Bonato, André C. Amaral, Bruno S. Daher, Camila M. Silva, Christiane S. Costa, Clayton L. Borges, Cléber O. Soares, Cristina M. Junta, Daniel A. S. Anjos, Edans F. O. Sandes, Eduardo A. Donadi, Elza T. Sakamoto-Hojo, Flábio R. Araújo, Flávia C. Albuquerque, Gina C. Oliveira, João Ricardo M. Almeida, Juliana C. Oliveira, Kláudia G. Jorge, Larissa Fernandes, Lorena S. Derengowski, Luís Artur M. Bataus, Marcus A. M. Araújo, Marcus K. Inoue, Marlene T. De-Souza, Mauro F. Almeida, Nádia S. Parachin, Nadya S. Castro, Odair P. Martins, Patrícia L. N. Costa, Paula Sandrin-Garcia, Renata B. A. Soares, Stephano S. Mello, and Viviane C. B. Reis |
| eu_rights_str_mv | openAccess |
| format | article |
| id | UNB_adc1fdef6d90ebd11d3b3ca916dfd955 |
| identifier_str_mv | FELIPE, Maria Sueli Soares et al. Transcriptional profiles of the human pathogenic fungus paracoccidioides brasiliensis in mycelium and yeast cells. The Journal Of Biological Chemistry, Rockville, v. 280, n. 26, Issue of July 1, p. 24706–24714, 2005. Disponível em: <http://www.jbc.org/content/280/26/24706.full.pdf>. Acesso em: 07 mar. 2013. DOI 10.1074/jbc.M500625200 DOI https://dx.doi.org/10.1074/jbc.M500625200 |
| instacron_str | UNB |
| institution | UNB |
| instname_str | Universidade de Brasília (UnB) |
| language | eng |
| network_acronym_str | UNB |
| network_name_str | Repositório Institucional da UnB |
| oai_identifier_str | oai:repositorio.unb.br:10482/12393 |
| publishDate | 2005 |
| publishDateSort | 2005 |
| publisher.none.fl_str_mv | Sociedade Americana de Bioquímica e Biologia Molecular |
| reponame_str | Repositório Institucional da UnB |
| repository.mail.fl_str_mv | repositorio@unb.br |
| repository.name.fl_str_mv | Repositório Institucional da UnB - Universidade de Brasília (UnB) |
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| spelling | Felipe, Maria Sueli SoaresAndrade, Rosângela Vieira deArraes, Fabrício Barbosa MonteiroNicola, André MoraesMaranhão, Andréa QueirozTorres, Fernando Araripe GonçalvesPereira, Ildinete SilvaFonseca, Márcio José PoçasCampos, Élida GeraldaMoraes, Lídia Maria Pepe deAndrade, Patrícia Albuquerque deTavares, Aldo Henrique Fonseca PachecoSilva, Simoneide SouzaKyaw, Cynthia MariaSouza, Diorge PauloPbGenome NetworkPereira, MaristelaJesuíno, Rosália Santos AmorimAndrade, Edmar Vaz deParente, Juliana AlvesOliveira, Gisele Silva deBarbosa, Mônica SantiagoMartins, Natália FlorêncioFachin, Ana LúciaCardoso, Renato SousaPassos Júnior, Geraldo Aleixo da SilvaAlmeida Júnior, Nalvo Franco deWalter, Maria Emília Machado TellesSoares, Célia Maria de AlmeidaCarvalho, Maria José Albuquerque deBrígido, Marcelo de Macedo2013-03-07T12:10:38Z2013-03-07T12:10:38Z2005-07FELIPE, Maria Sueli Soares et al. Transcriptional profiles of the human pathogenic fungus paracoccidioides brasiliensis in mycelium and yeast cells. The Journal Of Biological Chemistry, Rockville, v. 280, n. 26, Issue of July 1, p. 24706–24714, 2005. Disponível em: <http://www.jbc.org/content/280/26/24706.full.pdf>. Acesso em: 07 mar. 2013. DOI 10.1074/jbc.M500625200http://repositorio.unb.br/handle/10482/12393DOI https://dx.doi.org/10.1074/jbc.M500625200This work was supported by MCT, CNPq, CAPES, FUB, UFG, and FUNDECT-MS. PbGenome Network: Alda Maria T. Ferreira, Alessandra Dantas, Alessandra J. Baptista, Alexandre M. Bailão, Ana Lídia Bonato, André C. Amaral, Bruno S. Daher, Camila M. Silva, Christiane S. Costa, Clayton L. Borges, Cléber O. Soares, Cristina M. Junta, Daniel A. S. Anjos, Edans F. O. Sandes, Eduardo A. Donadi, Elza T. Sakamoto-Hojo, Flábio R. Araújo, Flávia C. Albuquerque, Gina C. Oliveira, João Ricardo M. Almeida, Juliana C. Oliveira, Kláudia G. Jorge, Larissa Fernandes, Lorena S. Derengowski, Luís Artur M. Bataus, Marcus A. M. Araújo, Marcus K. Inoue, Marlene T. De-Souza, Mauro F. Almeida, Nádia S. Parachin, Nadya S. Castro, Odair P. Martins, Patrícia L. N. Costa, Paula Sandrin-Garcia, Renata B. A. Soares, Stephano S. Mello, and Viviane C. B. ReisParacoccidioides brasiliensis is the causative agent of paracoccidioidomycosis, a disease that affects 10 million individuals in Latin America. This report depicts the results of the analysis of 6,022 assembled groups from mycelium and yeast phase expressed sequence tags, covering about 80% of the estimated genome of this dimorphic, thermo-regulated fungus. The data provide a comprehensive view of the fungal metabolism, including overexpressed transcripts, stage-specific genes, and also those that are up- or down-regulated as assessed by in silico electronic subtraction and cDNA microarrays. Also, a significant differential expression pattern in mycelium and yeast cells was detected, which was confirmed by Northern blot analysis, providing insights into differential metabolic adaptations. The overall transcriptome analysis provided information about sequences related to the cell cycle, stress response, drug resistance, and signal transduction pathways of the pathogen. Novel P. brasiliensis genes have been identified, probably corresponding to proteins that should be addressed as virulence factor candidates and potential new drug targets.Sociedade Americana de Bioquímica e Biologia MolecularPermitido copiar, distribuir, transmitir e adaptar a obra - sem nenhum custo e sem permissão - para uso não comercial, desde que citada a fonte original. "This research was originally published in The Journal of Biological Chemistry. Maria Sueli S. Felipe, Rosângela V. Andrade, Fabrício B. M. Arraes, André M. Nicola, Andrea Q. Maranhão, Fernando A. G. Torres, Ildinete Silva-Pereira, Márcio J. Poças-Fonseca, Élida G. Campos,a Lídia M. P. Moraes,a Patrícia A. Andrade,Aldo H. F. P. Tavares, Simoneide S. Silva, Cynthia M. Kyaw,a Diorge P. Souza,PbGenome Network, Maristela Pereira,a Rosália S. A. Jesuíno, Edmar V. Andrade,Juliana A. Parente, Gisele S. Oliveira, Mônica S. Barbosa, Natália F. Martins, Ana L. Fachin, Renato S. Cardoso, Geraldo A. S. Passos, Nalvo F. Almeida, Maria Emília M. T. Walter,Célia M. A. Soares,Maria José A. Carvalho and Marcelo M. Brígido. Transcriptional Profiles of the Human Pathogenic Fungus Paracoccidioides brasiliensis in Mycelium and Yeast Cells. The Journal of Biological Chemistry. 2005, Vol. 280, No. 26, Issue of July 1, pp. 24706–24714. © Sociedade Americana de Bioquímica e Biologia Molecular." Fonte: http://www.jbc.org/site/misc/Copyright_Permission.xhtml. Acesso em: 07 mar. 2013.info:eu-repo/semantics/openAccessTranscriptional profiles of the human pathogenic fungus paracoccidioides brasiliensis in mycelium and yeast cellsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleParacoccidioides brasiliensisFungos patogênicosMicologiaengreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNBORIGINALARTIGO_TranscriptionalProfilesHuman.pdfARTIGO_TranscriptionalProfilesHuman.pdfapplication/pdf431661http://repositorio2.unb.br/jspui/bitstream/10482/12393/1/ARTIGO_TranscriptionalProfilesHuman.pdfc3a6c0186ca989625fa4298746bdef09MD51open accessLICENSElicense.txtlicense.txttext/plain267http://repositorio2.unb.br/jspui/bitstream/10482/12393/2/license.txt1c62b754a363d6c39f6f8935039c229eMD52open accessTEXTARTIGO_TranscriptionalProfilesHuman.pdf.txtARTIGO_TranscriptionalProfilesHuman.pdf.txtExtracted texttext/plain55820http://repositorio2.unb.br/jspui/bitstream/10482/12393/3/ARTIGO_TranscriptionalProfilesHuman.pdf.txtf50259693e8f530c419349a20b994782MD53open access10482/123932023-12-11 10:02:38.007open accessoai:repositorio.unb.br:10482/12393TGljZW5zZSBncmFudGVkIGJ5IEphcXVlbGluZSBGZXJyZWlyYSBkZSBTb3V6YSAoamFxdWVmcy5icmF6QGdtYWlsLmNvbSkgb24gMjAxMy0wMy0wN1QxMjowNjo1M1ogKEdNVCk6CgpTdWJtaXNzw6NvIGVmZXRpdmFkYSBwb3IgaW50ZWdyYW50ZSBkYSBlcXVpcGUgZG8gUmVwb3NpdMOzcmlvIEluc3RpdHVjaW9uYWwgZGEgVW5CIGRlIGFjb3JkbyBjb20gbGljZW7Dp2EgY29uY2VkaWRhIHBlbG8gYXV0b3IgZS9vdSBkZXRlbnRvciBkb3MgZGlyZWl0b3MgYXV0b3JhaXMuRepositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2023-12-11T13:02:38Repositório Institucional da UnB - Universidade de Brasília (UnB) |
| spellingShingle | Transcriptional profiles of the human pathogenic fungus paracoccidioides brasiliensis in mycelium and yeast cells Felipe, Maria Sueli Soares Paracoccidioides brasiliensis Fungos patogênicos Micologia |
| status_str | publishedVersion |
| title | Transcriptional profiles of the human pathogenic fungus paracoccidioides brasiliensis in mycelium and yeast cells |
| title_full | Transcriptional profiles of the human pathogenic fungus paracoccidioides brasiliensis in mycelium and yeast cells |
| title_fullStr | Transcriptional profiles of the human pathogenic fungus paracoccidioides brasiliensis in mycelium and yeast cells |
| title_full_unstemmed | Transcriptional profiles of the human pathogenic fungus paracoccidioides brasiliensis in mycelium and yeast cells |
| title_short | Transcriptional profiles of the human pathogenic fungus paracoccidioides brasiliensis in mycelium and yeast cells |
| title_sort | Transcriptional profiles of the human pathogenic fungus paracoccidioides brasiliensis in mycelium and yeast cells |
| topic | Paracoccidioides brasiliensis Fungos patogênicos Micologia |
| url | http://repositorio.unb.br/handle/10482/12393 |