Differences between Belgian and Brazilian group A Streptococcus epidemiologic landscape
Wedi'i Gadw mewn:
| Prif Awdur: | |
|---|---|
| Dyddiad Cyhoeddi: | 2006 |
| Awduron Eraill: | , , , , |
| Fformat: | Article |
| Iaith: | eng |
| Ffynhonnell: | Repositório Institucional da UnB |
| Download full: | http://repositorio.unb.br/handle/10482/23566 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000010 |
Crynodeb: | Background. Group A Streptococcus (GAS) clinical and molecular epidemiology varies with location and time. These differences are not or are poorly understood. Methods and Findings. We prospectively studied the epidemiology of GAS infections among children in outpatient hospital clinics in Brussels (Belgium) and Brası´lia (Brazil). Clinical questionnaires were filled out and microbiological sampling was performed. GAS isolates were emm-typed according to the Center for Disease Control protocol. emm pattern was predicted for each isolate. 334 GAS isolates were recovered from 706 children. Skin infections were frequent in Brası´lia (48% of the GAS infections), whereas pharyngitis were predominant (88%) in Brussels. The mean age of children with GAS pharyngitis in Brussels was lower than in Brası´lia (65/92 months, p,0.001). emm-typing revealed striking differences between Brazilian and Belgian GAS isolates. While 20 distinct emm-types were identified among 200 Belgian isolates, 48 were found among 128 Brazilian isolates. Belgian isolates belong mainly to emm pattern A–C (55%) and E (42.5%) while emm pattern E (51.5%) and D (36%) were predominant in Brası´lia. In Brası´lia, emm pattern D isolates were recovered from 18.5% of the pharyngitis, although this emm pattern is supposed to have a skin tropism. By contrast, A–C pattern isolates were unfrequently recovered in a region where rheumatic fever is still highly prevalent. Conclusions. Epidemiologic features of GAS from a pediatric population were very different in an industrialised country and a low incomes region, not only in term of clinical presentation, but also in terms of genetic diversity and distribution of emm patterns. These differences should be taken into account for designing treatment guidelines and vaccine strategies. |
| _version_ | 1871442441857400832 |
|---|---|
| author | Smeesters, Pierre Robert |
| author2 | Vergison, Anne Campos Júnior, Dioclécio Aguiar, Eurico de Deyi, Veronique Yvette Miendje Melderen, Laurence Van |
| author2_role | author author author author author |
| author_browse | Aguiar, Eurico de Campos Júnior, Dioclécio Deyi, Veronique Yvette Miendje Melderen, Laurence Van Smeesters, Pierre Robert Vergison, Anne |
| author_facet | Smeesters, Pierre Robert Vergison, Anne Campos Júnior, Dioclécio Aguiar, Eurico de Deyi, Veronique Yvette Miendje Melderen, Laurence Van |
| author_role | author |
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| bitstream.url.fl_str_mv | http://repositorio.unb.br/bitstream/10482/23566/1/ARTIGO_DifferencesBelgianBrazilian.PDF http://repositorio.unb.br/bitstream/10482/23566/2/license.txt |
| collection | Repositório Institucional da UnB |
| dc.contributor.author.fl_str_mv | Smeesters, Pierre Robert Vergison, Anne Campos Júnior, Dioclécio Aguiar, Eurico de Deyi, Veronique Yvette Miendje Melderen, Laurence Van |
| dc.date.accessioned.fl_str_mv | 2017-05-25T14:10:29Z |
| dc.date.available.fl_str_mv | 2017-05-25T14:10:29Z |
| dc.date.issued.fl_str_mv | 2006-12 |
| dc.identifier.citation.fl_str_mv | SMEESTERS, Pierre Robert et al. Differences between Belgian and Brazilian group A Streptococcus epidemiologic landscape. Plos One, v. 1, n. 1, e10. Disponível em: <http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000010>. Acesso em: 25 maio 2017. doi:10.1371/journal.pone.000001. |
| dc.identifier.doi.pt_BR.fl_str_mv | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000010 |
| dc.identifier.uri.fl_str_mv | http://repositorio.unb.br/handle/10482/23566 |
| dc.language.iso.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Plos One |
| dc.rights.driver.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
| dc.subject.keyword.pt_BR.fl_str_mv | Streptococcus - epidemiologia - Brasil - Bélgica |
| dc.title.pt_BR.fl_str_mv | Differences between Belgian and Brazilian group A Streptococcus epidemiologic landscape |
| dc.type.driver.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Background. Group A Streptococcus (GAS) clinical and molecular epidemiology varies with location and time. These differences are not or are poorly understood. Methods and Findings. We prospectively studied the epidemiology of GAS infections among children in outpatient hospital clinics in Brussels (Belgium) and Brası´lia (Brazil). Clinical questionnaires were filled out and microbiological sampling was performed. GAS isolates were emm-typed according to the Center for Disease Control protocol. emm pattern was predicted for each isolate. 334 GAS isolates were recovered from 706 children. Skin infections were frequent in Brası´lia (48% of the GAS infections), whereas pharyngitis were predominant (88%) in Brussels. The mean age of children with GAS pharyngitis in Brussels was lower than in Brası´lia (65/92 months, p,0.001). emm-typing revealed striking differences between Brazilian and Belgian GAS isolates. While 20 distinct emm-types were identified among 200 Belgian isolates, 48 were found among 128 Brazilian isolates. Belgian isolates belong mainly to emm pattern A–C (55%) and E (42.5%) while emm pattern E (51.5%) and D (36%) were predominant in Brası´lia. In Brası´lia, emm pattern D isolates were recovered from 18.5% of the pharyngitis, although this emm pattern is supposed to have a skin tropism. By contrast, A–C pattern isolates were unfrequently recovered in a region where rheumatic fever is still highly prevalent. Conclusions. Epidemiologic features of GAS from a pediatric population were very different in an industrialised country and a low incomes region, not only in term of clinical presentation, but also in terms of genetic diversity and distribution of emm patterns. These differences should be taken into account for designing treatment guidelines and vaccine strategies. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | UNB_a744dd5a1581c2a2d3695e787ae2affc |
| identifier_str_mv | SMEESTERS, Pierre Robert et al. Differences between Belgian and Brazilian group A Streptococcus epidemiologic landscape. Plos One, v. 1, n. 1, e10. Disponível em: <http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000010>. Acesso em: 25 maio 2017. doi:10.1371/journal.pone.000001. |
| instacron_str | UNB |
| institution | UNB |
| instname_str | Universidade de Brasília (UnB) |
| language | eng |
| network_acronym_str | UNB |
| network_name_str | Repositório Institucional da UnB |
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| publishDate | 2006 |
| publishDateSort | 2006 |
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| repository.name.fl_str_mv | Repositório Institucional da UnB - Universidade de Brasília (UnB) |
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| spelling | Smeesters, Pierre RobertVergison, AnneCampos Júnior, DioclécioAguiar, Eurico deDeyi, Veronique Yvette MiendjeMelderen, Laurence Van2017-05-25T14:10:29Z2017-05-25T14:10:29Z2006-12SMEESTERS, Pierre Robert et al. Differences between Belgian and Brazilian group A Streptococcus epidemiologic landscape. Plos One, v. 1, n. 1, e10. Disponível em: <http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000010>. Acesso em: 25 maio 2017. doi:10.1371/journal.pone.000001.http://repositorio.unb.br/handle/10482/23566http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000010Plos One© 2006 Smeesters et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Fonte: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000010. Acesso em: 25 maio 2017.info:eu-repo/semantics/openAccessDifferences between Belgian and Brazilian group A Streptococcus epidemiologic landscapeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleStreptococcus - epidemiologia - Brasil - BélgicaBackground. Group A Streptococcus (GAS) clinical and molecular epidemiology varies with location and time. These differences are not or are poorly understood. Methods and Findings. We prospectively studied the epidemiology of GAS infections among children in outpatient hospital clinics in Brussels (Belgium) and Brası´lia (Brazil). Clinical questionnaires were filled out and microbiological sampling was performed. GAS isolates were emm-typed according to the Center for Disease Control protocol. emm pattern was predicted for each isolate. 334 GAS isolates were recovered from 706 children. Skin infections were frequent in Brası´lia (48% of the GAS infections), whereas pharyngitis were predominant (88%) in Brussels. The mean age of children with GAS pharyngitis in Brussels was lower than in Brası´lia (65/92 months, p,0.001). emm-typing revealed striking differences between Brazilian and Belgian GAS isolates. While 20 distinct emm-types were identified among 200 Belgian isolates, 48 were found among 128 Brazilian isolates. Belgian isolates belong mainly to emm pattern A–C (55%) and E (42.5%) while emm pattern E (51.5%) and D (36%) were predominant in Brası´lia. In Brası´lia, emm pattern D isolates were recovered from 18.5% of the pharyngitis, although this emm pattern is supposed to have a skin tropism. By contrast, A–C pattern isolates were unfrequently recovered in a region where rheumatic fever is still highly prevalent. Conclusions. Epidemiologic features of GAS from a pediatric population were very different in an industrialised country and a low incomes region, not only in term of clinical presentation, but also in terms of genetic diversity and distribution of emm patterns. These differences should be taken into account for designing treatment guidelines and vaccine strategies.Faculdade de Medicina (FM)engreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNBORIGINALARTIGO_DifferencesBelgianBrazilian.PDFARTIGO_DifferencesBelgianBrazilian.PDFapplication/pdf185266http://repositorio.unb.br/bitstream/10482/23566/1/ARTIGO_DifferencesBelgianBrazilian.PDF8ad5c02e4578716069cdfa94bc3e5afaMD51open accessLICENSElicense.txtlicense.txttext/plain160http://repositorio.unb.br/bitstream/10482/23566/2/license.txtcd7f2de909e07c008880b5201378c22eMD52open access10482/235662025-01-15 16:06:59.322open accessoai:repositorio.unb.br:10482/23566U3VibWlzcz9vIGVmZXRpdmFkYSBwb3IgaW50ZWdyYW50ZSBkYSBlcXVpcGUgZG8gUmVwb3NpdD9yaW8gSW5zdGl0dWNpb25hbCBkYSBVbkIgZGUgYWNvcmRvIGNvbSBsaWNlbj9hIGNvbmNlZGlkYSBwZWxvIGF1dG9yIGUvb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzLg==Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2025-01-15T19:06:59Repositório Institucional da UnB - Universidade de Brasília (UnB) |
| spellingShingle | Differences between Belgian and Brazilian group A Streptococcus epidemiologic landscape Smeesters, Pierre Robert Streptococcus - epidemiologia - Brasil - Bélgica |
| status_str | publishedVersion |
| title | Differences between Belgian and Brazilian group A Streptococcus epidemiologic landscape |
| title_full | Differences between Belgian and Brazilian group A Streptococcus epidemiologic landscape |
| title_fullStr | Differences between Belgian and Brazilian group A Streptococcus epidemiologic landscape |
| title_full_unstemmed | Differences between Belgian and Brazilian group A Streptococcus epidemiologic landscape |
| title_short | Differences between Belgian and Brazilian group A Streptococcus epidemiologic landscape |
| title_sort | Differences between Belgian and Brazilian group A Streptococcus epidemiologic landscape |
| topic | Streptococcus - epidemiologia - Brasil - Bélgica |
| url | http://repositorio.unb.br/handle/10482/23566 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000010 |