ACE2/ADAM17/TMPRSS2 interplay may be the main risk factor for COVID-19
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| Tác giả chính: | |
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| Ngày xuất bản: | 2020 |
| Tác giả khác: | , , |
| Định dạng: | Article |
| Ngôn ngữ: | eng |
| Nguồn: | Repositório Institucional da UnB |
| Download full: | https://repositorio.unb.br/handle/10482/39636 https://doi.org/10.3389/fimmu.2020.576745 |
Tóm tắt: | The Coronavirus Disease 2019 (COVID-19) has already caused hundreds of thousands of deaths worldwide in a few months. Cardiovascular disease, hypertension, diabetes and chronic lung disease have been identified as the main COVID-19 comorbidities. Moreover, despite similar infection rates between men and women, the most severe course of the disease is higher in elderly and co-morbid male patients. Therefore, the occurrence of specific comorbidities associated with renin–angiotensin system (RAS) imbalance mediated by the interaction between angiotensin-converting enzyme 2 (ACE2) and desintegrin and metalloproteinase domain 17 (ADAM17), along with specific genetic factors mainly associated with type II transmembrane serine protease (TMPRSS2) expression, could be decisive for the clinical outcome of COVID-19. Indeed, the exacerbated ADAM17—mediated ACE2, TNF-α, and IL-6R secretion emerges as a possible underlying mechanism for the acute inflammatory immune response and the activation of the coagulation cascade. Therefore, in this review, we focus on the main pathophysiological aspects of ACE2, ADAM17, and TMPRSS2 host proteins in COVID-19. Additionally, we discuss a possible mechanism to explain the deleterious effect of ADAM17 and TMPRSS2 over-activation in the COVID-19 outcome. |
| _version_ | 1871442380836569088 |
|---|---|
| author | Zipeto, Donato |
| author2 | Palmeira, Julys da Fonseca Argañaraz, Gustavo Adolfo Argañaraz, Enrique Roberto |
| author2_role | author author author |
| author_browse | Argañaraz, Enrique Roberto Argañaraz, Gustavo Adolfo Palmeira, Julys da Fonseca Zipeto, Donato |
| author_facet | Zipeto, Donato Palmeira, Julys da Fonseca Argañaraz, Gustavo Adolfo Argañaraz, Enrique Roberto |
| author_role | author |
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| bitstream.checksumAlgorithm.fl_str_mv | MD5 MD5 |
| bitstream.url.fl_str_mv | http://repositorio2.unb.br/jspui/bitstream/10482/39636/1/ARTIGO_ACE2ADAM17TMPRSS2Interplay.pdf http://repositorio2.unb.br/jspui/bitstream/10482/39636/2/license.txt |
| collection | Repositório Institucional da UnB |
| dc.contributor.author.fl_str_mv | Zipeto, Donato Palmeira, Julys da Fonseca Argañaraz, Gustavo Adolfo Argañaraz, Enrique Roberto |
| dc.date.accessioned.fl_str_mv | 2020-11-16T20:09:53Z |
| dc.date.available.fl_str_mv | 2020-11-16T20:09:53Z |
| dc.date.issued.fl_str_mv | 2020-10-07 |
| dc.identifier.citation.fl_str_mv | ZIPETO, Donato et al. ACE2/ADAM17/TMPRSS2 interplay may be the main risk factor for COVID-19. Frontiers in Immunology, v. 11, art. 576745, out. 2020. DOI: https://doi.org/10.3389/fimmu.2020.576745. Disponível em: https://www.frontiersin.org/articles/10.3389/fimmu.2020.576745/full. Acesso em: 16 nov. 2020. |
| dc.identifier.doi.pt_BR.fl_str_mv | https://doi.org/10.3389/fimmu.2020.576745 |
| dc.identifier.uri.fl_str_mv | https://repositorio.unb.br/handle/10482/39636 |
| dc.language.iso.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Frontiers |
| dc.rights.driver.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
| dc.subject.keyword.pt_BR.fl_str_mv | ADAM17 ACE2 TMPRSS2 SARS-CoV-2 Covid-19 |
| dc.title.pt_BR.fl_str_mv | ACE2/ADAM17/TMPRSS2 interplay may be the main risk factor for COVID-19 |
| dc.type.driver.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | The Coronavirus Disease 2019 (COVID-19) has already caused hundreds of thousands of deaths worldwide in a few months. Cardiovascular disease, hypertension, diabetes and chronic lung disease have been identified as the main COVID-19 comorbidities. Moreover, despite similar infection rates between men and women, the most severe course of the disease is higher in elderly and co-morbid male patients. Therefore, the occurrence of specific comorbidities associated with renin–angiotensin system (RAS) imbalance mediated by the interaction between angiotensin-converting enzyme 2 (ACE2) and desintegrin and metalloproteinase domain 17 (ADAM17), along with specific genetic factors mainly associated with type II transmembrane serine protease (TMPRSS2) expression, could be decisive for the clinical outcome of COVID-19. Indeed, the exacerbated ADAM17—mediated ACE2, TNF-α, and IL-6R secretion emerges as a possible underlying mechanism for the acute inflammatory immune response and the activation of the coagulation cascade. Therefore, in this review, we focus on the main pathophysiological aspects of ACE2, ADAM17, and TMPRSS2 host proteins in COVID-19. Additionally, we discuss a possible mechanism to explain the deleterious effect of ADAM17 and TMPRSS2 over-activation in the COVID-19 outcome. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | UNB_801837840f00a4c1beb1fb95fda7c8b5 |
| identifier_str_mv | ZIPETO, Donato et al. ACE2/ADAM17/TMPRSS2 interplay may be the main risk factor for COVID-19. Frontiers in Immunology, v. 11, art. 576745, out. 2020. DOI: https://doi.org/10.3389/fimmu.2020.576745. Disponível em: https://www.frontiersin.org/articles/10.3389/fimmu.2020.576745/full. Acesso em: 16 nov. 2020. |
| instacron_str | UNB |
| institution | UNB |
| instname_str | Universidade de Brasília (UnB) |
| language | eng |
| network_acronym_str | UNB |
| network_name_str | Repositório Institucional da UnB |
| oai_identifier_str | oai:repositorio.unb.br:10482/39636 |
| publishDate | 2020 |
| publishDateSort | 2020 |
| publisher.none.fl_str_mv | Frontiers |
| reponame_str | Repositório Institucional da UnB |
| repository.mail.fl_str_mv | repositorio@unb.br |
| repository.name.fl_str_mv | Repositório Institucional da UnB - Universidade de Brasília (UnB) |
| repository_id_str | |
| spelling | Zipeto, DonatoPalmeira, Julys da FonsecaArgañaraz, Gustavo AdolfoArgañaraz, Enrique Roberto2020-11-16T20:09:53Z2020-11-16T20:09:53Z2020-10-07ZIPETO, Donato et al. ACE2/ADAM17/TMPRSS2 interplay may be the main risk factor for COVID-19. Frontiers in Immunology, v. 11, art. 576745, out. 2020. DOI: https://doi.org/10.3389/fimmu.2020.576745. Disponível em: https://www.frontiersin.org/articles/10.3389/fimmu.2020.576745/full. Acesso em: 16 nov. 2020.https://repositorio.unb.br/handle/10482/39636https://doi.org/10.3389/fimmu.2020.576745FrontiersCopyright © 2020 Zipeto, Palmeira, Argañaraz and Argañaraz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.info:eu-repo/semantics/openAccessACE2/ADAM17/TMPRSS2 interplay may be the main risk factor for COVID-19info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleADAM17ACE2TMPRSS2SARS-CoV-2Covid-19The Coronavirus Disease 2019 (COVID-19) has already caused hundreds of thousands of deaths worldwide in a few months. Cardiovascular disease, hypertension, diabetes and chronic lung disease have been identified as the main COVID-19 comorbidities. Moreover, despite similar infection rates between men and women, the most severe course of the disease is higher in elderly and co-morbid male patients. Therefore, the occurrence of specific comorbidities associated with renin–angiotensin system (RAS) imbalance mediated by the interaction between angiotensin-converting enzyme 2 (ACE2) and desintegrin and metalloproteinase domain 17 (ADAM17), along with specific genetic factors mainly associated with type II transmembrane serine protease (TMPRSS2) expression, could be decisive for the clinical outcome of COVID-19. Indeed, the exacerbated ADAM17—mediated ACE2, TNF-α, and IL-6R secretion emerges as a possible underlying mechanism for the acute inflammatory immune response and the activation of the coagulation cascade. Therefore, in this review, we focus on the main pathophysiological aspects of ACE2, ADAM17, and TMPRSS2 host proteins in COVID-19. Additionally, we discuss a possible mechanism to explain the deleterious effect of ADAM17 and TMPRSS2 over-activation in the COVID-19 outcome.engreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNBORIGINALARTIGO_ACE2ADAM17TMPRSS2Interplay.pdfARTIGO_ACE2ADAM17TMPRSS2Interplay.pdfapplication/pdf766389http://repositorio2.unb.br/jspui/bitstream/10482/39636/1/ARTIGO_ACE2ADAM17TMPRSS2Interplay.pdf7da6b803334a77476620914b0d321201MD51open accessLICENSElicense.txtlicense.txttext/plain163http://repositorio2.unb.br/jspui/bitstream/10482/39636/2/license.txtba54f8d1c5f5ec8df897ad678916c701MD52open access10482/396362023-05-23 21:10:22.148open accessoai:repositorio.unb.br:10482/39636U3VibWlzc8OjbyBlZmV0aXZhZGEgcG9yIGludGVncmFudGUgZGEgZXF1aXBlIGRvIFJlcG9zaXTDs3JpbyBJbnN0aXR1Y2lvbmFsIGRhIFVuQiBkZSBhY29yZG8gY29tIGxpY2Vuw6dhIGNvbmNlZGlkYSBwZWxvIGF1dG9yIGUvb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzLg==Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2023-05-24T00:10:22Repositório Institucional da UnB - Universidade de Brasília (UnB) |
| spellingShingle | ACE2/ADAM17/TMPRSS2 interplay may be the main risk factor for COVID-19 Zipeto, Donato ADAM17 ACE2 TMPRSS2 SARS-CoV-2 Covid-19 |
| status_str | publishedVersion |
| title | ACE2/ADAM17/TMPRSS2 interplay may be the main risk factor for COVID-19 |
| title_full | ACE2/ADAM17/TMPRSS2 interplay may be the main risk factor for COVID-19 |
| title_fullStr | ACE2/ADAM17/TMPRSS2 interplay may be the main risk factor for COVID-19 |
| title_full_unstemmed | ACE2/ADAM17/TMPRSS2 interplay may be the main risk factor for COVID-19 |
| title_short | ACE2/ADAM17/TMPRSS2 interplay may be the main risk factor for COVID-19 |
| title_sort | ACE2/ADAM17/TMPRSS2 interplay may be the main risk factor for COVID-19 |
| topic | ADAM17 ACE2 TMPRSS2 SARS-CoV-2 Covid-19 |
| url | https://repositorio.unb.br/handle/10482/39636 https://doi.org/10.3389/fimmu.2020.576745 |