Accuracy of mucocutaneous leishmaniasis diagnosis using polymerase chain reaction : systematic literature review and meta-analysis
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| Data de publicació: | 2015 |
| Altres autors: | , , , , , , , , , , |
| Format: | Article |
| Idioma: | eng |
| Font: | Repositório Institucional da UnB |
| Download full: | http://repositorio.unb.br/handle/10482/29536 http://dx.doi.org/10.1590/0074-02760140280 |
Sumari: | The diagnosis of mucocutaneous leishmaniasis (MCL) is hampered by the absence of a gold standard. An accurate diagnosis is essential because of the high toxicity of the medications for the disease. This study aimed to assess the ability of polymerase chain reaction (PCR) to identify MCL and to compare these results with clinical research recently published by the authors. A systematic literature review based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA Statement was performed using comprehensive search criteria and communication with the authors. A meta-analysis considering the estimates of the univariate and bivariate models was performed. Specificity near 100% was common among the papers. The primary reason for accuracy differences was sensitivity. The meta-analysis, which was only possible for PCR samples of lesion fragments, revealed a sensitivity of 71% [95% confidence interval (CI) = 0.59; 0.81] and a specificity of 93% (95% CI = 0.83; 0.98) in the bivariate model. The search for measures that could increase the sensitivity of PCR should be encouraged. The quality of the collected material and the optimisation of the amplification of genetic material should be prioritised. |
| _version_ | 1871442348653674496 |
|---|---|
| author | Gomes, Ciro Martins |
| author2 | Mazin, Suleimy Cristina Santos, Elisa Raphael dos Cesetti, Mariana Vicente Bächtold, Guilherme Albergaria Brízida Cordeiro, João Henrique de Freitas Theodoro, Fabrício Claudino Estrela Terra Damasco, Fabiana dos Santos Carranza, Sebastián Andrés Vernal Santos, Adriana de Oliveira Roselino, Ana Maria Sampaio, Raimunda Nonata Ribeiro |
| author2_role | author author author author author author author author author author author |
| author_browse | Bächtold, Guilherme Albergaria Brízida Carranza, Sebastián Andrés Vernal Cesetti, Mariana Vicente Cordeiro, João Henrique de Freitas Damasco, Fabiana dos Santos Gomes, Ciro Martins Mazin, Suleimy Cristina Roselino, Ana Maria Sampaio, Raimunda Nonata Ribeiro Santos, Adriana de Oliveira Santos, Elisa Raphael dos Theodoro, Fabrício Claudino Estrela Terra |
| author_facet | Gomes, Ciro Martins Mazin, Suleimy Cristina Santos, Elisa Raphael dos Cesetti, Mariana Vicente Bächtold, Guilherme Albergaria Brízida Cordeiro, João Henrique de Freitas Theodoro, Fabrício Claudino Estrela Terra Damasco, Fabiana dos Santos Carranza, Sebastián Andrés Vernal Santos, Adriana de Oliveira Roselino, Ana Maria Sampaio, Raimunda Nonata Ribeiro |
| author_role | author |
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| bitstream.url.fl_str_mv | http://repositorio.unb.br/bitstream/10482/29536/1/ARTIGO_AccuracyMucocutaneousLeishmaniasis.pdf |
| collection | Repositório Institucional da UnB |
| dc.contributor.author.fl_str_mv | Gomes, Ciro Martins Mazin, Suleimy Cristina Santos, Elisa Raphael dos Cesetti, Mariana Vicente Bächtold, Guilherme Albergaria Brízida Cordeiro, João Henrique de Freitas Theodoro, Fabrício Claudino Estrela Terra Damasco, Fabiana dos Santos Carranza, Sebastián Andrés Vernal Santos, Adriana de Oliveira Roselino, Ana Maria Sampaio, Raimunda Nonata Ribeiro |
| dc.date.accessioned.fl_str_mv | 2017-12-07T05:11:37Z |
| dc.date.available.fl_str_mv | 2017-12-07T05:11:37Z |
| dc.date.issued.fl_str_mv | 2015-04 |
| dc.identifier.citation.fl_str_mv | GOMES, Ciro Martins et al. Accuracy of mucocutaneous leishmaniasis diagnosis using polymerase chain reaction: systematic literature review and meta-analysis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 110, n. 2, p. 157-165, abr. 2015. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000200157&lng=en&nrm=iso>. Acesso em: 9 maio 2018. Epub Mar 31, 2015. doi: http://dx.doi.org/10.1590/0074-02760140280. |
| dc.identifier.doi.pt_BR.fl_str_mv | http://dx.doi.org/10.1590/0074-02760140280 |
| dc.identifier.uri.fl_str_mv | http://repositorio.unb.br/handle/10482/29536 |
| dc.language.iso.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Instituto Oswaldo Cruz, Ministério da Saúde |
| dc.rights.driver.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
| dc.subject.keyword.pt_BR.fl_str_mv | Leishmaniose Diagnóstico |
| dc.title.pt_BR.fl_str_mv | Accuracy of mucocutaneous leishmaniasis diagnosis using polymerase chain reaction : systematic literature review and meta-analysis |
| dc.type.driver.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | The diagnosis of mucocutaneous leishmaniasis (MCL) is hampered by the absence of a gold standard. An accurate diagnosis is essential because of the high toxicity of the medications for the disease. This study aimed to assess the ability of polymerase chain reaction (PCR) to identify MCL and to compare these results with clinical research recently published by the authors. A systematic literature review based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA Statement was performed using comprehensive search criteria and communication with the authors. A meta-analysis considering the estimates of the univariate and bivariate models was performed. Specificity near 100% was common among the papers. The primary reason for accuracy differences was sensitivity. The meta-analysis, which was only possible for PCR samples of lesion fragments, revealed a sensitivity of 71% [95% confidence interval (CI) = 0.59; 0.81] and a specificity of 93% (95% CI = 0.83; 0.98) in the bivariate model. The search for measures that could increase the sensitivity of PCR should be encouraged. The quality of the collected material and the optimisation of the amplification of genetic material should be prioritised. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | UNB_6c2a1d8ea3bd4a3dd9e1bc1c8c98489f |
| identifier_str_mv | GOMES, Ciro Martins et al. Accuracy of mucocutaneous leishmaniasis diagnosis using polymerase chain reaction: systematic literature review and meta-analysis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 110, n. 2, p. 157-165, abr. 2015. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000200157&lng=en&nrm=iso>. Acesso em: 9 maio 2018. Epub Mar 31, 2015. doi: http://dx.doi.org/10.1590/0074-02760140280. |
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| instname_str | Universidade de Brasília (UnB) |
| language | eng |
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| network_name_str | Repositório Institucional da UnB |
| oai_identifier_str | oai:repositorio.unb.br:10482/29536 |
| publishDate | 2015 |
| publishDateSort | 2015 |
| publisher.none.fl_str_mv | Instituto Oswaldo Cruz, Ministério da Saúde |
| reponame_str | Repositório Institucional da UnB |
| repository.mail.fl_str_mv | repositorio@unb.br |
| repository.name.fl_str_mv | Repositório Institucional da UnB - Universidade de Brasília (UnB) |
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| spelling | Gomes, Ciro MartinsMazin, Suleimy CristinaSantos, Elisa Raphael dosCesetti, Mariana VicenteBächtold, Guilherme Albergaria BrízidaCordeiro, João Henrique de FreitasTheodoro, Fabrício Claudino Estrela TerraDamasco, Fabiana dos SantosCarranza, Sebastián Andrés VernalSantos, Adriana de OliveiraRoselino, Ana MariaSampaio, Raimunda Nonata Ribeiro2017-12-07T05:11:37Z2017-12-07T05:11:37Z2015-04GOMES, Ciro Martins et al. Accuracy of mucocutaneous leishmaniasis diagnosis using polymerase chain reaction: systematic literature review and meta-analysis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 110, n. 2, p. 157-165, abr. 2015. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000200157&lng=en&nrm=iso>. Acesso em: 9 maio 2018. Epub Mar 31, 2015. doi: http://dx.doi.org/10.1590/0074-02760140280.http://repositorio.unb.br/handle/10482/29536http://dx.doi.org/10.1590/0074-02760140280Instituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License (CC BY NC 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000200157&lng=en&nrm=iso. Acesso em: 9 maio 2018.info:eu-repo/semantics/openAccessAccuracy of mucocutaneous leishmaniasis diagnosis using polymerase chain reaction : systematic literature review and meta-analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLeishmanioseDiagnósticoThe diagnosis of mucocutaneous leishmaniasis (MCL) is hampered by the absence of a gold standard. An accurate diagnosis is essential because of the high toxicity of the medications for the disease. This study aimed to assess the ability of polymerase chain reaction (PCR) to identify MCL and to compare these results with clinical research recently published by the authors. A systematic literature review based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA Statement was performed using comprehensive search criteria and communication with the authors. A meta-analysis considering the estimates of the univariate and bivariate models was performed. Specificity near 100% was common among the papers. The primary reason for accuracy differences was sensitivity. The meta-analysis, which was only possible for PCR samples of lesion fragments, revealed a sensitivity of 71% [95% confidence interval (CI) = 0.59; 0.81] and a specificity of 93% (95% CI = 0.83; 0.98) in the bivariate model. The search for measures that could increase the sensitivity of PCR should be encouraged. The quality of the collected material and the optimisation of the amplification of genetic material should be prioritised.Faculdade de Medicina (FM)engreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNBORIGINALARTIGO_AccuracyMucocutaneousLeishmaniasis.pdfARTIGO_AccuracyMucocutaneousLeishmaniasis.pdfapplication/pdf943427http://repositorio.unb.br/bitstream/10482/29536/1/ARTIGO_AccuracyMucocutaneousLeishmaniasis.pdfd3648350db2029cfe739fea2299f84a6MD51open access10482/295362024-09-19 12:17:41.607open accessoai:repositorio.unb.br:10482/29536Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2024-09-19T15:17:41Repositório Institucional da UnB - Universidade de Brasília (UnB) |
| spellingShingle | Accuracy of mucocutaneous leishmaniasis diagnosis using polymerase chain reaction : systematic literature review and meta-analysis Gomes, Ciro Martins Leishmaniose Diagnóstico |
| status_str | publishedVersion |
| title | Accuracy of mucocutaneous leishmaniasis diagnosis using polymerase chain reaction : systematic literature review and meta-analysis |
| title_full | Accuracy of mucocutaneous leishmaniasis diagnosis using polymerase chain reaction : systematic literature review and meta-analysis |
| title_fullStr | Accuracy of mucocutaneous leishmaniasis diagnosis using polymerase chain reaction : systematic literature review and meta-analysis |
| title_full_unstemmed | Accuracy of mucocutaneous leishmaniasis diagnosis using polymerase chain reaction : systematic literature review and meta-analysis |
| title_short | Accuracy of mucocutaneous leishmaniasis diagnosis using polymerase chain reaction : systematic literature review and meta-analysis |
| title_sort | Accuracy of mucocutaneous leishmaniasis diagnosis using polymerase chain reaction : systematic literature review and meta-analysis |
| topic | Leishmaniose Diagnóstico |
| url | http://repositorio.unb.br/handle/10482/29536 http://dx.doi.org/10.1590/0074-02760140280 |