Polimorfismo TP53 Arg72Pro e sua relação com o transtorno depressivo maior
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| Autore principale: | |
|---|---|
| Data di pubblicazione: | 2026 |
| Altri autori: | , , , , |
| Natura: | Article |
| Lingua: | por |
| Fonte: | Repositório Institucional da UnB |
| Download full: | http://repositorio.unb.br/handle/10482/55258 https://doi.org/10.53660/CLM-3726-23P17 https://orcid.org/0009-0009-5216-1045 https://orcid.org/0000-0002-7812-8026 https://orcid.org/0000-0002-3716-7221 https://orcid.org/0000-0002-9064-0735 https://orcid.org/0000-0002-0511-9452 https://orcid.org/0000-0002-6836-3583 |
Riassunto: | This study investigates the association between theTP53 Arg72Propolymorphism and major depressive disorder (MDD) using a case-control approach. The study sample comprised 97 individuals: 16 in the case group diagnosed with MDD and 81 in the control group. Genotypingwas conducted using the PCR-RFLP technique, with the genotypic frequencies calculated by direct counting and statistical significance at 5% (P<0.05). Results indicated that theTP53 Arg72Propolymorphism'sProallele was significantly more frequent in the MDD case group. These findings suggest that the Proallele is associated with an increased risk of developing major depressive disorder. |
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