Behavioral and electroencephalographic analysis of seizures induced by intrahippocampal injection of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granulifera
Saved in:
| Main Author: | |
|---|---|
| Publication Date: | 2001 |
| Other Authors: | , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositório Institucional da UnB |
| Download full: | http://repositorio.unb.br/handle/10482/25734 https://dx.doi.org/10.1590/S0100-879X2001000600016 |
Summary: | In this study, the behavioral and electroencephalographic (EEG) analysis of seizures induced by the intrahippocampal injection in rats of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granulifera, was determined. The first alterations occurred during microinjection of granulitoxin (8 µg) into the dorsal hippocampus and consisted of seizure activity that began in the hippocampus and spread rapidly to the occipital cortex. This activity lasted 20-30 s, and during this period the rats presented immobility. During the first 40-50 min after its administration, three to four other similar short EEG seizure periods occurred and the rats presented the following behavioral alterations: akinesia, facial automatisms, head tremor, salivation, rearing, jumping, barrel-rolling, wet dog shakes and forelimb clonic movements. Within 40-50 min, the status epilepticus was established and lasted 8-12 h. These results are similar to those observed in the acute phase of the pilocarpine model of temporal lobe epilepsy and suggest that granulitoxin may be a useful tool not only to study the sodium channels, but also to develop a new experimental model of status epilepticus. |
| _version_ | 1871442307062956032 |
|---|---|
| author | Santana, A.N.C. |
| author2 | Trindade-Filho, E.M. Cunha, R.B. Sousa, M.V. Cavalheiro, E.A. Carvalho, K.M. |
| author2_role | author author author author author |
| author_browse | Carvalho, K.M. Cavalheiro, E.A. Cunha, R.B. Santana, A.N.C. Sousa, M.V. Trindade-Filho, E.M. |
| author_facet | Santana, A.N.C. Trindade-Filho, E.M. Cunha, R.B. Sousa, M.V. Cavalheiro, E.A. Carvalho, K.M. |
| author_role | author |
| bitstream.checksum.fl_str_mv | 6fe5fc6e766dff37c65a2a1ed1232467 |
| bitstream.checksumAlgorithm.fl_str_mv | MD5 |
| bitstream.url.fl_str_mv | http://repositorio.unb.br/bitstream/10482/25734/1/3880m.pdf |
| collection | Repositório Institucional da UnB |
| dc.contributor.author.fl_str_mv | Santana, A.N.C. Trindade-Filho, E.M. Cunha, R.B. Sousa, M.V. Cavalheiro, E.A. Carvalho, K.M. |
| dc.date.accessioned.fl_str_mv | 2017-12-07T04:33:56Z |
| dc.date.available.fl_str_mv | 2017-12-07T04:33:56Z |
| dc.date.issued.fl_str_mv | 2001 |
| dc.identifier.citation.fl_str_mv | Braz J Med Biol Res,v.34,n.6,p.797-801,2001 |
| dc.identifier.doi.pt_BR.fl_str_mv | https://dx.doi.org/10.1590/S0100-879X2001000600016 |
| dc.identifier.uri.fl_str_mv | http://repositorio.unb.br/handle/10482/25734 |
| dc.language.iso.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Associação Brasileira de Divulgação Científica |
| dc.rights.driver.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
| dc.subject.keyword.pt_BR.fl_str_mv | Bunodosoma Granulifera Granulitoxina Anêmonas do mar Peptídeos tóxicos Convulsão Ensaio eletroencefalográfico |
| dc.title.pt_BR.fl_str_mv | Behavioral and electroencephalographic analysis of seizures induced by intrahippocampal injection of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granulifera |
| dc.type.driver.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | In this study, the behavioral and electroencephalographic (EEG) analysis of seizures induced by the intrahippocampal injection in rats of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granulifera, was determined. The first alterations occurred during microinjection of granulitoxin (8 µg) into the dorsal hippocampus and consisted of seizure activity that began in the hippocampus and spread rapidly to the occipital cortex. This activity lasted 20-30 s, and during this period the rats presented immobility. During the first 40-50 min after its administration, three to four other similar short EEG seizure periods occurred and the rats presented the following behavioral alterations: akinesia, facial automatisms, head tremor, salivation, rearing, jumping, barrel-rolling, wet dog shakes and forelimb clonic movements. Within 40-50 min, the status epilepticus was established and lasted 8-12 h. These results are similar to those observed in the acute phase of the pilocarpine model of temporal lobe epilepsy and suggest that granulitoxin may be a useful tool not only to study the sodium channels, but also to develop a new experimental model of status epilepticus. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | UNB_4e4b7d4f31bdd57dbea3c4bd77d3c6ae |
| identifier_str_mv | Braz J Med Biol Res,v.34,n.6,p.797-801,2001 |
| instacron_str | UNB |
| institution | UNB |
| instname_str | Universidade de Brasília (UnB) |
| language | eng |
| network_acronym_str | UNB |
| network_name_str | Repositório Institucional da UnB |
| oai_identifier_str | oai:repositorio.unb.br:10482/25734 |
| publishDate | 2001 |
| publishDateSort | 2001 |
| publisher.none.fl_str_mv | Associação Brasileira de Divulgação Científica |
| reponame_str | Repositório Institucional da UnB |
| repository.mail.fl_str_mv | repositorio@unb.br |
| repository.name.fl_str_mv | Repositório Institucional da UnB - Universidade de Brasília (UnB) |
| repository_id_str | |
| spelling | Santana, A.N.C.Trindade-Filho, E.M.Cunha, R.B.Sousa, M.V.Cavalheiro, E.A.Carvalho, K.M.2017-12-07T04:33:56Z2017-12-07T04:33:56Z2001Braz J Med Biol Res,v.34,n.6,p.797-801,2001http://repositorio.unb.br/handle/10482/25734https://dx.doi.org/10.1590/S0100-879X2001000600016In this study, the behavioral and electroencephalographic (EEG) analysis of seizures induced by the intrahippocampal injection in rats of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granulifera, was determined. The first alterations occurred during microinjection of granulitoxin (8 µg) into the dorsal hippocampus and consisted of seizure activity that began in the hippocampus and spread rapidly to the occipital cortex. This activity lasted 20-30 s, and during this period the rats presented immobility. During the first 40-50 min after its administration, three to four other similar short EEG seizure periods occurred and the rats presented the following behavioral alterations: akinesia, facial automatisms, head tremor, salivation, rearing, jumping, barrel-rolling, wet dog shakes and forelimb clonic movements. Within 40-50 min, the status epilepticus was established and lasted 8-12 h. These results are similar to those observed in the acute phase of the pilocarpine model of temporal lobe epilepsy and suggest that granulitoxin may be a useful tool not only to study the sodium channels, but also to develop a new experimental model of status epilepticus.Em processamentoAssociação Brasileira de Divulgação CientíficaBehavioral and electroencephalographic analysis of seizures induced by intrahippocampal injection of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granuliferainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBunodosoma GranuliferaGranulitoxinaAnêmonas do marPeptídeos tóxicosConvulsãoEnsaio eletroencefalográficoinfo:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNBORIGINAL3880m.pdfapplication/pdf142176http://repositorio.unb.br/bitstream/10482/25734/1/3880m.pdf6fe5fc6e766dff37c65a2a1ed1232467MD51open access10482/257342024-08-28 16:04:07.464open accessoai:repositorio.unb.br:10482/25734Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2024-08-28T19:04:07Repositório Institucional da UnB - Universidade de Brasília (UnB) |
| spellingShingle | Behavioral and electroencephalographic analysis of seizures induced by intrahippocampal injection of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granulifera Santana, A.N.C. Bunodosoma Granulifera Granulitoxina Anêmonas do mar Peptídeos tóxicos Convulsão Ensaio eletroencefalográfico |
| status_str | publishedVersion |
| title | Behavioral and electroencephalographic analysis of seizures induced by intrahippocampal injection of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granulifera |
| title_full | Behavioral and electroencephalographic analysis of seizures induced by intrahippocampal injection of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granulifera |
| title_fullStr | Behavioral and electroencephalographic analysis of seizures induced by intrahippocampal injection of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granulifera |
| title_full_unstemmed | Behavioral and electroencephalographic analysis of seizures induced by intrahippocampal injection of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granulifera |
| title_short | Behavioral and electroencephalographic analysis of seizures induced by intrahippocampal injection of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granulifera |
| title_sort | Behavioral and electroencephalographic analysis of seizures induced by intrahippocampal injection of granulitoxin, a neurotoxic peptide from the sea anemone Bunodosoma granulifera |
| topic | Bunodosoma Granulifera Granulitoxina Anêmonas do mar Peptídeos tóxicos Convulsão Ensaio eletroencefalográfico |
| url | http://repositorio.unb.br/handle/10482/25734 https://dx.doi.org/10.1590/S0100-879X2001000600016 |